Inhibition, Not Excitation, Drives Rhythmic Whisking.

Published

Journal Article

Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBötC to the vIRt. The preBötC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBötC cells. These data yield a putative circuit in which the preBötC acts as a master clock for the synchronization of vibrissa, pad, and snout movements, as well as for the bilateral synchronization of whisking.

Full Text

Duke Authors

Cited Authors

  • Deschênes, M; Takatoh, J; Kurnikova, A; Moore, JD; Demers, M; Elbaz, M; Furuta, T; Wang, F; Kleinfeld, D

Published Date

  • April 20, 2016

Published In

Volume / Issue

  • 90 / 2

Start / End Page

  • 374 - 387

PubMed ID

  • 27041498

Pubmed Central ID

  • 27041498

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2016.03.007

Language

  • eng

Conference Location

  • United States