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Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos.

Publication ,  Journal Article
Hill, GD; Mangum, JB; Moss, OR; Everitt, JI
Published in: Exp Lung Res
July 2003

Pleural inflammation is a sequela of exposure to toxic mineral fibers such as amosite asbestos. This inflammatory response involves the influx of leukocytes from the vasculature into the pleural space. Adhesion molecules such as intercellular adhesion molecule-1 (ICAM)-1 and chemokines such as monocyte chemoattractant protein-1 (MCP)-1 and macrophage inhibitory protein-2 (MIP)-2 are known to be important in pulmonary inflammation following inhalation of particulate matter. However, little is known about their role in pleural inflammation secondary to amosite asbestos exposure. Because the pleural mesothelial cell is believed to be a key target cell of asbestos exposure, the purpose of this study was to determine if ICAM-1, MCP-1, and MIP-2 proteins were secreted by these mesothelial cells following in vitro and in vivo exposure to amosite asbestos. Increased levels of ICAM-1 and MCP-1 protein were measured following 24 or 48 hours exposure of cultured rat pleural mesothelial cells to amosite fibers (1.5 to 5.0 micro g/cm(2)). Increased levels of ICAM-1, MCP-1, and MIP-2 protein were found in pleural lavage fluid from Fischer-344 rats exposed to amosite asbestos for 4 and 12 weeks and after a 12-week recovery period (following the 12-week exposure period). These findings suggest that the secretion of ICAM-1, MCP-1, and MIP-2 by rat pleural mesothelial cells may contribute to amosite-induced pleural inflammation.

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Published In

Exp Lung Res

DOI

ISSN

0190-2148

Publication Date

July 2003

Volume

29

Issue

5

Start / End Page

277 / 290

Location

England

Related Subject Headings

  • Specific Pathogen-Free Organisms
  • Respiratory System
  • Rats, Inbred F344
  • Rats
  • Pleurisy
  • Pleural Effusion
  • Pleura
  • Monokines
  • Male
  • Intercellular Signaling Peptides and Proteins
 

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Hill, G. D., Mangum, J. B., Moss, O. R., & Everitt, J. I. (2003). Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos. Exp Lung Res, 29(5), 277–290. https://doi.org/10.1080/01902140303788
Hill, Georgette D., James B. Mangum, Owen R. Moss, and Jeffrey I. Everitt. “Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos.Exp Lung Res 29, no. 5 (July 2003): 277–90. https://doi.org/10.1080/01902140303788.
Hill, Georgette D., et al. “Soluble ICAM-1, MCP-1, and MIP-2 protein secretion by rat pleural mesothelial cells following exposure to amosite asbestos.Exp Lung Res, vol. 29, no. 5, July 2003, pp. 277–90. Pubmed, doi:10.1080/01902140303788.
Journal cover image

Published In

Exp Lung Res

DOI

ISSN

0190-2148

Publication Date

July 2003

Volume

29

Issue

5

Start / End Page

277 / 290

Location

England

Related Subject Headings

  • Specific Pathogen-Free Organisms
  • Respiratory System
  • Rats, Inbred F344
  • Rats
  • Pleurisy
  • Pleural Effusion
  • Pleura
  • Monokines
  • Male
  • Intercellular Signaling Peptides and Proteins