The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.

Journal Article (Journal Article;Review)

Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. The goals of this task force review are as follows: This document is intended as a review of our understanding of chronic GVHD biology and therapies resulting from preclinical studies, and as a platform for developing innovative clinical strategies to prevent and treat chronic GVHD.

Full Text

Duke Authors

Cited Authors

  • Cooke, KR; Luznik, L; Sarantopoulos, S; Hakim, FT; Jagasia, M; Fowler, DH; van den Brink, MRM; Hansen, JA; Parkman, R; Miklos, DB; Martin, PJ; Paczesny, S; Vogelsang, G; Pavletic, S; Ritz, J; Schultz, KR; Blazar, BR

Published Date

  • February 2017

Published In

Volume / Issue

  • 23 / 2

Start / End Page

  • 211 - 234

PubMed ID

  • 27713092

Pubmed Central ID

  • PMC6020045

Electronic International Standard Serial Number (EISSN)

  • 1523-6536

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2016.09.023


  • eng

Conference Location

  • United States