Anticipation of monetary gain but not loss in healthy older adults.

Published

Journal Article

Although global declines in structure have been documented in the aging human brain, little is known about the functional integrity of the striatum and prefrontal cortex in older adults during incentive processing. We used event-related functional magnetic resonance imaging to determine whether younger and older adults differed in both self-reported and neural responsiveness to anticipated monetary gains and losses. The present study provides evidence for intact striatal and insular activation during gain anticipation with age, but shows a relative reduction in activation during loss anticipation. These findings suggest that there is an asymmetry in the processing of gains and losses in older adults that may have implications for decision-making.

Full Text

Duke Authors

Cited Authors

  • Samanez-Larkin, GR; Gibbs, SEB; Khanna, K; Nielsen, L; Carstensen, LL; Knutson, B

Published Date

  • June 2007

Published In

Volume / Issue

  • 10 / 6

Start / End Page

  • 787 - 791

PubMed ID

  • 17468751

Pubmed Central ID

  • 17468751

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/nn1894

Language

  • eng