Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes.

Published

Journal Article

Changes in retinal geometric parameters predict risk and progression of diabetic retinopathy (DR). We have shown that vitamin D deficiency (VDD) is associated with DR. We hypothesized that VDD mediates changes in retinal geometric parameters. Retinal vascular geometric parameters were assessed using a semiautomated computer program in photographs from young people with type 1 diabetes (T1D) (n = 481) and summarized as central retinal arteriolar and venular equivalents (CRAE, CRVE), fractal dimension, length-diameter ratio, branching angle and curvature tortuosity. Parameters were compared between those with and without DR and VDD (25-hydroxyvitamin D concentration ≤ 50 nmol/L). Retinal vascular geometric parameters were also compared across quartiles of vitamin D levels. Median CRVE was higher in patients with DR compared with those without (median (IQR) CRVE 247.3  μ m (31.3) versus 238.8  μ m (23.5), P = 0.01). Fractal dimension was marginally greater in patients without VDD (1.49 (0.06) versus 1.47 (0.07) P = 0.03). There was no difference in CRAE, CRVE, length-diameter ratio, branching angle, and curvature tortuosity between those with and without VDD and across quartiles of 25OHD. In conclusion, DR is associated with higher CRVE in young people with T1D; however, VDD is not associated with changes in retinal vascular geometric measures, suggesting an earlier role in the time course of DR pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Poon, M; Craig, ME; Kaur, H; Cusumano, J; Sasongko, MB; Wong, TY; Donaghue, KC

Published Date

  • 2013

Published In

Volume / Issue

  • 2013 /

Start / End Page

  • 280691 -

PubMed ID

  • 23936865

Pubmed Central ID

  • 23936865

International Standard Serial Number (ISSN)

  • 2314-6745

Digital Object Identifier (DOI)

  • 10.1155/2013/280691

Language

  • eng

Conference Location

  • Egypt