Soft Tissue Sarcoma, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology.

Journal Article (Journal Article)

Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for Soft Tissue Sarcoma (available at provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumor, desmoid tumors, and rhabdomyosarcoma. This manuscript discusses guiding principles for the diagnosis and staging of STS and evidence for treatment modalities that include surgery, radiation, chemoradiation, chemotherapy, and targeted therapy.

Full Text

Duke Authors

Cited Authors

  • von Mehren, M; Randall, RL; Benjamin, RS; Boles, S; Bui, MM; Conrad, EU; Ganjoo, KN; George, S; Gonzalez, RJ; Heslin, MJ; Kane, JM; Koon, H; Mayerson, J; McCarter, M; McGarry, SV; Meyer, C; O'Donnell, RJ; Pappo, AS; Paz, IB; Petersen, IA; Pfeifer, JD; Riedel, RF; Schuetze, S; Schupak, KD; Schwartz, HS; Tap, WD; Wayne, JD; Bergman, MA; Scavone, J

Published Date

  • June 2016

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 758 - 786

PubMed ID

  • 27283169

Electronic International Standard Serial Number (EISSN)

  • 1540-1413

Digital Object Identifier (DOI)

  • 10.6004/jnccn.2016.0078


  • eng

Conference Location

  • United States