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Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES).

Publication ,  Journal Article
Amerasinghe, N; Wong, TY; Wong, W-L; Mitchell, P; Shen, SY; Loon, S-C; Saw, S-M; Foster, PJ; Aung, T; SiMES Study Group,
Published in: Arch Ophthalmol
August 2008

OBJECTIVE: To describe the distribution and determinants of the optic cup to disc ratio (CDR) in Malay adults in Singapore. METHODS: This population-based, age-stratified study examined 3280 Malay people aged 40 to 80 years in Singapore. Participants underwent a standardized interview and an ocular examination. A slitlamp examination measured the vertical dimensions of the disc and cup, excluding areas of peripapillary atrophy and the Elschnig scleral ring. RESULTS: Vertical CDR was recorded for 3228 right eyes and 3237 left eyes. The mean (SD) CDR was 0.40 (0.15) in both eyes. The CDR in the right eye increased with age (P < .001) and was greater in men vs women (age-adjusted CDR, 0.42 vs 0.39; P < .001). In multiple linear regression, significant determinants of greater CDR were increasing age, male sex, higher intraocular pressure (IOP), lower diastolic blood pressure, lower body mass index, and previous cataract surgery. Of these, higher IOP was the most important determinant of the CDR. After excluding 149 persons with glaucoma, male sex, higher IOP, lower diastolic blood pressure, lower body mass index, and diabetes mellitus were significant predictors of greater CDR. CONCLUSION: Greater vertical CDR was related to male sex, higher IOP, lower diastolic blood pressure, and lower body mass index.

Duke Scholars

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

August 2008

Volume

126

Issue

8

Start / End Page

1101 / 1108

Location

United States

Related Subject Headings

  • Singapore
  • Sex Factors
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Malaysia
  • Intraocular Pressure
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Amerasinghe, N., Wong, T. Y., Wong, W.-L., Mitchell, P., Shen, S. Y., Loon, S.-C., … SiMES Study Group, . (2008). Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES). Arch Ophthalmol, 126(8), 1101–1108. https://doi.org/10.1001/archopht.126.8.1101
Amerasinghe, Nishani, Tien Y. Wong, Wan-Ling Wong, Paul Mitchell, Sunny Y. Shen, Seng-Chee Loon, Seang-Mei Saw, Paul J. Foster, Tin Aung, and Tin SiMES Study Group. “Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES).Arch Ophthalmol 126, no. 8 (August 2008): 1101–8. https://doi.org/10.1001/archopht.126.8.1101.
Amerasinghe N, Wong TY, Wong W-L, Mitchell P, Shen SY, Loon S-C, et al. Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES). Arch Ophthalmol. 2008 Aug;126(8):1101–8.
Amerasinghe, Nishani, et al. “Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES).Arch Ophthalmol, vol. 126, no. 8, Aug. 2008, pp. 1101–08. Pubmed, doi:10.1001/archopht.126.8.1101.
Amerasinghe N, Wong TY, Wong W-L, Mitchell P, Shen SY, Loon S-C, Saw S-M, Foster PJ, Aung T, SiMES Study Group. Determinants of the optic cup to disc ratio in an Asian population: the Singapore Malay Eye Study (SiMES). Arch Ophthalmol. 2008 Aug;126(8):1101–1108.

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

August 2008

Volume

126

Issue

8

Start / End Page

1101 / 1108

Location

United States

Related Subject Headings

  • Singapore
  • Sex Factors
  • Optic Nerve Diseases
  • Optic Disk
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Malaysia
  • Intraocular Pressure
  • Humans