Osteopontin expression in particle-induced lung disease.

Journal Article (Journal Article)

Osteopontin (OPN) is a secreted cytokine with cell adhesive and chemoattractive functions whose expression is induced by a variety of environmental toxicants. It has been implicated in the pathogenesis of several pulmonary granulomatous and fibrotic conditions. For these reasons the authors investigated OPN expression in experimental particle-induced lung disease using a titanium dioxide exposure model in the rat. Under exposure conditions that resulted in fibroproliferative lung disease, rats had significant increases in total lung OPN mRNA expression and increased levels of OPN protein in bronchoalveolar lavage fluid (BALF) prior to the development of lesions. OPN immunoreactivity studies of lesion development provide evidence that this multifunctional cytokine may be important in the pathogenesis of particle-induced lung disease. Findings suggest that OPN may serve as an important biomarker for particle-induced lung disease.

Full Text

Duke Authors

Cited Authors

  • Mangum, J; Bermudez, E; Sar, M; Everitt, J

Published Date

  • October 2004

Published In

Volume / Issue

  • 30 / 7

Start / End Page

  • 585 - 598

PubMed ID

  • 15371094

International Standard Serial Number (ISSN)

  • 0190-2148

Digital Object Identifier (DOI)

  • 10.1080/01902140490476346


  • eng

Conference Location

  • England