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Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature.

Publication ,  Journal Article
Babi, M-A; Kraft, BD; Sengupta, S; Peterson, H; Orgel, R; Wegermann, Z; Lugogo, NL; Luedke, MW
Published in: SAGE Open Med Case Rep
2016

BACKGROUND: We report a novel case of a rare disease: spontaneous Creutzfeldt-Jakob disease in a patient with well-controlled HIV. We explore the relationship between spontaneous Creutzfeldt-Jakob disease and HIV. CASE REPORT: A 66-year-old man with long-standing, well-controlled HIV infection presented with 3 months of progressive, subacute neurocognitive decline. His symptoms included conceptual apraxia, apathy, memory impairment, and gait disturbance, and were initially attributed to depressive "pseudo-dementia." Unfortunately, the patient's symptoms rapidly progressed and he ultimately succumbed to his illness. Autopsy confirmed the clinical diagnosis of spontaneous Creutzfeldt-Jakob disease. DISCUSSION: This case highlights spontaneous Creutzfeldt-Jakob disease as a rare terminal illness in the setting of well-controlled chronic HIV. To our knowledge, this is the first report of a patient with chronic and previously well-controlled HIV infection dying from a prion disease. Despite the very different epidemiology and pathophysiology of HIV and spontaneous Creutzfeldt-Jakob disease, this case does raise questions of whether certain host genetic factors could predispose to both conditions, albeit currently, there is no clear causal link between HIV and spontaneous Creutzfeldt-Jakob disease.

Duke Scholars

Published In

SAGE Open Med Case Rep

DOI

ISSN

2050-313X

Publication Date

2016

Volume

4

Start / End Page

2050313X16672153

Location

England

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences
 

Citation

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Babi, M.-A., Kraft, B. D., Sengupta, S., Peterson, H., Orgel, R., Wegermann, Z., … Luedke, M. W. (2016). Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature. SAGE Open Med Case Rep, 4, 2050313X16672153. https://doi.org/10.1177/2050313X16672153
Babi, M-Alain, Bryan D. Kraft, Sweta Sengupta, Haley Peterson, Ryan Orgel, Zachary Wegermann, Njira L. Lugogo, and Matthew W. Luedke. “Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature.SAGE Open Med Case Rep 4 (2016): 2050313X16672153. https://doi.org/10.1177/2050313X16672153.
Babi M-A, Kraft BD, Sengupta S, Peterson H, Orgel R, Wegermann Z, et al. Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature. SAGE Open Med Case Rep. 2016;4:2050313X16672153.
Babi, M. Alain, et al. “Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature.SAGE Open Med Case Rep, vol. 4, 2016, p. 2050313X16672153. Pubmed, doi:10.1177/2050313X16672153.
Babi M-A, Kraft BD, Sengupta S, Peterson H, Orgel R, Wegermann Z, Lugogo NL, Luedke MW. Related or not? Development of spontaneous Creutzfeldt-Jakob disease in a patient with chronic, well-controlled HIV: A case report and review of the literature. SAGE Open Med Case Rep. 2016;4:2050313X16672153.
Journal cover image

Published In

SAGE Open Med Case Rep

DOI

ISSN

2050-313X

Publication Date

2016

Volume

4

Start / End Page

2050313X16672153

Location

England

Related Subject Headings

  • 42 Health sciences
  • 32 Biomedical and clinical sciences