Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography.

Journal Article (Journal Article)

PURPOSE: To determine the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). METHODS: Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. RESULTS: The mean (±SD) age of study subjects was 52.84 ± 6.14 years, 50.1% were male, and all subjects had normal visual fields with no signs of glaucoma or glaucoma suspect. The mean overall, minimum, superior, and inferior GC-IPL thicknesses were 82.78 ± 7.01 μm, 79.67 ± 9.17 μm, 83.30 ± 7.89 μm, and 80.16 ± 8.31 μm, respectively. In multiple linear regression analysis, GC-IPL thickness was significantly associated with age (β = -0.202, P < 0.001), female sex (β = -2.367, P < 0.001), axial length (β = -1.279, P = 0.002), and mean peripapillary retinal nerve fiber layer (RNFL) thickness (β = 0.337, P < 0.001). IOP, central corneal thickness, disc area, serum glucose level, and history of diabetes mellitus had no significant influence on GC-IPL thickness. CONCLUSIONS: Thinner GC-IPL was independently associated with older age, female sex, longer axial length, and thinner RNFL thickness. These factors should be taken into account when interpreting GC-IPL thickness measurements with HD-OCT for glaucoma assessment.

Full Text

Duke Authors

Cited Authors

  • Koh, VT; Tham, Y-C; Cheung, CY; Wong, W-L; Baskaran, M; Saw, S-M; Wong, TY; Aung, T

Published Date

  • August 24, 2012

Published In

Volume / Issue

  • 53 / 9

Start / End Page

  • 5853 - 5859

PubMed ID

  • 22836772

Electronic International Standard Serial Number (EISSN)

  • 1552-5783

Digital Object Identifier (DOI)

  • 10.1167/iovs.12-10414


  • eng

Conference Location

  • United States