Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.
We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.
Duke Scholars
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Related Subject Headings
- Visual Acuity
- Treatment Outcome
- Retinoblastoma
- Retinal Neoplasms
- Retinal Detachment
- Retinal Artery
- Melphalan
- Male
- Magnetic Resonance Angiography
- Intraoperative Period
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Visual Acuity
- Treatment Outcome
- Retinoblastoma
- Retinal Neoplasms
- Retinal Detachment
- Retinal Artery
- Melphalan
- Male
- Magnetic Resonance Angiography
- Intraoperative Period