Skip to main content

Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.

Publication ,  Journal Article
Li, F; Zhang, P; Zhang, M; Liang, L; Sun, X; Li, M; Tang, Y; Bao, A; Gong, J; Zhang, J; Adcock, I; Chung, KF; Zhou, X
Published in: American journal of respiratory cell and molecular biology
July 2016

Hydrogen sulfide (H2S), a novel signaling gasotransmitter in the respiratory system, may have antiinflammatory properties in the lung. We examined the preventive and therapeutic effects of H2S on ozone-induced features of lung inflammation and emphysema. C57/BL6 mice were exposed to ozone or filtered air over 6 weeks. Sodium hydrogen sulfide (NaHS), an H2S donor, was administered to the mice either before ozone exposure (preventive effect) or after completion of 6 weeks of ozone exposure (therapeutic effect). The ozone-exposed mice developed emphysema, measured by micro-computed tomography and histology, airflow limitation, measured by the forced maneuver system, and increased lung inflammation with augmented IL-1β, IL-18, and matrix metalloproteinase-9 (MMP-9) gene expression. Ozone-induced changes were associated with increased Nod-like receptor pyrin domain containing 3 (NLRP3)-caspase-1 activation and p38 mitogen-activated protein kinase phosphorylation and decreased Akt phosphorylation. NaHS both prevented and reversed lung inflammation and emphysematous changes in alveolar space. In contrast, NaHS prevented, but did not reverse, ozone-induced airflow limitation and bronchial structural remodeling. In conclusion, NaHS administration prevented and partially reversed ozone-induced features of lung inflammation and emphysema via regulation of the NLRP3-caspase-1, p38 mitogen-activated protein kinase, and Akt pathways.

Duke Scholars

Published In

American journal of respiratory cell and molecular biology

DOI

EISSN

1535-4989

ISSN

1044-1549

Publication Date

July 2016

Volume

55

Issue

1

Start / End Page

72 / 81

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • X-Ray Microtomography
  • Respiratory System
  • Respiratory Function Tests
  • RNA, Messenger
  • Pulmonary Emphysema
  • Proto-Oncogene Proteins c-akt
  • Pneumonia
  • Phosphorylation
  • Ozone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, F., Zhang, P., Zhang, M., Liang, L., Sun, X., Li, M., … Zhou, X. (2016). Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. American Journal of Respiratory Cell and Molecular Biology, 55(1), 72–81. https://doi.org/10.1165/rcmb.2015-0014oc
Li, Feng, Pengyu Zhang, Min Zhang, Li Liang, Xiaoyuan Sun, Min Li, Yueqin Tang, et al. “Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.American Journal of Respiratory Cell and Molecular Biology 55, no. 1 (July 2016): 72–81. https://doi.org/10.1165/rcmb.2015-0014oc.
Li F, Zhang P, Zhang M, Liang L, Sun X, Li M, et al. Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. American journal of respiratory cell and molecular biology. 2016 Jul;55(1):72–81.
Li, Feng, et al. “Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.American Journal of Respiratory Cell and Molecular Biology, vol. 55, no. 1, July 2016, pp. 72–81. Epmc, doi:10.1165/rcmb.2015-0014oc.
Li F, Zhang P, Zhang M, Liang L, Sun X, Li M, Tang Y, Bao A, Gong J, Zhang J, Adcock I, Chung KF, Zhou X. Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. American journal of respiratory cell and molecular biology. 2016 Jul;55(1):72–81.

Published In

American journal of respiratory cell and molecular biology

DOI

EISSN

1535-4989

ISSN

1044-1549

Publication Date

July 2016

Volume

55

Issue

1

Start / End Page

72 / 81

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • X-Ray Microtomography
  • Respiratory System
  • Respiratory Function Tests
  • RNA, Messenger
  • Pulmonary Emphysema
  • Proto-Oncogene Proteins c-akt
  • Pneumonia
  • Phosphorylation
  • Ozone