Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study.

Journal Article (Journal Article)

AIM: To examine retinal vessel calibre in autoimmune rheumatic disease. MATERIALS AND METHODS: Patients with autoimmune rheumatic disease were recruited from a Rheumatology clinic. Retinal vessel calibre was measured from fundus photographs, and summarised as the central retinal artery and vein equivalents (CRAE and CRVE) using a semi-automated computer-assisted method. RESULTS: The 124 patients studied had rheumatoid arthritis (n = 76, 61%), systemic lupus erythematosus (n = 17, 14%), psoriatic arthritis (n = 11, 9%) or another rheumatological disease (n = 20, 16%). Retinal venular calibre was increased in patients with autoimmune rheumatic disease (+11.6 µm, 95% Confidence interval [CI] 3.8 - 19.3, p = 0.01) compared with other hospital patients, after adjusting for baseline differences. This increase was also present in the subgroup with rheumatoid arthritis (p = 0.01). Patients with a rheumatic disease and elevated C-reactive protein (CRP) levels had wider retinal venules than those with a lower CRP (mean CRVE: 247.8 ± 28.0 versus 216.6 ± 25.3, p < 0.01), and than other hospital patients with increased CRP (mean CRVE: 247.8 ± 28.0 versus 216.4 ± 25.9, p < 0.01). CONCLUSIONS: Individuals with an autoimmune rheumatic disease have wider retinal venules than other hospital patients. This increase in calibre may be due to the underlying inflammatory activity.

Full Text

Duke Authors

Cited Authors

  • Okada, M; Wong, TY; Kawasaki, R; Baharuddin, NB; Colville, D; Buchanan, R; Savige, J

Published Date

  • June 2013

Published In

Volume / Issue

  • 38 / 6

Start / End Page

  • 685 - 690

PubMed ID

  • 23654356

Electronic International Standard Serial Number (EISSN)

  • 1460-2202

Digital Object Identifier (DOI)

  • 10.3109/02713683.2012.754046


  • eng

Conference Location

  • England