Purushothama Rao Tata
Assistant Professor of Cell Biology
Lung regeneration
Lung stem cells
Cell plasticity
Organoid models
Lung Fibrosis
Single Cell Biology
Lung stem cells
Cell plasticity
Organoid models
Lung Fibrosis
Single Cell Biology
Current Appointments & Affiliations
- Assistant Professor of Cell Biology, Cell Biology, Basic Science Departments 2016
- Assistant Professor in Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2021
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2016
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- Background
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Education, Training, & Certifications
- Ph.D., University of Ulm (Germany) 2011
- Recognition
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In the News
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JUL 20, 2022 -
NOV 19, 2020 NIH-Directors blog -
OCT 22, 2020 -
MAY 11, 2020 www.hhmi.org -
MAR 26, 2018 -
OCT 2, 2016
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Awards & Honors
- Rising Star Award. International Society for Regenerative Biology. September 2022
- Whitehead Scholar Award. Duke University School of Medicine. September 2016
- NIH K99-Pathways to Independence Award. National Institutes of Health. September 15, 2015
- The Fund for Medical Discovery (FMD) Research Award. Massachusetts General Hospital. January 30, 2014
- Expertise
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Subject Headings
- Research
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Selected Grants
- Ferroptosis and Ferroptotic Stress in Maladaptive Renal Repair - R01 awarded by National Institutes of Health 2023 - 2028
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Cellular crosstalk and molecular mechanisms in the initiation and progression of pulmonary fibrosis awarded by National Institutes of Health 2022 - 2026
- Pulmonary cell fate and lung repair in rodent and porcine models of chlorine and phosgene inhalation injuries awarded by National Institutes of Health 2022 - 2025
- R01: Targeting Renal Tubular Epithelial Progenitors in AKI to CKD transition awarded by National Institutes of Health 2020 - 2025
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Perpetual Organ Preservation and Rehabilitation (POPR) awarded by National Institutes of Health 2022 - 2024
- Mapping the pediatric inhalation interface: nose mouth and airways awarded by University of North Carolina - Chapel Hill 2021 - 2024
- Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma awarded by National Institutes of Health 2020 - 2024
- Molecular control of a novel transitional cell state in alveolar regeneration awarded by National Institutes of Health 2020 - 2024
- Mechanisms of submucosal gland cell mediated airway regeneration awarded by National Institutes of Health 2019 - 2024
- Rapidly Emerging Antiviral Drug Discovery Initiative (READDI) awarded by University of North Carolina - Chapel Hill 2022 - 2024
- Targeting ABL kinases to regulate epithelial cell plasticity and regeneration following injury awarded by National Institutes of Health 2020 - 2024
- Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO) awarded by Defense Advanced Research Projects Agency 2019 - 2024
- Genome-wide loss of function screens to identify therapeutic targets in pulmonary fibrosis awarded by ONO PHARMACEUTICAL CO., LTD. 2021 - 2023
- Control of glycome structure and function through galactose epimerase awarded by G. Harold & Leila Y. Mathers Foundation 2020 - 2023
- SOX9 Expression Identifies A Novel Alveolar Stem Cell Population awarded by National Institutes of Health 2018 - 2022
- Human Lung Cell Atlas 1.0 - Year 4 awarded by Northwestern University 2019 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Systematic identification of AEC2 cell niche components and the conversion of basal stem cells into AEC2 cells ex vivo awarded by United Therapeutics Corporation 2017 - 2021
- Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
- Image-Seq: A high-density microfluidic trap array for single cell transcriptome analysis coupled with image based phenotyping awarded by National Institutes of Health 2018 - 2020
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- To define the role of Sox9 and Sox9+ Cells in Alveolar Homeostasis and Regeneration awarded by National Institutes of Health 2017 - 2019
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External Relationships
- Cellarity Inc.
- Genentech, Inc (Roche Holding)
- Glauconix Biosciences
- Herbert Schiller lab, Helmholtz Zentrum Munchen
- Iolux Inc.
- Springer Nature Publishing Company
- Surrozen Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Apostolou, Effie, Helen Blau, Kenneth Chien, Madeline A. Lancaster, Purushothama Rao Tata, Eirini Trompouki, Fiona M. Watt, Yi Arial Zeng, and Magdalena Zernicka-Goetz. “Progress and challenges in stem cell biology.” Nat Cell Biol 25, no. 2 (February 2023): 203–6. https://doi.org/10.1038/s41556-023-01087-y.Full Text Link to Item
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Ide, Shintaro, Kana Ide, Koki Abe, Yoshihiko Kobayashi, Hiroki Kitai, Jennifer McKey, Sarah A. Strausser, et al. “Sex differences in resilience to ferroptosis underlie sexual dimorphism in kidney injury and repair.” Cell Rep 41, no. 6 (November 8, 2022): 111610. https://doi.org/10.1016/j.celrep.2022.111610.Full Text Link to Item
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Yaron, Tomer M., Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, et al. “Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.” Sci Signal 15, no. 757 (October 25, 2022): eabm0808. https://doi.org/10.1126/scisignal.abm0808.Full Text Link to Item
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Konkimalla, Arvind, Satoshi Konishi, Yoshihiko Kobayashi, Preetish Kadur Lakshminarasimha Murthy, Lauren Macadlo, Ananya Mukherjee, Zachary Elmore, et al. “Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration.” Iscience 25, no. 10 (October 21, 2022): 105114. https://doi.org/10.1016/j.isci.2022.105114.Full Text Link to Item
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Konkimalla, Arvind, Aleksandra Tata, and Purushothama Rao Tata. “Lung Regeneration: Cells, Models, and Mechanisms.” Cold Spring Harb Perspect Biol 14, no. 10 (October 3, 2022). https://doi.org/10.1101/cshperspect.a040873.Full Text Link to Item
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Caetano, A. J., A. J. Human Cell Atlas Oral and Craniofacial Bionetwork, I. Sequeira, and K. M. Byrd. “A Roadmap for the Human Oral and Craniofacial Cell Atlas.” J Dent Res 101, no. 11 (October 2022): 1274–88. https://doi.org/10.1177/00220345221110768.Full Text Link to Item
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DeBenedittis, Paige, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, et al. “Coupled myovascular expansion directs cardiac growth and regeneration.” Development 149, no. 18 (September 15, 2022). https://doi.org/10.1242/dev.200654.Full Text Link to Item
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Konishi, Satoshi, Aleksandra Tata, and Purushothama Rao Tata. “Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures.” Star Protoc 3, no. 2 (June 17, 2022): 101447. https://doi.org/10.1016/j.xpro.2022.101447.Full Text Open Access Copy Link to Item
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Leinroth, Abigail P., Anthony J. Mirando, Douglas Rouse, Yoshihiko Kobayahsi, Purushothama Rao Tata, Helen E. Rueckert, Yihan Liao, Jason T. Long, Joe V. Chakkalakal, and Matthew J. Hilton. “Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations.” Cell Rep 39, no. 6 (May 10, 2022): 110785. https://doi.org/10.1016/j.celrep.2022.110785.Full Text Link to Item
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El Haddad, L., E. Lai, P. Murthy, P. R. Tata, and M. K. ElMallah. “GAA Deficiency Disrupts Distal Airway Cells in Pompe Disease.” Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 36 (May 1, 2022). https://doi.org/10.1096/fasebj.2022.36.S1.L7829.Full Text
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Kadur Lakshminarasimha Murthy, Preetish, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Lauren Macadlo, Kenichi Okuda, Ansley S. Conchola, et al. “Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.” Nature 604, no. 7904 (April 2022): 111–19. https://doi.org/10.1038/s41586-022-04541-3.Full Text Link to Item
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Kadur Lakshminarasimha Murthy, Preetish, Rui Xi, Diana Arguijo, Jeffrey I. Everitt, Dewran D. Kocak, Yoshihiko Kobayashi, Aline Bozec, et al. “Epigenetic basis of oncogenic-Kras-mediated epithelial-cellular proliferation and plasticity.” Dev Cell 57, no. 3 (February 7, 2022): 310-328.e9. https://doi.org/10.1016/j.devcel.2022.01.006.Full Text Link to Item
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Kumar, Vardhman, Sajeesh Kumar Madhurakkat Perikamana, Aleksandra Tata, Jiaul Hoque, Anna Gilpin, Purushothama Rao Tata, and Shyni Varghese. “An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics.” Front Bioeng Biotechnol 10 (2022): 848699. https://doi.org/10.3389/fbioe.2022.848699.Full Text Link to Item
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Wang, Lihua, Ergang Wang, Jorge Prado Balcazar, Zhenzhen Wu, Kun Xiang, Yi Wang, Qiang Huang, et al. “Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis.” Adv Sci (Weinh) 8, no. 19 (October 2021): e2004673. https://doi.org/10.1002/advs.202004673.Full Text Link to Item
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Ide, Shintaro, Yoshihiko Kobayashi, Kana Ide, Sarah A. Strausser, Koki Abe, Savannah Herbek, Lori L. O’Brien, et al. “Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair.” Elife 10 (July 19, 2021). https://doi.org/10.7554/eLife.68603.Full Text Open Access Copy Link to Item
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Tata, Aleksandra, Ryan D. Chow, and Purushothama Rao Tata. “Epithelial cell plasticity: breaking boundaries and changing landscapes.” Embo Rep 22, no. 7 (July 5, 2021): e51921. https://doi.org/10.15252/embr.202051921.Full Text Link to Item
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Delorey, Toni M., Carly G. K. Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Åsa Segerstolpe, Domenic Abbondanza, et al. “COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets.” Nature 595, no. 7865 (July 2021): 107–13. https://doi.org/10.1038/s41586-021-03570-8.Full Text Link to Item
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Okuda, Kenichi, Hong Dang, Yoshihiko Kobayashi, Gianni Carraro, Satoko Nakano, Gang Chen, Takafumi Kato, et al. “Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia.” Am J Respir Crit Care Med 203, no. 10 (May 15, 2021): 1275–89. https://doi.org/10.1164/rccm.202008-3198OC.Full Text Link to Item
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Muus, Christoph, Malte D. Luecken, Gökcen Eraslan, Lisa Sikkema, Avinash Waghray, Graham Heimberg, Yoshihiko Kobayashi, et al. “Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics.” Nat Med 27, no. 3 (March 2021): 546–59. https://doi.org/10.1038/s41591-020-01227-z.Full Text Link to Item
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Delorey, Toni M., Carly G. K. Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Asa Segerstolpe, Domenic Abbondanza, et al. “A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2.” Biorxiv, February 25, 2021. https://doi.org/10.1101/2021.02.25.430130.Full Text Link to Item
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DeBenedittis, Paige, Anish Karpurapu, Albert Henry, Michael C. Thomas, Timothy J. McCord, Kyla Brezitski, Anil Prasad, et al. “Coupled myovascular expansion directs cardiac growth and regeneration,” January 21, 2021. https://doi.org/10.1101/2021.01.20.425322.Full Text
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Ide, Shintaro, Yoshihiko Kobayashi, Kana Ide, Sarah Strausser, Savannah Herbek, Lori O’Brien, Steven Crowley, et al. “Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair,” 2021. https://doi.org/10.1101/2021.03.23.436661.Full Text
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Moiseenko, Alena, Ana Ivonne Vazquez-Armendariz, Vahid Kheirollahi, Xuran Chu, Aleksandra Tata, Stefano Rivetti, Stefan Günther, et al. “Identification of a Repair-Supportive Mesenchymal Cell Population during Airway Epithelial Regeneration.” Cell Rep 33, no. 12 (December 22, 2020): 108549. https://doi.org/10.1016/j.celrep.2020.108549.Full Text Link to Item
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Yaron, Tomer M., Brook E. Heaton, Tyler M. Levy, Jared L. Johnson, Tristan X. Jordan, Benjamin M. Cohen, Alexander Kerelsky, et al. “The FDA-approved drug Alectinib compromises SARS-CoV-2 nucleocapsid phosphorylation and inhibits viral infection in vitro.” Biorxiv, December 16, 2020. https://doi.org/10.1101/2020.08.14.251207.Full Text Link to Item
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Bernardes, Joana P., Neha Mishra, Florian Tran, Thomas Bahmer, Lena Best, Johanna I. Blase, Dora Bordoni, et al. “Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19.” Immunity 53, no. 6 (December 15, 2020): 1296-1314.e9. https://doi.org/10.1016/j.immuni.2020.11.017.Full Text Link to Item
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Katsura, Hiroaki, Vishwaraj Sontake, Aleksandra Tata, Yoshihiko Kobayashi, Caitlin E. Edwards, Brook E. Heaton, Arvind Konkimalla, et al. “Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.” Cell Stem Cell 27, no. 6 (December 3, 2020): 890-904.e8. https://doi.org/10.1016/j.stem.2020.10.005.Full Text Open Access Copy Link to Item
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Sapoznik, Etai, Bo-Jui Chang, Jaewon Huh, Robert J. Ju, Evgenia V. Azarova, Theresa Pohlkamp, Erik S. Welf, et al. “A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics.” Elife 9 (November 12, 2020). https://doi.org/10.7554/eLife.57681.Full Text Link to Item
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Sontake, Vishwaraj, and Purushothama Rao Tata. “BALO: a "mini lung" model to study cell-cell interactions.” Embo J 39, no. 21 (November 2, 2020): e106697. https://doi.org/10.15252/embj.2020106697.Full Text Link to Item
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Kobayashi, Yoshihiko, Aleksandra Tata, Arvind Konkimalla, Hiroaki Katsura, Rebecca F. Lee, Jianhong Ou, Nicholas E. Banovich, Jonathan A. Kropski, and Purushothama Rao Tata. “Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis.” Nat Cell Biol 22, no. 8 (August 2020): 934–46. https://doi.org/10.1038/s41556-020-0542-8.Full Text Link to Item
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Hou, Yixuan J., Kenichi Okuda, Caitlin E. Edwards, David R. Martinez, Takanori Asakura, Kenneth H. Dinnon, Takafumi Kato, et al. “SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.” Cell 182, no. 2 (July 23, 2020): 429-446.e14. https://doi.org/10.1016/j.cell.2020.05.042.Full Text Link to Item
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Ziegler, Carly G. K., Samuel J. Allon, Sarah K. Nyquist, Ian M. Mbano, Vincent N. Miao, Constantine N. Tzouanas, Yuming Cao, et al. “SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.” Cell 181, no. 5 (May 28, 2020): 1016-1035.e19. https://doi.org/10.1016/j.cell.2020.04.035.Full Text Link to Item
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Sungnak, Waradon, Ni Huang, Christophe Bécavin, Marijn Berg, Rachel Queen, Monika Litvinukova, Carlos Talavera-López, et al. “SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes.” Nat Med 26, no. 5 (May 2020): 681–87. https://doi.org/10.1038/s41591-020-0868-6.Full Text Link to Item
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Uezu, Akiyoshi, Erin Hisey, Yoshihiko Kobayashi, Yudong Gao, Tyler Wa Bradshaw, Patrick Devlin, Ramona Rodriguiz, Purushothama Rao Tata, and Scott Soderling. “Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.” Elife 8 (December 12, 2019). https://doi.org/10.7554/eLife.50712.Full Text Link to Item
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Hogan, Brigid, and Purushothama Rao Tata. “Cellular organization and biology of the respiratory system.” Nat Cell Biol, July 25, 2019. https://doi.org/10.1038/s41556-019-0357-7.Full Text Open Access Copy Link to Item
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Katsura, Hiroaki, Yoshihiko Kobayashi, Purushothama Rao Tata, and Brigid L. M. Hogan. “IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration.” Stem Cell Reports 12, no. 4 (April 9, 2019): 657–66. https://doi.org/10.1016/j.stemcr.2019.02.013.Full Text Link to Item
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Khatri, Aaditya, Bryan D. Kraft, Purushothama Rao Tata, Scott H. Randell, Claude A. Piantadosi, and Ann Marie Pendergast. “ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia.” Proc Natl Acad Sci U S A 116, no. 5 (January 29, 2019): 1603–12. https://doi.org/10.1073/pnas.1816030116.Full Text Link to Item
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Kobayashi, Yoshihiko, Aleksandra Tata, Arvind Konkimalla, Hiroaki Katsura, Rebecca Lee, Jianhong Ou, Nicholas Banovich, Jonathan Kropski, and Purushothama Rao Tata. “Persistence of a novel regeneration-associated transitional cell state in pulmonary fibrosis,” 2019. https://doi.org/10.1101/855155.Full Text
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Montoro, Daniel T., Adam L. Haber, Moshe Biton, Vladimir Vinarsky, Brian Lin, Susan E. Birket, Feng Yuan, et al. “A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.” Nature 560, no. 7718 (August 2018): 319–24. https://doi.org/10.1038/s41586-018-0393-7.Full Text Link to Item
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Kobayashi, Yoshihiko, and Purushothama Rao Tata. “Pulmonary Neuroendocrine Cells: Sensors and Sentinels of the Lung.” Dev Cell 45, no. 4 (May 21, 2018): 425–26. https://doi.org/10.1016/j.devcel.2018.05.009.Full Text Link to Item
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Tata, Aleksandra, Yoshihiko Kobayashi, Ryan D. Chow, Jasmine Tran, Avani Desai, Abdull J. Massri, Timothy J. McCord, Michael Dee Gunn, and Purushothama Rao Tata. “Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury.” Cell Stem Cell 22, no. 5 (May 3, 2018): 668-683.e6. https://doi.org/10.1016/j.stem.2018.03.018.Full Text Link to Item
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Taylor, Martin S., Raghu R. Chivukula, Laura C. Myers, William R. Jeck, Avinash Waghray, Purushothama R. Tata, Martin K. Selig, et al. “A Conserved Distal Lung Regenerative Pathway in Acute Lung Injury.” Am J Pathol 188, no. 5 (May 2018): 1149–60. https://doi.org/10.1016/j.ajpath.2018.01.021.Full Text Link to Item
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Tata, Purushothama Rao, Ryan D. Chow, Srinivas Vinod Saladi, Aleksandra Tata, Arvind Konkimalla, Anne Bara, Daniel Montoro, et al. “Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity.” Dev Cell 44, no. 6 (March 26, 2018): 679-693.e5. https://doi.org/10.1016/j.devcel.2018.02.024.Full Text Link to Item
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Taylor, Martin S., Raghu R. Chivukula, Laura C. Myers, William R. Jeck, Purushothama R. Tata, Walter J. O’Donnell, Carol F. Farver, B Taylor Thompson, Jayaraj Rajagopal, and Richard L. Kradin. “Delayed Alveolar Epithelialization: A Distinct Pathology in Diffuse Acute Lung Injury.” Am J Respir Crit Care Med 197, no. 4 (February 15, 2018): 522–24. https://doi.org/10.1164/rccm.201706-1094LE.Full Text Link to Item
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Konkimalla, Arvind, and Purushothama Rao Tata. “Plasticity in Olfactory Epithelium: Is It a Sniffer or Shape Shifter?” Cell Stem Cell 21, no. 6 (December 7, 2017): 707–8. https://doi.org/10.1016/j.stem.2017.11.014.Full Text Link to Item
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Hempel, Annemarie, Susanne J. Kühl, Melanie Rothe, Purushothama Rao Tata, Ioan Ovidiu Sirbu, Seppo J. Vainio, and Michael Kühl. “The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis.” Dev Biol 424, no. 1 (April 1, 2017): 28–39. https://doi.org/10.1016/j.ydbio.2017.02.014.Full Text Open Access Copy Link to Item
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Tata, Purushothama Rao, and Jayaraj Rajagopal. “Plasticity in the lung: making and breaking cell identity.” Development 144, no. 5 (March 1, 2017): 755–66. https://doi.org/10.1242/dev.143784.Full Text Open Access Copy Link to Item
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Saladi, Srinivas Vinod, Kenneth Ross, Mihriban Karaayvaz, Purushothama R. Tata, Hongmei Mou, Jayaraj Rajagopal, Sridhar Ramaswamy, and Leif W. Ellisen. “ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis.” Cancer Cell 31, no. 1 (January 9, 2017): 35–49. https://doi.org/10.1016/j.ccell.2016.12.001.Full Text Link to Item
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Tata, Purushothama Rao, and Jayaraj Rajagopal. “Cellular plasticity: 1712 to the present day.” Curr Opin Cell Biol 43 (December 2016): 46–54. https://doi.org/10.1016/j.ceb.2016.07.005.Full Text Link to Item
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Tata, Purushothama Rao, and Jayaraj Rajagopal. “Regulatory Circuits and Bi-directional Signaling between Stem Cells and Their Progeny.” Cell Stem Cell 19, no. 6 (December 1, 2016): 686–89. https://doi.org/10.1016/j.stem.2016.11.009.Full Text Link to Item
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Mou, Hongmei, Vladimir Vinarsky, Purushothama Rao Tata, Karissa Brazauskas, Soon H. Choi, Adrianne K. Crooke, Bing Zhang, et al. “Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells.” Cell Stem Cell 19, no. 2 (August 4, 2016): 217–31. https://doi.org/10.1016/j.stem.2016.05.012.Full Text Link to Item
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Pardo-Saganta, Ana, Purushothama Rao Tata, Brandon M. Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal. “Parent stem cells can serve as niches for their daughter cells.” Nature 523, no. 7562 (July 30, 2015): 597–601. https://doi.org/10.1038/nature14553.Full Text Link to Item
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Pardo-Saganta, Ana, Brandon M. Law, Purushothama Rao Tata, Jorge Villoria, Borja Saez, Hongmei Mou, Rui Zhao, and Jayaraj Rajagopal. “Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations.” Cell Stem Cell 16, no. 2 (February 5, 2015): 184–97. https://doi.org/10.1016/j.stem.2015.01.002.Full Text Link to Item
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Weidgang, Clair E., Ronan Russell, Purushothama R. Tata, Susanne J. Kühl, Anett Illing, Martin Müller, Qiong Lin, et al. “TBX3 Directs Cell-Fate Decision toward Mesendoderm.” Stem Cell Reports 2, no. 5 (May 6, 2014): 747. https://doi.org/10.1016/j.stemcr.2014.04.011.Full Text Link to Item
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Tata, Purushothama Rao, Ana Pardo-Saganta, Mythili Prabhu, Vladimir Vinarsky, Brandon M. Law, Benjamin A. Fontaine, Andrew M. Tager, and Jayaraj Rajagopal. “Airway-specific inducible transgene expression using aerosolized doxycycline.” Am J Respir Cell Mol Biol 49, no. 6 (December 2013): 1048–56. https://doi.org/10.1165/rcmb.2012-0412OC.Full Text Link to Item
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Tata, Purushothama Rao, Hongmei Mou, Ana Pardo-Saganta, Rui Zhao, Mythili Prabhu, Brandon M. Law, Vladimir Vinarsky, et al. “Dedifferentiation of committed epithelial cells into stem cells in vivo.” Nature 503, no. 7475 (November 14, 2013): 218–23. https://doi.org/10.1038/nature12777.Full Text Link to Item
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Watanabe, Hideo, Joshua M. Francis, Michele S. Woo, Banafsheh Etemad, Wenchu Lin, Daniel F. Fries, Shouyong Peng, et al. “Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.” Genes Dev 27, no. 2 (January 15, 2013): 197–210. https://doi.org/10.1101/gad.203208.112.Full Text Link to Item
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Weidgang, Clair E., Ronan Russell, Purushothama R. Tata, Susanne J. Kühl, Anett Illing, Martin Müller, Qiong Lin, et al. “TBX3 Directs Cell-Fate Decision toward Mesendoderm.” Stem Cell Reports 1, no. 3 (2013): 248–65. https://doi.org/10.1016/j.stemcr.2013.08.002.Full Text Link to Item
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Tata, Purushothama R., Nageswara R. Tata, Michael Kühl, and Ioan O. Sirbu. “Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC.” Nucleic Acids Res 39, no. 9 (May 2011): 3574–81. https://doi.org/10.1093/nar/gkq1344.Full Text Link to Item
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Rao, Tata Purushothama, and Michael Kühl. “An updated overview on Wnt signaling pathways: a prelude for more.” Circ Res 106, no. 12 (June 25, 2010): 1798–1806. https://doi.org/10.1161/CIRCRESAHA.110.219840.Full Text Open Access Copy Link to Item
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Conference Papers
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Brown, Peter, Rory Kruithoff, Lei Zhou, Yoshihiko Kobayashi, Purushothama Rao Tata, Alfred Millet-Sikking, Andrew G. York, Kevin M. Dean, Reto P. Fiolka, and Douglas P. Shepherd. “Versatile, High-Resolution, and Large Field-of-View Single-Molecule Imaging by Oblique Plane Microscopy.” In Biophysical Journal, 120:179A-179A, 2021.Link to Item
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Ellisen, Leif, Purushothama Rao Tata, Rui Zhao, Jayaraj Rajagopal, and Srinivas Vinod Saladi. “YAP1/Hippo pathway and SWI/SNF as critical players in squamous cancers and normal development.” In Molecular Cancer Research, 18:61–61, 2020.Link to Item
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Saladi, SrinivasVinod, Robert Morris, Kenneth Ross, mihriban Karaayvaz, Purushothama Rao Tata, hongmei mou, Jayaraj Rajagopal, Michael Lawrence, and Leif Ellisen. “Abstract LB-103: Defining oncogenic SWI/SNF complex mediated immune reprogramming in squamous cell carcinoma.” In Cancer Research, Vol. 79. American Association for Cancer Research (AACR), 2019. https://doi.org/10.1158/1538-7445.am2019-lb-103.Full Text
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Preprints
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Tighe, Robert M., Anastasiya Birukova, Yuryi Malakhau, Yoshihiko Kobayashi, Aaron T. Vose, Vidya Chandramohan, Jaime M. Cyphert-Daly, et al. “Allergic Asthma Responses Are Dependent on Macrophage Ontogeny.,” February 16, 2023. https://doi.org/10.1101/2023.02.16.528861.Full Text Link to Item
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- Teaching & Mentoring
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Recent Courses
- CELLBIO 493: Research Independent Study 2023
- CELLBIO 730: Stem Cell Course 2023
- CMB 710E: Cell & Molecular Biology Module V 2023
- DSCB 720: Stem Cell Course 2023
- MOLCAN 730: Stem Cell Course 2023
- PHARM 730: Stem Cell Course 2023
- CELLBIO 493: Research Independent Study 2022
- CELLBIO 730: Stem Cell Course 2022
- CMB 710D: Cell & Molecular Biology Module IV 2022
- MOLCAN 730: Stem Cell Course 2022
- PHARM 730: Stem Cell Course 2022
- CELLBIO 493: Research Independent Study 2021
- CMB 710D: Cell & Molecular Biology Module IV 2021
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