The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease.
Journal Article (Journal Article;Review)
Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. The goals of this task force review are as follows: This document is intended as a review of our understanding of chronic GVHD biology and therapies resulting from preclinical studies, and as a platform for developing innovative clinical strategies to prevent and treat chronic GVHD.
Full Text
Duke Authors
Cited Authors
- Cooke, KR; Luznik, L; Sarantopoulos, S; Hakim, FT; Jagasia, M; Fowler, DH; van den Brink, MRM; Hansen, JA; Parkman, R; Miklos, DB; Martin, PJ; Paczesny, S; Vogelsang, G; Pavletic, S; Ritz, J; Schultz, KR; Blazar, BR
Published Date
- February 2017
Published In
Volume / Issue
- 23 / 2
Start / End Page
- 211 - 234
PubMed ID
- 27713092
Pubmed Central ID
- PMC6020045
Electronic International Standard Serial Number (EISSN)
- 1523-6536
Digital Object Identifier (DOI)
- 10.1016/j.bbmt.2016.09.023
Language
- eng
Conference Location
- United States