The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats.

Journal Article

Chronic progressive nephropathy (CPN) is the most frequently diagnosed lesion in the rat kidney. It has many components including degeneration and regeneration of renal tubule (RT) epithelium, glomerular lesions and interstitial inflammation and fibrosis. The incidence and severity of CPN is strain, age, and sex dependent and may be altered by a number of factors including exposure to xenobiotics. In National Toxicology Program (NTP) 2-year bioassays, xenobiotic-associated increased severity (exacerbation) of CPN often occurs in association with a marginal increased incidence of renal tubule cell neoplasms (RTCN). The relationship between CPN and RTCN development has not been definitively determined. The present study evaluated the association between severity of CPN and the occurrence of RTCN in control male F344 rats. A slight but statistically significant increase in CPN severity was present in those animals with RTCN compared to aged-matched controls without RTCN. Although these data suggest there is a positive correlation between CPN and RTCN, cause and effect were not determined. This marginal association suggests that the number of RTCNs that may develop secondary to chemically exacerbated nephropathy would be few.

Full Text

Duke Authors

Cited Authors

  • Seely, JC; Haseman, JK; Nyska, A; Wolf, DC; Everitt, JI; Hailey, JR

Published Date

  • November 2002

Published In

Volume / Issue

  • 30 / 6

Start / End Page

  • 681 - 686

PubMed ID

  • 12512869

Electronic International Standard Serial Number (EISSN)

  • 1533-1601

International Standard Serial Number (ISSN)

  • 0192-6233

Digital Object Identifier (DOI)

  • 10.1080/01926230290166779

Language

  • eng