Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses.

Published online

Journal Article

T follicular helper (Tfh) cells play critical roles for germinal center responses and effective humoral immunity. We report here that mTOR in CD4 T cells is essential for Tfh differentiation. In Mtorf/f-Cd4Cre mice, both constitutive and inducible Tfh differentiation is severely impaired, leading to defective germinal center B cell formation and antibody production. Moreover, both mTORC1 and mTORC2 contribute to Tfh and GC B cell development but may do so via distinct mechanisms. mTORC1 mainly promotes CD4 T cell proliferation to reach the cell divisions necessary for Tfh differentiation, while Rictor/mTORC2 regulates Tfh differentiation by promoting Akt activation and TCF1 expression without grossly influencing T cell proliferation. Together, our results reveal crucial but distinct roles for mTORC1 and mTORC2 in CD4 T cells during Tfh differentiation and germinal center responses.

Full Text

Duke Authors

Cited Authors

  • Yang, J; Lin, X; Pan, Y; Wang, J; Chen, P; Huang, H; Xue, H-H; Gao, J; Zhong, X-P

Published Date

  • September 30, 2016

Published In

Volume / Issue

  • 5 /

PubMed ID

  • 27690224

Pubmed Central ID

  • 27690224

Electronic International Standard Serial Number (EISSN)

  • 2050-084X

Digital Object Identifier (DOI)

  • 10.7554/eLife.17936

Language

  • eng

Conference Location

  • England