Structural changes in the retinal microvasculature and renal function.

Published

Journal Article

PURPOSE: To evaluate the associations between chronic kidney disease (CKD) and microalbuminuria, and a comprehensive range of retinal microvascular abnormalities including traditional and new retinal vascular measures. METHODS: This was a population-based, cross-sectional study on 3280 urban Malay adults. The albumin/creatinine ratio (ACR) was calculated from spot urine samples. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentration. Retinal vascular caliber and geometry were quantified from retinal fundus photographs using a semiautomated computer-assisted program. Qualitative changes including focal arteriolar narrowing, arteriovenous nicking, and opacification of the arteriolar wall were assessed by trained graders. RESULTS: In multivariate analyses adjusting for age, sex, hypertension, diabetes, and smoking, narrower retinal arteriolar caliber (P = 0.008), smaller retinal vascular fractal dimensions (P = 0.014), and the presence of AV nicking and opacification (P = 0.005 and P < 0.001, respectively) were significantly associated with lower eGFR. In multivariate adjusted logistic regression analyses, none of the retinal markers was associated with CKD. A smaller fractal dimension (P < 0.001) and the presence of focal arteriolar narrowing, AV nicking and opacification were associated with higher ACR (P < 0.001, P = 0.01, and P = 0.002, respectively). Narrower retinal arterioles (P = 0.041); smaller fractal dimensions (P = 0.006); and focal arteriolar narrowing, AV nicking, and opacification (P = 0.007, P = 0.007, and P = 0.012, respectively) were associated with higher likelihoods of having microalbuminuria. CONCLUSIONS: Quantitative changes of the retinal vascular geometry and qualitative changes in the vessel architecture are associated with markers of renal dysfunction and damage.

Full Text

Duke Authors

Cited Authors

  • Lim, LS; Cheung, CY-L; Sabanayagam, C; Lim, SC; Tai, ES; Huang, L; Wong, TY

Published Date

  • April 26, 2013

Published In

Volume / Issue

  • 54 / 4

Start / End Page

  • 2970 - 2976

PubMed ID

  • 23572105

Pubmed Central ID

  • 23572105

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

International Standard Serial Number (ISSN)

  • 0146-0404

Digital Object Identifier (DOI)

  • 10.1167/iovs.13-11941

Language

  • eng