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Structural changes in the retinal microvasculature and renal function.

Publication ,  Journal Article
Lim, LS; Cheung, CY-L; Sabanayagam, C; Lim, SC; Tai, ES; Huang, L; Wong, TY
Published in: Invest Ophthalmol Vis Sci
April 26, 2013

PURPOSE: To evaluate the associations between chronic kidney disease (CKD) and microalbuminuria, and a comprehensive range of retinal microvascular abnormalities including traditional and new retinal vascular measures. METHODS: This was a population-based, cross-sectional study on 3280 urban Malay adults. The albumin/creatinine ratio (ACR) was calculated from spot urine samples. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine concentration. Retinal vascular caliber and geometry were quantified from retinal fundus photographs using a semiautomated computer-assisted program. Qualitative changes including focal arteriolar narrowing, arteriovenous nicking, and opacification of the arteriolar wall were assessed by trained graders. RESULTS: In multivariate analyses adjusting for age, sex, hypertension, diabetes, and smoking, narrower retinal arteriolar caliber (P = 0.008), smaller retinal vascular fractal dimensions (P = 0.014), and the presence of AV nicking and opacification (P = 0.005 and P < 0.001, respectively) were significantly associated with lower eGFR. In multivariate adjusted logistic regression analyses, none of the retinal markers was associated with CKD. A smaller fractal dimension (P < 0.001) and the presence of focal arteriolar narrowing, AV nicking and opacification were associated with higher ACR (P < 0.001, P = 0.01, and P = 0.002, respectively). Narrower retinal arterioles (P = 0.041); smaller fractal dimensions (P = 0.006); and focal arteriolar narrowing, AV nicking, and opacification (P = 0.007, P = 0.007, and P = 0.012, respectively) were associated with higher likelihoods of having microalbuminuria. CONCLUSIONS: Quantitative changes of the retinal vascular geometry and qualitative changes in the vessel architecture are associated with markers of renal dysfunction and damage.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

April 26, 2013

Volume

54

Issue

4

Start / End Page

2970 / 2976

Location

United States

Related Subject Headings

  • Retinal Vessels
  • Photography
  • Ophthalmology & Optometry
  • Multivariate Analysis
  • Middle Aged
  • Kidney Diseases
  • Humans
  • Glomerular Filtration Rate
  • Cross-Sectional Studies
  • Creatinine
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lim, L. S., Cheung, C.-L., Sabanayagam, C., Lim, S. C., Tai, E. S., Huang, L., & Wong, T. Y. (2013). Structural changes in the retinal microvasculature and renal function. Invest Ophthalmol Vis Sci, 54(4), 2970–2976. https://doi.org/10.1167/iovs.13-11941
Lim, Laurence Shen, Carol Yim-Lui Cheung, Charumathi Sabanayagam, Su Chi Lim, E Shyong Tai, Lei Huang, and Tien Yin Wong. “Structural changes in the retinal microvasculature and renal function.Invest Ophthalmol Vis Sci 54, no. 4 (April 26, 2013): 2970–76. https://doi.org/10.1167/iovs.13-11941.
Lim LS, Cheung CY-L, Sabanayagam C, Lim SC, Tai ES, Huang L, et al. Structural changes in the retinal microvasculature and renal function. Invest Ophthalmol Vis Sci. 2013 Apr 26;54(4):2970–6.
Lim, Laurence Shen, et al. “Structural changes in the retinal microvasculature and renal function.Invest Ophthalmol Vis Sci, vol. 54, no. 4, Apr. 2013, pp. 2970–76. Pubmed, doi:10.1167/iovs.13-11941.
Lim LS, Cheung CY-L, Sabanayagam C, Lim SC, Tai ES, Huang L, Wong TY. Structural changes in the retinal microvasculature and renal function. Invest Ophthalmol Vis Sci. 2013 Apr 26;54(4):2970–2976.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

April 26, 2013

Volume

54

Issue

4

Start / End Page

2970 / 2976

Location

United States

Related Subject Headings

  • Retinal Vessels
  • Photography
  • Ophthalmology & Optometry
  • Multivariate Analysis
  • Middle Aged
  • Kidney Diseases
  • Humans
  • Glomerular Filtration Rate
  • Cross-Sectional Studies
  • Creatinine