Stefanie Sarantopoulos | Scholars@Duke

Stefanie Sarantopoulos
Associate Professor of Medicine

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2018
Assistant Professor of Immunology, Immunology, Basic Science Departments 2015
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2013

Contact Information

152 Jones Bldg, Box 3961, Durham, NC 27710
152 Jones Bldg, Box 3961, Durham, NC 27710
stefanie.sarantopoulos@duke.edu
Investigator initiated clinical trial
bone marrow transplantation research funding AACR
clinical story
commentary in Blood about our work
philanthropic pursuits
podcast
press release re BAFF work
press release re lab work

Background
Education, Training, & Certifications
- Fellowship, Hematology/ Oncology, Dana Farber Cancer Institute 2002 - 2005
- Chief Resident, Internal Medicine, Boston University School of Medicine 2001 - 2002
- Resident, Internal Medicine, Boston University School of Medicine 1999 - 2001
- Intern, Internal Medicine, Boston University School of Medicine 1998 - 1999
- M.D., Boston University 1998
- Ph.D., Boston University School of Medicine 1998
Duke Appointment History
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2015 - 2018
- Assistant Research Professor in the Department of Immunology, Immunology, Basic Science Departments 2015
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2015
- Instructor, Temporary in the Department of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2013 - 2015
Leadership & Clinical Positions at Duke
- Head of Duke GVHD Multi-disciplinary ResearchCare Team
  MSTP admissions committee
  Hem/Onc Fellowship admissions committee
  Co-chair Duke Scholars in Molecular Medicine (Oncology)
Academic Positions Outside Duke
- Vice Chair ASH Scholar Award Review, The American Society of Hematology (ASH). 2018 - 2021
- Director of Laboratory Sciences, American Society of Bone Marrow Transplantation. 2018 - 2023
- Inductee, American Society of Clinical Investigation. 2017 - 2119
Research
Selected Grants
- Transfusion Medicine and Hematology awarded by National Institutes of Health 1975 - 2021
- A Phase II of Entospletinib, a SYK Inhibitor, First line cGVHD patients awarded by Gilead Sciences, Inc. 2016 - 2021
- Breaking B-Cell Tolerance to Produce Antibodies that Eradicate Leukemias and Lymphomas awarded by Department of Defense 2018 - 2020
- Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD awarded by National Institutes of Health 2015 - 2020
- The Notch2-BCR Axis: Targeting Drivers of B cell Fate in Chronic GVHD awarded by Leukemia & Lymphoma Society 2015 - 2019
- Understanding Aberrant TLR7 Signaling in B Cells from Patients with Chronic GVHD awarded by American Society for Blood and Marrow Transplantation 2018 - 2019
- The Effects of Syk Blockade with GS-9973 on Immunity in a Murine Model of GVHD awarded by Gilead Sciences, Inc. 2016 - 2018
- Improving Outcomes Assessment in cGVHD awarded by Fred Hutchinson Cancer Research Center 2015 - 2018
- UNC - Duke Immunotherapy Training Program awarded by University of North Carolina - Chapel Hill 2017 - 2018
- BAFF-Driven Targeted Immunotherapy for Patients with Leukemia awarded by Department of Defense 2011 - 2015
- BAFF Pathology: Novel Therapeutic Targets in Chronic Graft versus Host Disease awarded by National Institutes of Health 2011 - 2015
Fellowships, Supported Research, & Other Grants
- ASBMT Young Investigator Award awarded by American Society of Bone Marrow Transplantation 2018
- T32 Immunotherapy Duke-UNC awarded by NIH 2018
- Duke Scholar Award awarded by Duke University 2017
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Khera, N, Hamilton, BK, Pidala, JA, Wood, WA, Wu, V, Voutsinas, J, Onstad, L, Alousi, AM, Broady, R, Chen, GL, Arora, M, Cutler, C, Flowers, ME, Ganetsky, A, Jagasia, M, McCarthy, PL, Sarantopoulos, S, Abel, GA, Majhail, NS, and Lee, SJ. "Employment, Insurance, and Financial Experiences of Patients with Chronic Graft-versus-Host Disease in North America." October 5, 2018. Full Text
  - Anand, S, Thomas, S, Corbet, K, Gasparetto, C, Long, GD, Lopez, R, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Adult Umbilical Cord Blood Transplantation Using Myeloablative Thiotepa, Total Body Irradiation, and Fludarabine Conditioning." November 2017. Full Text
  - Poe, J, diPaolo, J, Jia, W, Kim, JY, Su, H, Reyes, N, Marcondes, AM, Saban, D, Cardona, D, Anand, S, Cardones, A, Chao, N, and Sarantopoulos, S. "Oral Syk inhibitor, Entospletinib (GS-9973), controls disease and enhances survival in a mouse model of chronic graft-versus host disease (cGVHD)." 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT). Marseille, FRANCE. March 26, 2017 - March 29, 2017.: NATURE PUBLISHING GROUP, July 1, 2017. Link to Item
  - Anand, S, Thomas, S, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sarantopoulos, S, Sullivan, KM, Sung, AD, Chao, NJ, and Horwitz, ME. "Adult Umbilical Cord Blood Transplantation Using Myeloablative Total Body Irradiation, Fludarabine, and Thiotepa Conditioning." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016. Link to Item
  - Jia, W, Poe, JC, Su, H, Matsushima, GK, Rathmell, J, Imai, K, Reyes, NJ, Cardona, DM, Anand, S, Deoliveira, D, Li, Z, Saban, DR, Chen, BJ, Chao, NJ, and Sarantopoulos, S. "Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd." December 2, 2016. Link to Item
  - Poe, JC, Jia, W, Su, H, Li, Z, Hakim, FT, Pavletic, SZ, Rose, JJ, Rizzieri, DA, Yang, Y, Chen, BJ, Anand, S, Ritz, J, Siebel, CW, Chao, NJ, Maillard, I, and Sarantopoulos, S. "All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016. Link to Item
  - Anand, S, Thomas, S, Hyslop, T, Corbet, K, Gasparetto, C, Long, G, Morris, A, Rizzieri, D, Sarantopoulos, S, Sullivan, K, Sung, A, Chao, N, and Horwitz, M. "Transplantation of Ex vivo Expanded Umbilical Cord Blood (Nicord) Results in Decreased Infection Burden and Hospital Length of Stay in the First 100 Days." March 2016. Link to Item
  - Friend, R, Xenakis, J, Serody, JS, Comeau, T, Gabriel, DA, Sarantopoulos, S, Coghill, J, Wood, WA, Sharf, A, Whitley, JS, Rao, K, Walko, CM, Ivanova, A, Shea, TC, and Armistead, PM. "Reduced Intensity Continuous Infusion Busulfan for Allogeneic Hematopoietic Cell Transplant Patients with Hematologic Disorders Who Are Ineligible or Inappropriate for Treatment with a More Intensive Therapeutic Regimen: LCCC 0306." December 3, 2015. Link to Item
  - Poe, JC, Jia, W, Li, Z, Hakim, FT, Pavletic, SZ, Rose, JJ, Rizzieri, DA, Yang, Y, Chen, BJ, Green, M, Anand, S, Siebel, CW, Maillard, I, Chao, NJ, and Sarantopoulos, S. "Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)." December 3, 2015. Link to Item
  - Fedoriw, Y, Cichon, L, Dokouhaki, P, Mathews, S, Sharf, A, and Sarantopoulos, S. "Delayed Reconstitution of Bone Marrow B Cell Precursors After Allogeneic Stem Cell Transplantation Is Associated With Chronic Graft Versus Host Disease (cGVHD)." February 2015. Link to Item
  - Fedoriw, Y, Cichon, L, Dokouhaki, P, Mathews, S, Sharf, A, and Sarantopoulos, S. "Delayed Reconstitution of Bone Marrow B Cell Precursors After Allogeneic Stem Cell Transplantation Is Associated With Chronic Graft Versus Host Disease (cGVHD)." February 2015. Link to Item
  - Green, MM, Horwitz, ME, Kang, Y, Chao, NJ, Long, GD, Rizzieri, D, Gasparetto, C, Sung, AD, Sarantopoulos, S, Li, Z, Corbet, K, Riggan-Stuelke, E, Sullivan, K, Wilson, B, Chhabra, S, Costa, LV, Mims, A, and Stuart, R. "Administration of Plerixafor (a CXCR4 antagonist) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Enhances Platelet Recovery in a Phase I/II Trial." February 2015. Full Text
  - Shea, TC, Walko, CM, Chung, Y, Ivanova, A, Rao, KV, Coghill, J, Sarantopoulos, S, Wood, WA, Armistead, P, Gabriel, DA, and Serody, JS. "Differential Impact of Dose Escalated Busulfan on Allogeneic Transplant for High, Intermediate and Low Risk Disease." February 2015. Full Text
  - Allen, JL, Fedoriw, G, Wooten, J, Fore, M, Roehrs, PA, Armistead, P, Coghill, J, Shea, TC, Richards, K, Lee, SJ, Rowe, K, Rizzieri, D, Chao, NJ, Serody, JS, and Sarantopoulos, S. "Increased BLNK and Syk in B Cells From Chronic Graft-Versus-Host Disease Patients: Identification of Novel Therapeutic Targets." February 2013. Full Text Link to Item
  - Wood, WA, Deal, AM, Battaglini, CL, Reeve, BB, Abernethy, AP, Kim, YH, Whitley, JS, Shatten, C, Irons, RN, Essenmacher, AN, Wehner, K, Pinto, A, Coghill, J, Armistead, PM, Sarantopoulos, S, Gabriel, DA, Serody, JS, and Shea, TC. "Feasibility and Prognostic Value of VO2(peak) in Patients Undergoing Hematopoietic Cell Transplantation (HCT)." November 16, 2012. Link to Item
  - Wood, WA, Deal, AM, Battaglini, CL, Reeve, BB, Abernethy, AP, Kim, YH, Whitley, JS, Shatten, C, Irons, RN, Essenmacher, AN, Wehner, K, Pinto, A, Coghill, J, Armistead, PM, Sarantopoulos, S, Gabriel, DA, Serody, JS, and Shea, TC. "Feasibility and Prognostic Value of VO2(peak) in Patients Undergoing Hematopoietic Cell Transplantation (HCT)." November 16, 2012. Link to Item
  - Wood, WA, Deal, AM, Reeve, BB, Abernethy, AP, Battaglini, CL, Kim, YH, Whitley, JS, Shatten, C, Irons, RN, Essenmacher, AN, Wehner, K, Pinto, A, Coghill, J, Armistead, PM, Sarantopoulos, S, Gabriel, DA, Serody, JS, and Shea, TC. "Feasibility of Daily and Weekly Symptom and Health-Related Quality of Life (HRQOL) Surveillance in Patients Receiving Hematopoietic Cell Transplantation (HCT)." November 16, 2012. Link to Item
- Journal Articles
  - Carpenter, PA, Logan, BR, Lee, SJ, Weisdorf, DJ, Johnston, L, Costa, LJ, Kitko, CL, Bolaños-Meade, J, Sarantopoulos, S, Alousi, AM, Abhyankar, S, Waller, EK, Mendizabal, A, Zhu, J, O'Brien, KA, Lazaryan, A, Wu, J, Nemecek, ER, Pavletic, SZ, Cutler, CS, Horowitz, MM, Arora, M, and BMT CTN., . "A phase II/III randomized, multicenter trial of prednisone/sirolimus versus prednisone/ sirolimus/calcineurin inhibitor for the treatment of chronic graft-versus-host disease: BMT CTN 0801." Haematologica 103, no. 11 (November 2018): 1915-1924. Full Text
  - Radojcic, V, Paz, K, Chung, J, Du, J, Perkey, ET, Flynn, R, Ivcevic, S, Zaiken, M, Friedman, A, Yan, M, Pletneva, MA, Sarantopoulos, S, Siebel, CW, Blazar, BR, and Maillard, I. "Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice." Blood 132, no. 20 (November 2018): 2188-2200. Full Text Open Access Copy
  - Poe, JC, Jia, W, Di Paolo, JA, Reyes, NJ, Kim, JY, Su, H, Sundy, JS, Cardones, AR, Perez, VL, Chen, BJ, Chao, NJ, Cardona, DM, Saban, DR, and Sarantopoulos, S. "SYK inhibitor entospletinib prevents ocular and skin GVHD in mice." Jci Insight 3, no. 19 (October 4, 2018). Full Text
  - Sullivan, KM, Majhail, NS, Bredeson, C, Carpenter, PA, Chatterjee, S, Crofford, LJ, Georges, GE, Nash, RA, Pasquini, MC, Sarantopoulos, S, Storek, J, Savani, B, and St Clair, EW. "Systemic Sclerosis as an Indication for Autologous Hematopoietic Cell Transplantation: Position Statement from the American Society for Blood and Marrow Transplantation." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 10 (October 2018): 1961-1964. Full Text Open Access Copy
  - Kolupaev, OV, Dant, TA, Bommiasamy, H, Bruce, DW, Fowler, KA, Tilley, SL, McKinnon, KP, Sarantopoulos, S, Blazar, BR, Coghill, JM, and Serody, JS. "Impaired bone marrow B-cell development in mice with a bronchiolitis obliterans model of cGVHD." Blood Advances 2, no. 18 (September 18, 2018): 2307-2319. Full Text Open Access Copy
  - Wolff, D, Greinix, H, Lee, SJ, Gooley, T, Paczesny, S, Pavletic, S, Hakim, F, Malard, F, Jagasia, M, Lawitschka, A, Hansen, JA, Pulanic, D, Holler, E, Dickinson, A, Weissinger, E, Edinger, M, Sarantopoulos, S, and Schultz, KR. "Biomarkers in chronic graft-versus-host disease: quo vadis?." Bone Marrow Transplantation 53, no. 7 (July 2018): 832-837. Full Text
  - Anand, S, and Sarantopoulos, S. "Chronic Graft-versus-Host Disease: A Long Road Ahead." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 3 (March 2018): 423-424. Full Text
  - Zeiser, R, Sarantopoulos, S, and Blazar, BR. "B-cell targeting in chronic graft-versus-host disease." Blood 131, no. 13 (March 2018): 1399-1405. (Review) Full Text Open Access Copy
  - Lee, SJ, Hamilton, BK, Pidala, J, Alousi, A, Kurukulasuriya, C, Onstad, L, Jagasia, M, Chen, G, Cutler, C, Broady, R, Arora, M, Arai, S, Sarantopoulos, S, and Flowers, ME. "Design and Patient Characteristics of the Chronic Graft-versus-Host Disease Response Measures Validation Study." Biology of Blood and Marrow Transplantation (February 2018). Full Text
  - Sarantopoulos, S. "Allogeneic Stem-Cell Transplantation - A T-Cell Balancing ACT." The New England Journal of Medicine 378, no. 5 (February 2018): 480-482. Full Text
  - Poe, JC, Jia, W, Su, H, Anand, S, Rose, JJ, Tata, PV, Suthers, AN, Jones, CD, Kuan, PF, Vincent, BG, Serody, JS, Horwitz, ME, Ho, VT, Pavletic, SZ, Hakim, FT, Owzar, K, Zhang, D, Blazar, BR, Siebel, CW, Chao, NJ, Maillard, I, and Sarantopoulos, S. "An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD." Blood 130, no. 19 (November 2017): 2131-2145. Full Text
  - Anand, S, Thomas, S, Hyslop, T, Adcock, J, Corbet, K, Gasparetto, C, Lopez, R, Long, GD, Morris, AK, Rizzieri, DA, Sullivan, KM, Sung, AD, Sarantopoulos, S, Chao, NJ, and Horwitz, ME. "Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 23, no. 7 (July 2017): 1151-1157. Full Text
  - Saliba, RM, Sarantopoulos, S, Kitko, CL, Pawarode, A, Goldstein, SC, Magenau, J, Alousi, AM, Churay, T, Justman, H, Paczesny, S, Reddy, P, and Couriel, DR. "B-cell activating factor (BAFF) plasma level at the time of chronic GvHD diagnosis is a potential predictor of non-relapse mortality." Bone marrow transplantation 52, no. 7 (July 2017): 1010-1015. Full Text
  - Gea-Banacloche, J, Komanduri, KV, Carpenter, P, Paczesny, S, Sarantopoulos, S, Young, J-A, El Kassar, N, Le, RQ, Schultz, KR, Griffith, LM, Savani, BN, and Wingard, JR. "National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Immune Dysregulation and Pathobiology Working Group Report." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 23, no. 6 (June 2017): 870-881. (Review) Full Text
  - Cooke, KR, Luznik, L, Sarantopoulos, S, Hakim, FT, Jagasia, M, Fowler, DH, van den Brink, MRM, Hansen, JA, Parkman, R, Miklos, DB, Martin, PJ, Paczesny, S, Vogelsang, G, Pavletic, S, Ritz, J, Schultz, KR, and Blazar, BR. "The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 23, no. 2 (February 2017): 211-234. (Review) Full Text
  - Sivaraj, D, Green, MM, Li, Z, Sung, AD, Sarantopoulos, S, Kang, Y, Long, GD, Horwitz, ME, Lopez, RD, Sullivan, KM, Rizzieri, DA, Chao, NJ, and Gasparetto, C. "Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 23, no. 2 (February 2017): 262-268. Full Text
  - Suthers, AN, and Sarantopoulos, S. "TLR7/TLR9- and B Cell Receptor-Signaling Crosstalk: Promotion of Potentially Dangerous B Cells." Frontiers in Immunology 8 (January 2017): 775-null. (Review) Full Text
  - Sullivan, KM, Shah, A, Sarantopoulos, S, and Furst, DE. "Review: Hematopoietic Stem Cell Transplantation for Scleroderma: Effective Immunomodulatory Therapy for Patients With Pulmonary Involvement." Arthritis & Rheumatology (Hoboken, N.J.) 68, no. 10 (October 2016): 2361-2371. (Review) Full Text Open Access Copy
  - Green, MMB, Chao, N, Chhabra, S, Corbet, K, Gasparetto, C, Horwitz, A, Li, Z, Venkata, JK, Long, G, Mims, A, Rizzieri, D, Sarantopoulos, S, Stuart, R, Sung, AD, Sullivan, KM, Costa, L, Horwitz, M, and Kang, Y. "Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery." Journal of Hematology & Oncology 9, no. 1 (August 17, 2016): 71-null. Full Text Open Access Copy
  - Sarantopoulos, S. "Antibodies are back for thymic attack in cGVHD." Blood 127, no. 18 (May 2016): 2170-2171. Full Text Open Access Copy
  - Yang, Y, Poe, JC, Yang, L, Fedoriw, A, Desai, S, Magnuson, T, Li, Z, Fedoriw, Y, Araki, K, Gao, Y, Tateishi, S, Sarantopoulos, S, and Vaziri, C. "Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo." Nucleic Acids Research 44, no. 9 (May 2016): 4174-4188. Full Text Open Access Copy
  - DeFilipp, Z, Purcell, M, Harris, WAC, Chandra, DJ, Gleason, C, Wrammert, J, Sarantopoulos, S, and Waller, EK. "Monitoring the kinetics of B-cell recovery following rituximab may guide the management of steroid-refractory chronic GvHD." Bone marrow transplantation 51, no. 4 (April 2016): 607-609. (Letter) Full Text
  - Arai, S, Pidala, J, Pusic, I, Chai, X, Jaglowski, S, Khera, N, Palmer, J, Chen, GL, Jagasia, MH, Mayer, SA, Wood, WA, Green, M, Hyun, TS, Inamoto, Y, Storer, BE, Miklos, DB, Shulman, HM, Martin, PJ, Sarantopoulos, S, Lee, SJ, and Flowers, MED. "A Randomized Phase II Crossover Study of Imatinib or Rituximab for Cutaneous Sclerosis after Hematopoietic Cell Transplantation." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 22, no. 2 (January 2016): 319-327. Full Text Open Access Copy
  - Shea, TC, Walko, C, Chung, Y, Ivanova, A, Sheets, J, Rao, K, Gabriel, D, Comeau, T, Wood, W, Coghill, J, Armistead, P, Sarantopoulos, S, and Serody, J. "Phase I/II Trial of Dose-Escalated Busulfan Delivered by Prolonged Continuous Infusion in Allogeneic Transplant Patients." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 21, no. 12 (December 2015): 2129-2135. Full Text
  - Baird, K, Comis, LE, Joe, GO, Steinberg, SM, Hakim, FT, Rose, JJ, Mitchell, SA, Pavletic, SZ, Figg, WD, Yao, L, Flanders, KC, Takebe, N, Sarantopoulos, S, Booher, S, and Cowen, EW. "Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 21, no. 6 (June 2015): 1083-1090. Full Text
  - Flynn, R, Allen, JL, Luznik, L, MacDonald, KP, Paz, K, Alexander, KA, Vulic, A, Du, J, Panoskaltsis-Mortari, A, Taylor, PA, Poe, JC, Serody, JS, Murphy, WJ, Hill, GR, Maillard, I, Koreth, J, Cutler, CS, Soiffer, RJ, Antin, JH, Ritz, J, Chao, NJ, Clynes, RA, Sarantopoulos, S, and Blazar, BR. "Targeting Syk-activated B cells in murine and human chronic graft-versus-host disease." Blood 125, no. 26 (June 2015): 4085-4094. Full Text
  - Hunsucker, SA, McGary, CS, Vincent, BG, Enyenihi, AA, Waugh, JP, McKinnon, KP, Bixby, LM, Ropp, PA, Coghill, JM, Wood, WA, Gabriel, DA, Sarantopoulos, S, Shea, TC, Serody, JS, Alatrash, G, Rodriguez-Cruz, T, Lizée, G, Buntzman, AS, Frelinger, JA, Glish, GL, and Armistead, PM. "Peptide/MHC tetramer-based sorting of CD8⁺ T cells to a leukemia antigen yields clonotypes drawn nonspecifically from an underlying restricted repertoire." Cancer immunology research 3, no. 3 (March 2015): 228-235. Full Text
  - Sarantopoulos, S, and Ritz, J. "Aberrant B-cell homeostasis in chronic GVHD." Blood 125, no. 11 (March 2015): 1703-1707. (Review) Full Text
  - Sarantopoulos, S, Blazar, BR, Cutler, C, and Ritz, J. "Reprint of: B cells in chronic graft-versus-host disease." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 21, no. 2 Suppl (February 2015): S11-S18. (Review) Full Text
  - Sarantopoulos, S, Blazar, BR, Cutler, C, and Ritz, J. "B cells in chronic graft-versus-host disease." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 21, no. 1 (January 2015): 16-23. (Review) Full Text
  - Flynn, R, Du, J, Veenstra, RG, Reichenbach, DK, Panoskaltsis-Mortari, A, Taylor, PA, Freeman, GJ, Serody, JS, Murphy, WJ, Munn, DH, Sarantopoulos, S, Luznik, L, Maillard, I, Koreth, J, Cutler, C, Soiffer, RJ, Antin, JH, Ritz, J, Dubovsky, JA, Byrd, JC, MacDonald, KP, Hill, GR, and Blazar, BR. "Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans." Blood 123, no. 25 (June 2014): 3988-3998. Full Text
  - Jacobson, CA, Sun, L, Kim, HT, McDonough, SM, Reynolds, CG, Schowalter, M, Koreth, J, Cutler, CS, Ho, VT, Alyea, EP, Armand, P, Blazar, BR, Soiffer, RJ, Antin, JH, Ritz, J, and Sarantopoulos, S. "Post-transplantation B cell activating factor and B cell recovery before onset of chronic graft-versus-host disease." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 20, no. 5 (May 2014): 668-675. Full Text
  - Allen, JL, Tata, PV, Fore, MS, Wooten, J, Rudra, S, Deal, AM, Sharf, A, Hoffert, T, Roehrs, PA, Shea, TC, Serody, JS, Richards, KL, Jagasia, M, Lee, SJ, Rizzieri, D, Horwitz, ME, Chao, NJ, and Sarantopoulos, S. "Increased BCR responsiveness in B cells from patients with chronic GVHD." Blood 123, no. 13 (March 2014): 2108-2115. Full Text
  - Sarantopoulos, S, and Su, MA. "BAFF-ling autoantibodies." The Journal of Clinical Investigation 123, no. 12 (December 2013): 5006-5008. Full Text
  - Cutler, C, Kim, HT, Bindra, B, Sarantopoulos, S, Ho, VT, Chen, Y-B, Rosenblatt, J, McDonough, S, Watanaboonyongcharoen, P, Armand, P, Koreth, J, Glotzbecker, B, Alyea, E, Blazar, BR, Soiffer, RJ, Ritz, J, and Antin, JH. "Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial." Blood 122, no. 8 (August 2013): 1510-1517. Full Text
  - Wood, WA, Whitley, J, Goyal, R, Brown, PM, Sharf, A, Irons, R, Rao, KV, Essenmacher, A, Serody, JS, Coghill, JM, Armistead, PM, Sarantopoulos, S, Gabriel, DA, and Shea, TC. "Effectiveness of etoposide chemomobilization in lymphoma patients undergoing auto-SCT." Bone Marrow Transplantation 48, no. 6 (June 2013): 771-776. Full Text
  - Allen, JL, Fore, MS, Wooten, J, Roehrs, PA, Bhuiya, NS, Hoffert, T, Sharf, A, Deal, AM, Armistead, P, Coghill, J, Gabriel, DA, Irons, R, Essenmacher, A, Shea, TC, Richards, K, Cutler, C, Ritz, J, Serody, J, Baldwin, AS, and Sarantopoulos, S. "B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways." Blood 120, no. 12 (September 2012): 2529-2536. Full Text
  - Fore, M, Jagasia, M, Sarantopoulos, S, and Richards, KL. "Further examination of BAFF SNPs in cGVHD." Blood 120, no. 3 (July 2012): 700-701. (Letter) Full Text
  - Fedoriw, Y, Samulski, TD, Deal, AM, Dunphy, CH, Sharf, A, Shea, TC, Serody, JS, and Sarantopoulos, S. "Bone marrow B cell precursor number after allogeneic stem cell transplantation and GVHD development." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 18, no. 6 (June 2012): 968-973. Full Text
  - Levine, JE, Paczesny, S, and Sarantopoulos, S. "Clinical applications for biomarkers of acute and chronic graft-versus-host disease." Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 18, no. 1 Suppl (January 2012): S116-S124. (Review) Full Text
  - Porcheray, F, Miklos, DB, Floyd, BH, Sarantopoulos, S, Bellucci, R, Soiffer, RJ, Antin, JH, Alyea, EP, Ritz, J, and Zorn, E. "Combined CD4 T-cell and antibody response to human minor histocompatibility antigen DBY after allogeneic stem-cell transplantation." Transplantation 92, no. 3 (August 2011): 359-365. Full Text
  - Coghill, JM, Sarantopoulos, S, Moran, TP, Murphy, WJ, Blazar, BR, and Serody, JS. "Effector CD4+ T cells, the cytokines they generate, and GVHD: something old and something new." Blood 117, no. 12 (March 2011): 3268-3276. (Review) Full Text
  - Sarantopoulos, S, Stevenson, KE, Kim, HT, Washel, WS, Bhuiya, NS, Cutler, CS, Alyea, EP, Ho, VT, Soiffer, RJ, Antin, JH, and Ritz, J. "Recovery of B-cell homeostasis after rituximab in chronic graft-versus-host disease." Blood 117, no. 7 (February 2011): 2275-2283. Full Text
  - Armistead, PM, Liang, S, Li, H, Lu, S, Van Bergen, CAM, Alatrash, G, St John, L, Hunsucker, SA, Sarantopoulos, S, Falkenburg, JHF, and Molldrem, JJ. "Common minor histocompatibility antigen discovery based upon patient clinical outcomes and genomic data." PloS one 6, no. 8 (January 2011): e23217-. Full Text
  - Ofran, Y, Kim, HT, Brusic, V, Blake, L, Mandrell, M, Wu, CJ, Sarantopoulos, S, Bellucci, R, Keskin, DB, Soiffer, RJ, Antin, JH, and Ritz, J. "Diverse patterns of T-cell response against multiple newly identified human Y chromosome-encoded minor histocompatibility epitopes." Clinical cancer research : an official journal of the American Association for Cancer Research 16, no. 5 (March 2010): 1642-1651. Full Text
  - Ho, VT, Vanneman, M, Kim, H, Sasada, T, Kang, YJ, Pasek, M, Cutler, C, Koreth, J, Alyea, E, Sarantopoulos, S, Antin, JH, Ritz, J, Canning, C, Kutok, J, Mihm, MC, Dranoff, G, and Soiffer, R. "Biologic activity of irradiated, autologous, GM-CSF-secreting leukemia cell vaccines early after allogeneic stem cell transplantation." Proceedings of the National Academy of Sciences of the United States of America 106, no. 37 (September 2009): 15825-15830. Full Text
  - Sarantopoulos, S, Stevenson, KE, Kim, HT, Cutler, CS, Bhuiya, NS, Schowalter, M, Ho, VT, Alyea, EP, Koreth, J, Blazar, BR, Soiffer, RJ, Antin, JH, and Ritz, J. "Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease." Blood 113, no. 16 (April 2009): 3865-3874. Full Text
  - Sittler, T, Zhou, J, Park, J, Yuen, NK, Sarantopoulos, S, Mollick, J, Salgia, R, Giobbie-Hurder, A, Dranoff, G, and Hodi, FS. "Concerted potent humoral immune responses to autoantigens are associated with tumor destruction and favorable clinical outcomes without autoimmunity." Clinical cancer research : an official journal of the American Association for Cancer Research 14, no. 12 (June 2008): 3896-3905. Full Text
  - Sarantopoulos, S, Stevenson, KE, Kim, HT, Bhuiya, NS, Cutler, CS, Soiffer, RJ, Antin, JH, and Ritz, J. "High levels of B-cell activating factor in patients with active chronic graft-versus-host disease." Clinical cancer research : an official journal of the American Association for Cancer Research 13, no. 20 (October 2007): 6107-6114. Full Text
  - Sarantopoulos, S, Lu, L, and Cantor, H. "Qa-1 restriction of CD8+ suppressor T cells." The Journal of clinical investigation 114, no. 9 (November 2004): 1218-1221. (Review) Full Text
  - Lin, NU, Sarantopoulos, S, Stone, JR, Galinsky, I, Stone, RM, Deangelo, DJ, and Soiffer, RJ. "Fatal hepatic necrosis following imatinib mesylate therapy." Blood 102, no. 9 (November 2003): 3455-3456. (Letter) Full Text
  - Sharon, J, Sompuram, SR, Yang, C-Y, Williams, BR, and Sarantopoulos, S. "Construction of polyclonal antibody libraries using phage display." Methods in molecular biology (Clifton, N.J.) 178 (January 2002): 101-112. (Review)
  - Sharon, J, Sarantopoulos, S, Den, W, Kao, CY, Baecher-Allan, CM, Santora, KE, Sompuram, SR, Petersen-Mahrt, S, and Williams, BR. "Recombinant polyclonal antibody libraries." Combinatorial chemistry & high throughput screening 3, no. 3 (June 2000): 185-196. (Review) Full Text
  - Santora, KE, Sarantopoulos, S, Den, W, Petersen-Mahrt, S, Sompuram, SR, and Sharon, J. "Generation of a polyclonal fab phage display library to the human breast carcinoma cell line BT-20." Combinatorial chemistry & high throughput screening 3, no. 1 (February 2000): 51-57. Full Text
  - Baecher-Allan, CM, Santora, K, Sarantopoulos, S, Den, W, Sompuram, SR, Sharon, J, Cevallos, AM, Bhat, N, and Ward, H. "Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum." Combinatorial chemistry & high throughput screening 2, no. 6 (December 1999): 319-325.
  - Den, W, Sompuram, SR, Sarantopoulos, S, and Sharon, J. "A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries." Journal of immunological methods 222, no. 1-2 (January 1999): 45-57. Full Text
  - Sarantopoulos, S, Kao, CY, Den, W, and Sharon, J. "A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries." Journal of immunology (Baltimore, Md. : 1950) 152, no. 11 (June 1994): 5344-5351.
  - Moyer, CF, Huggins, E, Sarantopoulos, S, Lewis, JC, Sajuthi, D, Biron, CA, and Reinisch, CL. "Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells." Experimental cell research 199, no. 1 (March 1992): 63-73. Full Text

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Education, Training, & Certifications

Duke Appointment History

Leadership & Clinical Positions at Duke

Academic Positions Outside Duke

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Selected Publications

Conference Papers

Journal Articles