Managing Respiratory Failure in Obstructive Lung Disease.


Journal Article (Review)

Exacerbations of obstructive lung disease are common causes of acute respiratory failure. Short-acting bronchodilators and systemic glucocorticoids are the foundation of pharmacologic management. For patients requiring ventilator support, use of noninvasive ventilation reduces the risk of mortality and progression to invasive mechanical ventilation. Challenges associated with invasive ventilation include ventilator dyssynchrony, air trapping, and dynamic hyperinflation. Careful monitoring and adjustment of ventilatory support parameters helps to optimize the patient-ventilator interaction and minimizes the risk of associated morbidity. Extracorporeal life support is an emerging treatment for refractory hypercapnic respiratory failure associated with obstructive lung disease.

Full Text

Duke Authors

Cited Authors

  • Bergin, SP; Rackley, CR

Published Date

  • December 2016

Published In

Volume / Issue

  • 37 / 4

Start / End Page

  • 659 - 667

PubMed ID

  • 27842746

Pubmed Central ID

  • 27842746

Electronic International Standard Serial Number (EISSN)

  • 1557-8216

Digital Object Identifier (DOI)

  • 10.1016/j.ccm.2016.07.006


  • eng

Conference Location

  • United States