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Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes.

Publication ,  Journal Article
Poon, M; Craig, ME; Kaur, H; Cusumano, J; Sasongko, MB; Wong, TY; Donaghue, KC
Published in: J Diabetes Res
2013

Changes in retinal geometric parameters predict risk and progression of diabetic retinopathy (DR). We have shown that vitamin D deficiency (VDD) is associated with DR. We hypothesized that VDD mediates changes in retinal geometric parameters. Retinal vascular geometric parameters were assessed using a semiautomated computer program in photographs from young people with type 1 diabetes (T1D) (n = 481) and summarized as central retinal arteriolar and venular equivalents (CRAE, CRVE), fractal dimension, length-diameter ratio, branching angle and curvature tortuosity. Parameters were compared between those with and without DR and VDD (25-hydroxyvitamin D concentration ≤ 50 nmol/L). Retinal vascular geometric parameters were also compared across quartiles of vitamin D levels. Median CRVE was higher in patients with DR compared with those without (median (IQR) CRVE 247.3  μ m (31.3) versus 238.8  μ m (23.5), P = 0.01). Fractal dimension was marginally greater in patients without VDD (1.49 (0.06) versus 1.47 (0.07) P = 0.03). There was no difference in CRAE, CRVE, length-diameter ratio, branching angle, and curvature tortuosity between those with and without VDD and across quartiles of 25OHD. In conclusion, DR is associated with higher CRVE in young people with T1D; however, VDD is not associated with changes in retinal vascular geometric measures, suggesting an earlier role in the time course of DR pathogenesis.

Duke Scholars

Published In

J Diabetes Res

DOI

ISSN

2314-6745

Publication Date

2013

Volume

2013

Start / End Page

280691

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Retinal Vein
  • Retinal Artery
  • Retina
  • Male
  • Humans
  • Female
  • Disease Progression
  • Diabetic Retinopathy
 

Citation

APA
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ICMJE
MLA
NLM
Poon, M., Craig, M. E., Kaur, H., Cusumano, J., Sasongko, M. B., Wong, T. Y., & Donaghue, K. C. (2013). Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes. J Diabetes Res, 2013, 280691. https://doi.org/10.1155/2013/280691
Poon, Myra, Maria E. Craig, Harleen Kaur, Janine Cusumano, Muhammad Bayu Sasongko, Tien Yin Wong, and Kim C. Donaghue. “Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes.J Diabetes Res 2013 (2013): 280691. https://doi.org/10.1155/2013/280691.
Poon M, Craig ME, Kaur H, Cusumano J, Sasongko MB, Wong TY, et al. Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes. J Diabetes Res. 2013;2013:280691.
Poon, Myra, et al. “Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes.J Diabetes Res, vol. 2013, 2013, p. 280691. Pubmed, doi:10.1155/2013/280691.
Poon M, Craig ME, Kaur H, Cusumano J, Sasongko MB, Wong TY, Donaghue KC. Vitamin D deficiency is not associated with changes in retinal geometric parameters in young people with type 1 diabetes. J Diabetes Res. 2013;2013:280691.
Journal cover image

Published In

J Diabetes Res

DOI

ISSN

2314-6745

Publication Date

2013

Volume

2013

Start / End Page

280691

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Retinal Vein
  • Retinal Artery
  • Retina
  • Male
  • Humans
  • Female
  • Disease Progression
  • Diabetic Retinopathy