Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.
Journal Article (Journal Article)
This work was designed to observe the effects of nociceptin(13-17), one of the main metabolites of nociceptin (also termed orphanin FQ), in pain modulation at supraspinal level in mice. Intracerebroventricular (i.c.v.) administration of nociceptin/orphanin FQ(13-17) (N/OFQ(13-17)) (5, 0.5, 0.05, 0.005 nmol/mouse) dose-dependently induced potent hyperalgesic effects in the 48 degrees C warm-water tail-flick test in mice. I.c.v. pretreatment with N/OFQ(13-17) (5, 0.5, 0.05 nmol/mouse) potentiated the analgesic effects induced by morphine (i.p., 2 mg/kg) and reversed the hyperalgesic effects induced by N/OFQ (i.c.v., 5 nmol/mouse). The hyperalgesic effects induced by N/OFQ(13-17) could not be antagonized by [Nphe((1))]N/OFQ(1-13)NH((2)) or naloxone. These findings suggest that N/OFQ(13-17) may play important roles in pain modulation at supraspinal level in mice and elicits these effects through a novel mechanism independent of the N/OFQ receptor and the mu, delta and kappa opioid receptors.
Full Text
Duke Authors
Cited Authors
- Chen, L-X; Wang, Z-Z; Wu, H; Fang, Q; Chen, Y; Wang, R
Published Date
- October 11, 2002
Published In
Volume / Issue
- 331 / 2
Start / End Page
- 95 - 98
PubMed ID
- 12361849
International Standard Serial Number (ISSN)
- 0304-3940
Digital Object Identifier (DOI)
- 10.1016/s0304-3940(02)00844-3
Language
- eng
Conference Location
- Ireland