Skip to main content

Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.

Publication ,  Journal Article
Materin, MA; Kuzmik, GA; Jubinsky, PT; Minja, FJ; Asnes, JD; Bulsara, KR
Published in: J Neurointerv Surg
November 2013

We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.

Duke Scholars

Published In

J Neurointerv Surg

DOI

EISSN

1759-8486

Publication Date

November 2013

Volume

5

Issue

6

Start / End Page

e42

Location

England

Related Subject Headings

  • Visual Acuity
  • Treatment Outcome
  • Retinoblastoma
  • Retinal Neoplasms
  • Retinal Detachment
  • Retinal Artery
  • Melphalan
  • Male
  • Magnetic Resonance Angiography
  • Intraoperative Period
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Materin, M. A., Kuzmik, G. A., Jubinsky, P. T., Minja, F. J., Asnes, J. D., & Bulsara, K. R. (2013). Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. J Neurointerv Surg, 5(6), e42. https://doi.org/10.1136/neurintsurg-2012-010508.rep
Materin, Miguel A., Gregory A. Kuzmik, Paul T. Jubinsky, Frank J. Minja, Jeremy D. Asnes, and Ketan R. Bulsara. “Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.J Neurointerv Surg 5, no. 6 (November 2013): e42. https://doi.org/10.1136/neurintsurg-2012-010508.rep.
Materin MA, Kuzmik GA, Jubinsky PT, Minja FJ, Asnes JD, Bulsara KR. Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. J Neurointerv Surg. 2013 Nov;5(6):e42.
Materin, Miguel A., et al. “Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.J Neurointerv Surg, vol. 5, no. 6, Nov. 2013, p. e42. Pubmed, doi:10.1136/neurintsurg-2012-010508.rep.
Materin MA, Kuzmik GA, Jubinsky PT, Minja FJ, Asnes JD, Bulsara KR. Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. J Neurointerv Surg. 2013 Nov;5(6):e42.

Published In

J Neurointerv Surg

DOI

EISSN

1759-8486

Publication Date

November 2013

Volume

5

Issue

6

Start / End Page

e42

Location

England

Related Subject Headings

  • Visual Acuity
  • Treatment Outcome
  • Retinoblastoma
  • Retinal Neoplasms
  • Retinal Detachment
  • Retinal Artery
  • Melphalan
  • Male
  • Magnetic Resonance Angiography
  • Intraoperative Period