Optical-resolution photoacoustic endomicroscopy in vivo.

Journal Article (Journal Article)

Optical-resolution photoacoustic microscopy (OR-PAM) has become a major experimental tool of photoacoustic tomography, with unique imaging capabilities for various biological applications. However, conventional imaging systems are all table-top embodiments, which preclude their use in internal organs. In this study, by applying the OR-PAM concept to our recently developed endoscopic technique, called photoacoustic endoscopy (PAE), we created an optical-resolution photoacoustic endomicroscopy (OR-PAEM) system, which enables internal organ imaging with a much finer resolution than conventional acoustic-resolution PAE systems. OR-PAEM has potential preclinical and clinical applications using either endogenous or exogenous contrast agents.

Full Text

Duke Authors

Cited Authors

  • Yang, J-M; Li, C; Chen, R; Rao, B; Yao, J; Yeh, C-H; Danielli, A; Maslov, K; Zhou, Q; Shung, KK; Wang, LV

Published Date

  • March 2015

Published In

Volume / Issue

  • 6 / 3

Start / End Page

  • 918 - 932

PubMed ID

  • 25798315

Pubmed Central ID

  • PMC4361445

Electronic International Standard Serial Number (EISSN)

  • 2156-7085

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/boe.6.000918


  • eng