Cellular plasticity: 1712 to the present day.

Journal Article (Journal Article;Review)

Cell identity is a fundamental feature of cells. Tissues are often organized into cellular hierarchies characterized by progressive differentiation and developmental commitment. However, it is been historically evident that the cells of many organisms of various phyla, especially in the context of injury, exhibit remarkable plasticity in terms of their ability to convert into other cell types. Recent modern studies, using genetic lineage tracing, have demonstrated that many mature functional cells retain a potential to undergo lineage reversion (dedifferentiation) or to convert into cells of other more distant lineages (transdifferentiation) following injury. Similarly, mimicking progenitor cell transdetermination, stem cells can interconvert. These forms of plasticity may be essential for organismal survival, and are likely part and parcel of regeneration.

Full Text

Duke Authors

Cited Authors

  • Tata, PR; Rajagopal, J

Published Date

  • December 2016

Published In

Volume / Issue

  • 43 /

Start / End Page

  • 46 - 54

PubMed ID

  • 27485353

Pubmed Central ID

  • PMC5154913

Electronic International Standard Serial Number (EISSN)

  • 1879-0410

Digital Object Identifier (DOI)

  • 10.1016/j.ceb.2016.07.005


  • eng

Conference Location

  • England