Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes.
Journal Article (Journal Article)
Changes in retinal geometric parameters predict risk and progression of diabetic retinopathy (DR). We have shown that vitamin D deficiency (VDD) is associated with DR. We hypothesized that VDD mediates changes in retinal geometric parameters. Retinal vascular geometric parameters were assessed using a semiautomated computer program in photographs from young people with type 1 diabetes (T1D) (n = 481) and summarized as central retinal arteriolar and venular equivalents (CRAE, CRVE), fractal dimension, length-diameter ratio, branching angle and curvature tortuosity. Parameters were compared between those with and without DR and VDD (25-hydroxyvitamin D concentration ≤ 50 nmol/L). Retinal vascular geometric parameters were also compared across quartiles of vitamin D levels. Median CRVE was higher in patients with DR compared with those without (median (IQR) CRVE 247.3 μ m (31.3) versus 238.8 μ m (23.5), P = 0.01). Fractal dimension was marginally greater in patients without VDD (1.49 (0.06) versus 1.47 (0.07) P = 0.03). There was no difference in CRAE, CRVE, length-diameter ratio, branching angle, and curvature tortuosity between those with and without VDD and across quartiles of 25OHD. In conclusion, DR is associated with higher CRVE in young people with T1D; however, VDD is not associated with changes in retinal vascular geometric measures, suggesting an earlier role in the time course of DR pathogenesis.
Full Text
Duke Authors
Cited Authors
- Poon, M; Craig, ME; Kaur, H; Cusumano, J; Sasongko, MB; Wong, TY; Donaghue, KC
Published Date
- 2013
Published In
Volume / Issue
- 2013 /
Start / End Page
- 280691 -
PubMed ID
- 23936865
Pubmed Central ID
- PMC3723242
International Standard Serial Number (ISSN)
- 2314-6745
Digital Object Identifier (DOI)
- 10.1155/2013/280691
Language
- eng
Conference Location
- England