Photoacoustic Brain Imaging: from Microscopic to Macroscopic Scales.


Journal Article

Human brain mapping has become one of the most exciting contemporary research areas, with major breakthroughs expected in the following decades. Modern brain imaging techniques have allowed neuroscientists to gather a wealth of anatomic and functional information about the brain. Among these techniques, by virtue of its rich optical absorption contrast, high spatial and temporal resolutions, and deep penetration, photoacoustic tomography (PAT) has attracted more and more attention, and is playing an increasingly important role in brain studies. In particular, PAT complements other brain imaging modalities by providing high-resolution functional and metabolic imaging. More importantly, PAT's unique scalability enables scrutinizing the brain at both microscopic and macroscopic scales, using the same imaging contrast. In this Review, we present the state-of-the-art PAT techniques for brain imaging, summarize representative neuroscience applications, outline the technical challenges in translating PAT to human brain imaging, and envision potential technological deliverables.

Full Text

Duke Authors

Cited Authors

  • Yao, J; Wang, LV

Published Date

  • May 2014

Published In

Volume / Issue

  • 1 / 1

PubMed ID

  • 25401121

Pubmed Central ID

  • 25401121

Electronic International Standard Serial Number (EISSN)

  • 2329-4248

International Standard Serial Number (ISSN)

  • 2329-423X

Digital Object Identifier (DOI)

  • 10.1117/1.NPh.1.1.011003


  • eng