Thrombin expression in prostate: a novel finding.
Publication
, Journal Article
Kohli, M; Williams, K; Yao, JL; Dennis, RA; Huang, J; Reeder, J; Ricke, WA
Published in: Cancer Invest
January 2011
INTRODUCTION: A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS: Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays. RESULTS: (Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05). CONCLUSIONS: Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.
Duke Scholars
Published In
Cancer Invest
DOI
EISSN
1532-4192
Publication Date
January 2011
Volume
29
Issue
1
Start / End Page
62 / 67
Location
England
Related Subject Headings
- Tissue Array Analysis
- Thrombin
- Stromal Cells
- RNA, Messenger
- Prothrombin
- Prostatic Neoplasms
- Prostate
- Polymerase Chain Reaction
- Oncology & Carcinogenesis
- Male
Citation
APA
Chicago
ICMJE
MLA
NLM
Kohli, M., Williams, K., Yao, J. L., Dennis, R. A., Huang, J., Reeder, J., & Ricke, W. A. (2011). Thrombin expression in prostate: a novel finding. Cancer Invest, 29(1), 62–67. https://doi.org/10.3109/07357907.2010.535057
Kohli, Manish, Karin Williams, Jorge L. Yao, Richard A. Dennis, Jiaoti Huang, Jay Reeder, and William A. Ricke. “Thrombin expression in prostate: a novel finding.” Cancer Invest 29, no. 1 (January 2011): 62–67. https://doi.org/10.3109/07357907.2010.535057.
Kohli M, Williams K, Yao JL, Dennis RA, Huang J, Reeder J, et al. Thrombin expression in prostate: a novel finding. Cancer Invest. 2011 Jan;29(1):62–7.
Kohli, Manish, et al. “Thrombin expression in prostate: a novel finding.” Cancer Invest, vol. 29, no. 1, Jan. 2011, pp. 62–67. Pubmed, doi:10.3109/07357907.2010.535057.
Kohli M, Williams K, Yao JL, Dennis RA, Huang J, Reeder J, Ricke WA. Thrombin expression in prostate: a novel finding. Cancer Invest. 2011 Jan;29(1):62–67.
Published In
Cancer Invest
DOI
EISSN
1532-4192
Publication Date
January 2011
Volume
29
Issue
1
Start / End Page
62 / 67
Location
England
Related Subject Headings
- Tissue Array Analysis
- Thrombin
- Stromal Cells
- RNA, Messenger
- Prothrombin
- Prostatic Neoplasms
- Prostate
- Polymerase Chain Reaction
- Oncology & Carcinogenesis
- Male