Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma.

Published

Journal Article

We performed a genome-wide association study for primary open-angle glaucoma (POAG) in 1,007 cases with high-pressure glaucoma (HPG) and 1,009 controls from southern China. We observed genome-wide significant association at multiple SNPs near ABCA1 at 9q31.1 (rs2487032; P = 1.66 × 10(-8)) and suggestive evidence of association in PMM2 at 16p13.2 (rs3785176; P = 3.18 × 10(-6)). We replicated these findings in a set of 525 HPG cases and 912 controls from Singapore and a further set of 1,374 POAG cases and 4,053 controls from China. We observed genome-wide significant association with more than one SNP at the two loci (P = 2.79 × 10(-19) for rs2487032 representing ABCA1 and P = 5.77 × 10(-10) for rs3785176 representing PMM2). Both ABCA1 and PMM2 are expressed in the trabecular meshwork, optic nerve and other ocular tissues. In addition, ABCA1 is highly expressed in the ganglion cell layer of the retina, a finding consistent with it having a role in the development of glaucoma.

Full Text

Duke Authors

Cited Authors

  • Chen, Y; Lin, Y; Vithana, EN; Jia, L; Zuo, X; Wong, TY; Chen, LJ; Zhu, X; Tam, POS; Gong, B; Qian, S; Li, Z; Liu, X; Mani, B; Luo, Q; Guzman, C; Leung, CKS; Li, X; Cao, W; Yang, Q; Tham, CCY; Cheng, Y; Zhang, X; Wang, N; Aung, T; Khor, CC; Pang, CP; Sun, X; Yang, Z

Published Date

  • October 2014

Published In

Volume / Issue

  • 46 / 10

Start / End Page

  • 1115 - 1119

PubMed ID

  • 25173107

Pubmed Central ID

  • 25173107

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng.3078

Language

  • eng