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The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients.

Publication ,  Journal Article
De Silva, DA; Woon, F-P; Manzano, JJF; Liu, EY; Chang, H-M; Chen, C; Wang, JJ; Mitchell, P; Kingwell, BA; Cameron, JD; Lindley, RI; Wong, TY ...
Published in: J Hum Hypertens
December 2012

Large-artery stiffness is a risk factor for stroke, including cerebral small-vessel disease. Retinal microvascular changes are thought to mirror those in cerebral microvessels. We investigated the relationship between aortic stiffness and retinal microvascular changes in Asian ischemic stroke patients. We studied 145 acute ischemic stroke patients in Singapore who had aortic stiffness measurements using carotid-femoral pulse wave velocity (cPWV). Retinal photographs were assessed for retinal microvessel caliber and qualitative signs of focal arteriolar narrowing, arteriovenous nicking and enhanced arteriolar light reflex. Aortic stiffening was associated with retinal arteriolar changes. Retinal arteriolar caliber decreased with increasing cPWV (r=-0.207, P=0.014). After adjusting for age, gender, hypertension, diabetes, mean arterial pressure and small-vessel stroke subtype, patients within the highest cPWV quartile were more likely to have generalized retinal arteriolar narrowing defined as lowest caliber tertile (odds ratio (OR) 6.84, 95% confidence interval (CI) 1.45-32.30), focal arteriolar narrowing (OR 13.85, CI 1.82-105.67), arteriovenous nicking (OR 5.08, CI 1.12-23.00) and enhanced arteriolar light reflex (OR 3.83, CI 0.89-16.48), compared with those within the lowest quartile. In ischemic stroke patients, aortic stiffening is associated with retinal arteriolar luminal narrowing as well as features of retinal arteriolosclerosis.

Duke Scholars

Published In

J Hum Hypertens

DOI

EISSN

1476-5527

Publication Date

December 2012

Volume

26

Issue

12

Start / End Page

716 / 722

Location

England

Related Subject Headings

  • Vascular Stiffness
  • Stroke
  • Singapore
  • Risk Factors
  • Retrospective Studies
  • Retinal Vessels
  • Pulse Wave Analysis
  • Middle Aged
  • Microvessels
  • Microcirculation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
De Silva, D. A., Woon, F.-P., Manzano, J. J. F., Liu, E. Y., Chang, H.-M., Chen, C., … behalf of the Multi-Centre Retinal Stroke Study Collaborative Group, . (2012). The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. J Hum Hypertens, 26(12), 716–722. https://doi.org/10.1038/jhh.2011.88
De Silva, D. A., F. -. P. Woon, J. J. F. Manzano, E. Y. Liu, H. -. M. Chang, C. Chen, J. J. Wang, et al. “The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients.J Hum Hypertens 26, no. 12 (December 2012): 716–22. https://doi.org/10.1038/jhh.2011.88.
De Silva DA, Woon F-P, Manzano JJF, Liu EY, Chang H-M, Chen C, et al. The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. J Hum Hypertens. 2012 Dec;26(12):716–22.
De Silva, D. A., et al. “The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients.J Hum Hypertens, vol. 26, no. 12, Dec. 2012, pp. 716–22. Pubmed, doi:10.1038/jhh.2011.88.
De Silva DA, Woon F-P, Manzano JJF, Liu EY, Chang H-M, Chen C, Wang JJ, Mitchell P, Kingwell BA, Cameron JD, Lindley RI, Wong TY, Wong M-C, behalf of the Multi-Centre Retinal Stroke Study Collaborative Group. The relationship between aortic stiffness and changes in retinal microvessels among Asian ischemic stroke patients. J Hum Hypertens. 2012 Dec;26(12):716–722.

Published In

J Hum Hypertens

DOI

EISSN

1476-5527

Publication Date

December 2012

Volume

26

Issue

12

Start / End Page

716 / 722

Location

England

Related Subject Headings

  • Vascular Stiffness
  • Stroke
  • Singapore
  • Risk Factors
  • Retrospective Studies
  • Retinal Vessels
  • Pulse Wave Analysis
  • Middle Aged
  • Microvessels
  • Microcirculation