Systemic associations of dynamic retinal vessel analysis: a review of current literature.

Journal Article (Journal Article;Review)

Endothelial dysfunction is a key pathogenic mechanism of CVD. The retinal microvascular network offers a unique, non-invasive window to study endothelial function. Recently, dynamic measurement of retinal vessel caliber using flicker light stimulation has been used to evaluate potential endothelial dysfunction and other mechanisms in CVD. A variety of studies now indicate that retinal vasodilation during flicker light simulation is reduced in diabetes, hypertension, hyperlipidemia and obesity, and may be influenced by age and race/ethnicity. These data suggest that flicker light-induced retinal vasodilation may be a unique and non-invasive measure of endothelial dysfunction. This review focuses recent studies on systemic associations of flicker light-induced retinal vasodilation, and discusses the potential for future research in this area.

Full Text

Duke Authors

Cited Authors

  • Lim, M; Sasongko, MB; Ikram, MK; Lamoureux, E; Wang, JJ; Wong, TY; Cheung, CY

Published Date

  • April 2013

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 257 - 268

PubMed ID

  • 23151190

Electronic International Standard Serial Number (EISSN)

  • 1549-8719

Digital Object Identifier (DOI)

  • 10.1111/micc.12026


  • eng

Conference Location

  • United States