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Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.

Publication ,  Journal Article
Materin, MA; Kuzmik, GA; Jubinsky, PT; Minja, FJ; Asnes, JD; Bulsara, KR
Published in: BMJ Case Rep
November 15, 2012

We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.

Duke Scholars

Published In

BMJ Case Rep

DOI

EISSN

1757-790X

Publication Date

November 15, 2012

Volume

2012

Location

England

Related Subject Headings

  • Retinoblastoma
  • Retinal Neoplasms
  • Ophthalmic Artery
  • Melphalan
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Gadolinium
  • Contrast Media
  • Antineoplastic Agents, Alkylating
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Materin, M. A., Kuzmik, G. A., Jubinsky, P. T., Minja, F. J., Asnes, J. D., & Bulsara, K. R. (2012). Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. BMJ Case Rep, 2012. https://doi.org/10.1136/bcr-2012-010508
Materin, Miguel A., Gregory A. Kuzmik, Paul T. Jubinsky, Frank J. Minja, Jeremy D. Asnes, and Ketan R. Bulsara. “Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.BMJ Case Rep 2012 (November 15, 2012). https://doi.org/10.1136/bcr-2012-010508.
Materin MA, Kuzmik GA, Jubinsky PT, Minja FJ, Asnes JD, Bulsara KR. Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. BMJ Case Rep. 2012 Nov 15;2012.
Materin, Miguel A., et al. “Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.BMJ Case Rep, vol. 2012, Nov. 2012. Pubmed, doi:10.1136/bcr-2012-010508.
Materin MA, Kuzmik GA, Jubinsky PT, Minja FJ, Asnes JD, Bulsara KR. Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. BMJ Case Rep. 2012 Nov 15;2012.

Published In

BMJ Case Rep

DOI

EISSN

1757-790X

Publication Date

November 15, 2012

Volume

2012

Location

England

Related Subject Headings

  • Retinoblastoma
  • Retinal Neoplasms
  • Ophthalmic Artery
  • Melphalan
  • Magnetic Resonance Imaging
  • Infant
  • Humans
  • Gadolinium
  • Contrast Media
  • Antineoplastic Agents, Alkylating