A Closed Loop Brain-machine Interface for Epilepsy Control Using Dorsal Column Electrical Stimulation.
Journal Article (Journal Article)
Although electrical neurostimulation has been proposed as an alternative treatment for drug-resistant cases of epilepsy, current procedures such as deep brain stimulation, vagus, and trigeminal nerve stimulation are effective only in a fraction of the patients. Here we demonstrate a closed loop brain-machine interface that delivers electrical stimulation to the dorsal column (DCS) of the spinal cord to suppress epileptic seizures. Rats were implanted with cortical recording microelectrodes and spinal cord stimulating electrodes, and then injected with pentylenetetrazole to induce seizures. Seizures were detected in real time from cortical local field potentials, after which DCS was applied. This method decreased seizure episode frequency by 44% and seizure duration by 38%. We argue that the therapeutic effect of DCS is related to modulation of cortical theta waves, and propose that this closed-loop interface has the potential to become an effective and semi-invasive treatment for refractory epilepsy and other neurological disorders.
Full Text
- Published version (via Digital Object Identifier)
- Pubmed Central version
- Open Access Copy from Duke
- Link to Item
Duke Authors
Cited Authors
- Pais-Vieira, M; Yadav, AP; Moreira, D; Guggenmos, D; Santos, A; Lebedev, M; Nicolelis, MAL
Published Date
- September 8, 2016
Published In
Volume / Issue
- 6 /
Start / End Page
- 32814 -
PubMed ID
- 27605389
Pubmed Central ID
- PMC5015048
Electronic International Standard Serial Number (EISSN)
- 2045-2322
Digital Object Identifier (DOI)
- 10.1038/srep32814
Language
- eng
Conference Location
- England