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Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study.

Publication ,  Journal Article
Okada, M; Wong, TY; Kawasaki, R; Baharuddin, NB; Colville, D; Buchanan, R; Savige, J
Published in: Curr Eye Res
June 2013

AIM: To examine retinal vessel calibre in autoimmune rheumatic disease. MATERIALS AND METHODS: Patients with autoimmune rheumatic disease were recruited from a Rheumatology clinic. Retinal vessel calibre was measured from fundus photographs, and summarised as the central retinal artery and vein equivalents (CRAE and CRVE) using a semi-automated computer-assisted method. RESULTS: The 124 patients studied had rheumatoid arthritis (n = 76, 61%), systemic lupus erythematosus (n = 17, 14%), psoriatic arthritis (n = 11, 9%) or another rheumatological disease (n = 20, 16%). Retinal venular calibre was increased in patients with autoimmune rheumatic disease (+11.6 µm, 95% Confidence interval [CI] 3.8 - 19.3, p = 0.01) compared with other hospital patients, after adjusting for baseline differences. This increase was also present in the subgroup with rheumatoid arthritis (p = 0.01). Patients with a rheumatic disease and elevated C-reactive protein (CRP) levels had wider retinal venules than those with a lower CRP (mean CRVE: 247.8 ± 28.0 versus 216.6 ± 25.3, p < 0.01), and than other hospital patients with increased CRP (mean CRVE: 247.8 ± 28.0 versus 216.4 ± 25.9, p < 0.01). CONCLUSIONS: Individuals with an autoimmune rheumatic disease have wider retinal venules than other hospital patients. This increase in calibre may be due to the underlying inflammatory activity.

Duke Scholars

Published In

Curr Eye Res

DOI

EISSN

1460-2202

Publication Date

June 2013

Volume

38

Issue

6

Start / End Page

685 / 690

Location

England

Related Subject Headings

  • Venules
  • Retinal Vein
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Female
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Okada, M., Wong, T. Y., Kawasaki, R., Baharuddin, N. B., Colville, D., Buchanan, R., & Savige, J. (2013). Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study. Curr Eye Res, 38(6), 685–690. https://doi.org/10.3109/02713683.2012.754046
Okada, Mali, Tien Y. Wong, Ryo Kawasaki, Norasyiqin Binti Baharuddin, Deb Colville, Russell Buchanan, and Judy Savige. “Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study.Curr Eye Res 38, no. 6 (June 2013): 685–90. https://doi.org/10.3109/02713683.2012.754046.
Okada M, Wong TY, Kawasaki R, Baharuddin NB, Colville D, Buchanan R, et al. Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study. Curr Eye Res. 2013 Jun;38(6):685–90.
Okada, Mali, et al. “Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study.Curr Eye Res, vol. 38, no. 6, June 2013, pp. 685–90. Pubmed, doi:10.3109/02713683.2012.754046.
Okada M, Wong TY, Kawasaki R, Baharuddin NB, Colville D, Buchanan R, Savige J. Retinal venular calibre is increased in patients with autoimmune rheumatic disease: a case-control study. Curr Eye Res. 2013 Jun;38(6):685–690.

Published In

Curr Eye Res

DOI

EISSN

1460-2202

Publication Date

June 2013

Volume

38

Issue

6

Start / End Page

685 / 690

Location

England

Related Subject Headings

  • Venules
  • Retinal Vein
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Female
  • Case-Control Studies