Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium.

Journal Article (Journal Article)

We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.

Full Text

Duke Authors

Cited Authors

  • Materin, MA; Kuzmik, GA; Jubinsky, PT; Minja, FJ; Asnes, JD; Bulsara, KR

Published Date

  • November 15, 2012

Published In

Volume / Issue

  • 2012 /

PubMed ID

  • 23162039

Pubmed Central ID

  • PMC4545047

Electronic International Standard Serial Number (EISSN)

  • 1757-790X

Digital Object Identifier (DOI)

  • 10.1136/bcr-2012-010508


  • eng

Conference Location

  • England