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Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography.

Publication ,  Journal Article
Koh, VT; Tham, Y-C; Cheung, CY; Wong, W-L; Baskaran, M; Saw, S-M; Wong, TY; Aung, T
Published in: Invest Ophthalmol Vis Sci
August 24, 2012

PURPOSE: To determine the distribution, variation, and determinants of ganglion cell-inner plexiform layer (GC-IPL) thickness in nonglaucomatous eyes measured by high-definition optical coherence tomography (HD-OCT). METHODS: Six hundred twenty-three Chinese adults aged 40 to 80 years were consecutively recruited from a population-based study. All subjects underwent a standardized interview, ophthalmic examination, and automated perimetry. HD-OCT with macular cube protocol was used to measure the GC-IPL thickness. Univariate and multiple linear regression analyses were performed to examine the relationship between GC-IPL thickness with ocular and systemic factors. RESULTS: The mean (±SD) age of study subjects was 52.84 ± 6.14 years, 50.1% were male, and all subjects had normal visual fields with no signs of glaucoma or glaucoma suspect. The mean overall, minimum, superior, and inferior GC-IPL thicknesses were 82.78 ± 7.01 μm, 79.67 ± 9.17 μm, 83.30 ± 7.89 μm, and 80.16 ± 8.31 μm, respectively. In multiple linear regression analysis, GC-IPL thickness was significantly associated with age (β = -0.202, P < 0.001), female sex (β = -2.367, P < 0.001), axial length (β = -1.279, P = 0.002), and mean peripapillary retinal nerve fiber layer (RNFL) thickness (β = 0.337, P < 0.001). IOP, central corneal thickness, disc area, serum glucose level, and history of diabetes mellitus had no significant influence on GC-IPL thickness. CONCLUSIONS: Thinner GC-IPL was independently associated with older age, female sex, longer axial length, and thinner RNFL thickness. These factors should be taken into account when interpreting GC-IPL thickness measurements with HD-OCT for glaucoma assessment.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

August 24, 2012

Volume

53

Issue

9

Start / End Page

5853 / 5859

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Ganglion Cells
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
MLA
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Koh, V. T., Tham, Y.-C., Cheung, C. Y., Wong, W.-L., Baskaran, M., Saw, S.-M., … Aung, T. (2012). Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Invest Ophthalmol Vis Sci, 53(9), 5853–5859. https://doi.org/10.1167/iovs.12-10414
Koh, Victor T., Yih-Chung Tham, Carol Y. Cheung, Wan-Ling Wong, Mani Baskaran, Seang-Mei Saw, Tien Y. Wong, and Tin Aung. “Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography.Invest Ophthalmol Vis Sci 53, no. 9 (August 24, 2012): 5853–59. https://doi.org/10.1167/iovs.12-10414.
Koh VT, Tham Y-C, Cheung CY, Wong W-L, Baskaran M, Saw S-M, et al. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Aug 24;53(9):5853–9.
Koh, Victor T., et al. “Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography.Invest Ophthalmol Vis Sci, vol. 53, no. 9, Aug. 2012, pp. 5853–59. Pubmed, doi:10.1167/iovs.12-10414.
Koh VT, Tham Y-C, Cheung CY, Wong W-L, Baskaran M, Saw S-M, Wong TY, Aung T. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Aug 24;53(9):5853–5859.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

August 24, 2012

Volume

53

Issue

9

Start / End Page

5853 / 5859

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Visual Acuity
  • Tomography, Optical Coherence
  • Retinal Ganglion Cells
  • Optic Disk
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male