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Pain regulation by non-neuronal cells and inflammation.

Publication ,  Journal Article
Ji, R-R; Chamessian, A; Zhang, Y-Q
Published in: Science
November 4, 2016

Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis, nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a local inflammation in the peripheral or central nervous system. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial cells, keratinocytes, cancer cells, and stem cells play active roles in the pathogenesis and resolution of pain. We review how non-neuronal cells interact with nociceptive neurons by secreting neuroactive signaling molecules that modulate pain. Recent studies also suggest that bacterial infections regulate pain through direct actions on sensory neurons, and specific receptors are present in nociceptors to detect danger signals from infections. We also discuss new therapeutic strategies to control neuroinflammation for the prevention and treatment of chronic pain.

Duke Scholars

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

November 4, 2016

Volume

354

Issue

6312

Start / End Page

572 / 577

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • T-Lymphocytes
  • Spinal Cord
  • Rats
  • Pain
  • Nociceptors
  • Neuroglia
  • Neuritis
  • Neoplasms
  • Monocytes
 

Citation

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Ji, R.-R., Chamessian, A., & Zhang, Y.-Q. (2016). Pain regulation by non-neuronal cells and inflammation. Science, 354(6312), 572–577. https://doi.org/10.1126/science.aaf8924
Ji, Ru-Rong, Alexander Chamessian, and Yu-Qiu Zhang. “Pain regulation by non-neuronal cells and inflammation.Science 354, no. 6312 (November 4, 2016): 572–77. https://doi.org/10.1126/science.aaf8924.
Ji R-R, Chamessian A, Zhang Y-Q. Pain regulation by non-neuronal cells and inflammation. Science. 2016 Nov 4;354(6312):572–7.
Ji, Ru-Rong, et al. “Pain regulation by non-neuronal cells and inflammation.Science, vol. 354, no. 6312, Nov. 2016, pp. 572–77. Pubmed, doi:10.1126/science.aaf8924.
Ji R-R, Chamessian A, Zhang Y-Q. Pain regulation by non-neuronal cells and inflammation. Science. 2016 Nov 4;354(6312):572–577.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

November 4, 2016

Volume

354

Issue

6312

Start / End Page

572 / 577

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • T-Lymphocytes
  • Spinal Cord
  • Rats
  • Pain
  • Nociceptors
  • Neuroglia
  • Neuritis
  • Neoplasms
  • Monocytes