The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients.

Journal Article (Journal Article)

Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r=-0.207, P=0.014). After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85, CI 1.82-105.67), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83, CI 0.89-16.48), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.

Full Text

Duke Authors

Cited Authors

  • De Silva, DA; Woon, F-P; Manzano, JJF; Liu, EY; Chang, H-M; Chen, C; Wang, JJ; Mitchell, P; Kingwell, BA; Cameron, JD; Lindley, RI; Wong, TY; Wong, M-C; behalf of the Multi-Centre Retinal Stroke Study Collaborative Group,

Published Date

  • December 2012

Published In

Volume / Issue

  • 26 / 12

Start / End Page

  • 716 - 722

PubMed ID

  • 21975690

Electronic International Standard Serial Number (EISSN)

  • 1476-5527

Digital Object Identifier (DOI)

  • 10.1038/jhh.2011.88


  • eng

Conference Location

  • England