Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES).

Journal Article

OBJECTIVE: To describe the distribution and determinants of the optic cup to disc ratio (CDR) in Malay adults in Singapore. METHODS: This population-based, age-stratified study examined 3280 Malay people aged 40 to 80 years in Singapore. Participants underwent a standardized interview and an ocular examination. A slitlamp examination measured the vertical dimensions of the disc and cup, excluding areas of peripapillary atrophy and the Elschnig scleral ring. RESULTS: Vertical CDR was recorded for 3228 right eyes and 3237 left eyes. The mean (SD) CDR was 0.40 (0.15) in both eyes. The CDR in the right eye increased with age (P < .001) and was greater in men vs women (age-adjusted CDR, 0.42 vs 0.39; P < .001). In multiple linear regression, significant determinants of greater CDR were increasing age, male sex, higher intraocular pressure (IOP), lower diastolic blood pressure, lower body mass index, and previous cataract surgery. Of these, higher IOP was the most important determinant of the CDR. After excluding 149 persons with glaucoma, male sex, higher IOP, lower diastolic blood pressure, lower body mass index, and diabetes mellitus were significant predictors of greater CDR. CONCLUSION: Greater vertical CDR was related to male sex, higher IOP, lower diastolic blood pressure, and lower body mass index.

Full Text

Duke Authors

Cited Authors

  • Amerasinghe, N; Wong, TY; Wong, W-L; Mitchell, P; Shen, SY; Loon, S-C; Saw, S-M; Foster, PJ; Aung, T; SiMES Study Group,

Published Date

  • August 2008

Published In

Volume / Issue

  • 126 / 8

Start / End Page

  • 1101 - 1108

PubMed ID

  • 18695105

Electronic International Standard Serial Number (EISSN)

  • 1538-3601

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.126.8.1101

Language

  • eng