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Parent stem cells can serve as niches for their daughter cells.

Publication ,  Journal Article
Pardo-Saganta, A; Tata, PR; Law, BM; Saez, B; Chow, RD-W; Prabhu, M; Gridley, T; Rajagopal, J
Published in: Nature
July 30, 2015

Stem cells integrate inputs from multiple sources. Stem cell niches provide signals that promote stem cell maintenance, while differentiated daughter cells are known to provide feedback signals to regulate stem cell replication and differentiation. Recently, stem cells have been shown to regulate themselves using an autocrine mechanism. The existence of a 'stem cell niche' was first postulated by Schofield in 1978 to define local environments necessary for the maintenance of haematopoietic stem cells. Since then, an increasing body of work has focused on defining stem cell niches. Yet little is known about how progenitor cell and differentiated cell numbers and proportions are maintained. In the airway epithelium, basal cells function as stem/progenitor cells that can both self-renew and produce differentiated secretory cells and ciliated cells. Secretory cells also act as transit-amplifying cells that eventually differentiate into post-mitotic ciliated cells . Here we describe a mode of cell regulation in which adult mammalian stem/progenitor cells relay a forward signal to their own progeny. Surprisingly, this forward signal is shown to be necessary for daughter cell maintenance. Using a combination of cell ablation, lineage tracing and signalling pathway modulation, we show that airway basal stem/progenitor cells continuously supply a Notch ligand to their daughter secretory cells. Without these forward signals, the secretory progenitor cell pool fails to be maintained and secretory cells execute a terminal differentiation program and convert into ciliated cells. Thus, a parent stem/progenitor cell can serve as a functional daughter cell niche.

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Published In

Nature

DOI

EISSN

1476-4687

Publication Date

July 30, 2015

Volume

523

Issue

7562

Start / End Page

597 / 601

Location

England

Related Subject Headings

  • Trachea
  • Stem Cells
  • Stem Cell Niche
  • Signal Transduction
  • Receptor, Notch2
  • Mice
  • Membrane Proteins
  • Male
  • Jagged-2 Protein
  • General Science & Technology
 

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Pardo-Saganta, A., Tata, P. R., Law, B. M., Saez, B., Chow, R.-W., Prabhu, M., … Rajagopal, J. (2015). Parent stem cells can serve as niches for their daughter cells. Nature, 523(7562), 597–601. https://doi.org/10.1038/nature14553
Pardo-Saganta, Ana, Purushothama Rao Tata, Brandon M. Law, Borja Saez, Ryan Dz-Wei Chow, Mythili Prabhu, Thomas Gridley, and Jayaraj Rajagopal. “Parent stem cells can serve as niches for their daughter cells.Nature 523, no. 7562 (July 30, 2015): 597–601. https://doi.org/10.1038/nature14553.
Pardo-Saganta A, Tata PR, Law BM, Saez B, Chow RD-W, Prabhu M, et al. Parent stem cells can serve as niches for their daughter cells. Nature. 2015 Jul 30;523(7562):597–601.
Pardo-Saganta, Ana, et al. “Parent stem cells can serve as niches for their daughter cells.Nature, vol. 523, no. 7562, July 2015, pp. 597–601. Pubmed, doi:10.1038/nature14553.
Pardo-Saganta A, Tata PR, Law BM, Saez B, Chow RD-W, Prabhu M, Gridley T, Rajagopal J. Parent stem cells can serve as niches for their daughter cells. Nature. 2015 Jul 30;523(7562):597–601.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

Publication Date

July 30, 2015

Volume

523

Issue

7562

Start / End Page

597 / 601

Location

England

Related Subject Headings

  • Trachea
  • Stem Cells
  • Stem Cell Niche
  • Signal Transduction
  • Receptor, Notch2
  • Mice
  • Membrane Proteins
  • Male
  • Jagged-2 Protein
  • General Science & Technology