Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • M.D., Georgetown University School of Medicine 2006
• 

  Previous Appointments & Affiliations

  • Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2020
  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2015 - 2020
  • Medical Instructor in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2013 - 2015
• Research
• 

  Selected Grants

  • Mallinckrodt MNK14344100: Phase 4 Multicenter randomized double blind placebo controlled pilot study to assess the efficacy and safety of H.P. Acthar Gel in subjects with Pulmonary Sarcoidosis 2018 - 2023
  • Prospective trial to validate safety of Hemolung Respiratory Assist System for COPD patients 2018 - 2023
  • Quantitative 129Xe Gas Exchange MRI for Idiopathic Pulmonary Fibrosis 2015 - 2017
  • CHEST ADVANCED CLINICAL TRAINING PROGRAM-Idiopathic Pulmonary Fibrosis awarded by American College of Chest Physicians 2017
  • CHEST ADVANCED CLINICAL TRAINING PROGRAM-Idiopathic Pulmonary Fibrosis 2016
• 

  External Relationships

  • Becton, Dickinson and Company
  • Inspira
  • Select Medical
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Toffaletti, J. G., and C. R. Rackley. Blood Gases and Critical Care Testing: Physiology, Clinical Interpretations, and Laboratory Applications, 2021. https://doi.org/10.1016/C2020-0-03128-2.
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  • Academic Articles

    • Cercone, Jessica L., Shawn J. Kram, Morgan A. Trammel, Craig R. Rackley, Hui-Jie Lee, James Merchant, and Bridgette L. Kram. “Effect of Initial Anticoagulation Targets on Bleeding and Thrombotic Complications for Patients With Acute Respiratory Distress Syndrome Receiving Extracorporeal Membrane Oxygenation.” J Cardiothorac Vasc Anesth 36, no. 9 (September 2022): 3561–69. https://doi.org/10.1053/j.jvca.2022.05.012.
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    • Rackley, Craig R., and Neil R. MacIntyre. “Finding the Value of the Specialized Weaning Center.” Respir Care 67, no. 3 (March 2022): 375–76. https://doi.org/10.4187/respcare.09985.
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    • MacIntyre, Neil, Craig Rackley, and Felix Khusid. “Fifty Years of Mechanical Ventilation-1970s to 2020.” Crit Care Med 49, no. 4 (April 1, 2021): 558–74. https://doi.org/10.1097/CCM.0000000000004894.
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    • Rackley, Craig R. “Monitoring During Mechanical Ventilation.” Respir Care 65, no. 6 (June 2020): 832–46. https://doi.org/10.4187/respcare.07812.
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    • Anderson, C., C. Tocchi, L. Morrison, and C. Rackley. “A Smart-Phrase to Improve Documentation of Supportive Measures for Idiopathic Pulmonary Fibrosis.” Journal for Nurse Practitioners 16, no. 2 (February 1, 2020): 126–30. https://doi.org/10.1016/j.nurpra.2019.09.008.
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    • Rankine, Leith J., Ziyi Wang, Jennifer M. Wang, Mu He, H Page McAdams, Joseph Mammarappallil, Craig R. Rackley, Bastiaan Driehuys, and Robert M. Tighe. “129Xenon Gas Exchange Magnetic Resonance Imaging as a Potential Prognostic Marker for Progression of Idiopathic Pulmonary Fibrosis.” Ann Am Thorac Soc 17, no. 1 (January 2020): 121–25. https://doi.org/10.1513/AnnalsATS.201905-413RL.
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    • Rackley, Craig R., and Neil R. MacIntyre. “Low Tidal Volumes for Everyone?” Chest 156, no. 4 (October 2019): 783–91. https://doi.org/10.1016/j.chest.2019.06.007.
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    • Bier, Elianna A., Scott H. Robertson, Geoffry M. Schrank, Craig Rackley, Joseph G. Mammarappallil, Sudarshan Rajagopal, H Page McAdams, and Bastiaan Driehuys. “A protocol for quantifying cardiogenic oscillations in dynamic 129 Xe gas exchange spectroscopy: The effects of idiopathic pulmonary fibrosis.” Nmr Biomed 32, no. 1 (January 2019): e4029. https://doi.org/10.1002/nbm.4029.
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    • MacIntyre, Neil R., Michael Gentile, John Davies, Stephen Bergin, Craig Rackley, and Anne Mathews. “Airway pressure release ventilation: a step forward?” Intensive Care Med 44, no. 2 (February 2018): 272. https://doi.org/10.1007/s00134-017-5012-9.
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    • Wang, Jennifer M., Scott H. Robertson, Ziyi Wang, Mu He, Rohan S. Virgincar, Geoffry M. Schrank, Rose Marie Smigla, et al. “Using hyperpolarized 129Xe MRI to quantify regional gas transfer in idiopathic pulmonary fibrosis.” Thorax 73, no. 1 (January 2018): 21–28. https://doi.org/10.1136/thoraxjnl-2017-210070.
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    • Robertson, Scott H., Rohan S. Virgincar, Elianna A. Bier, Mu He, Geoffrey M. Schrank, Rose Marie Smigla, Craig Rackley, H Page McAdams, and Bastiaan Driehuys. “Uncovering a third dissolved-phase 129 Xe resonance in the human lung: Quantifying spectroscopic features in healthy subjects and patients with idiopathic pulmonary fibrosis.” Magn Reson Med 78, no. 4 (October 2017): 1306–15. https://doi.org/10.1002/mrm.26533.
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    • Wang, Ziyi, Scott Haile Robertson, Jennifer Wang, Mu He, Rohan S. Virgincar, Geoffry M. Schrank, Elianna A. Bier, et al. “Quantitative analysis of hyperpolarized 129 Xe gas transfer MRI.” Med Phys 44, no. 6 (June 2017): 2415–28. https://doi.org/10.1002/mp.12264.
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    • Bergin, Stephen P., and Craig R. Rackley. “Managing Respiratory Failure in Obstructive Lung Disease.” Clin Chest Med 37, no. 4 (December 2016): 659–67. https://doi.org/10.1016/j.ccm.2016.07.006.
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    • Kaushik, S Sivaram, Scott H. Robertson, Matthew S. Freeman, Mu He, Kevin T. Kelly, Justus E. Roos, Craig R. Rackley, W Michael Foster, H Page McAdams, and Bastiaan Driehuys. “Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.” Magn Reson Med 75, no. 4 (April 2016): 1434–43. https://doi.org/10.1002/mrm.25675.
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    • Toffaletti, J. G., and C. R. Rackley. “Monitoring Oxygen Status.” Adv Clin Chem 77 (2016): 103–24. https://doi.org/10.1016/bs.acc.2016.06.003.
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    • Michaud, Gaëtane C., Colleen L. Channick, Chad R. Marion, Robert M. Tighe, James A. Town, Andrew M. Luks, Jeremy B. Richards, et al. “ATS Core Curriculum 2015. Part I: Adult Pulmonary Medicine.” Ann Am Thorac Soc 12, no. 9 (September 2015): 1387–97. https://doi.org/10.1513/AnnalsATS.201504-194CME.
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    • Kaushik, S Sivaram, Matthew S. Freeman, Suk W. Yoon, Maria G. Liljeroth, Jane V. Stiles, Justus E. Roos, W Michael Foster, Craig R. Rackley, H. P. McAdams, and Bastiaan Driehuys. “Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.” J Appl Physiol (1985) 117, no. 6 (September 15, 2014): 577–85. https://doi.org/10.1152/japplphysiol.00326.2014.
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    • Kaushik, S. S., T. Heacock, M. Freeman, K. T. Kelly, C. R. Rackley, J. Stiles, W. M. Foster, H. P. McAdams, and B. Driehuys. “Hyperpolarized 129xe Spectroscopy As A Biomarker For Gas-Transfer Impairment In Idiopathic Pulmonary Fibrosis.” American Journal of Respiratory and Critical Care Medicine 189 (January 1, 2014).
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    • Barkauskas, Christina E., Michael J. Cronce, Craig R. Rackley, Emily J. Bowie, Douglas R. Keene, Barry R. Stripp, Scott H. Randell, Paul W. Noble, and Brigid L. M. Hogan. “Type 2 alveolar cells are stem cells in adult lung.” J Clin Invest 123, no. 7 (July 2013): 3025–36. https://doi.org/10.1172/JCI68782.
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    • Rackley, Craig R., Joseph E. Levitt, Hanjing Zhuo, Michael A. Matthay, and Carolyn S. Calfee. “Clinical evidence of early acute lung injury often precedes the diagnosis of ALI.” J Intensive Care Med 28, no. 4 (2013): 241–46. https://doi.org/10.1177/0885066612450850.
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    • Chen, Huaiyong, Keitaro Matsumoto, Brian L. Brockway, Craig R. Rackley, Jiurong Liang, Joo-Hyeon Lee, Dianhua Jiang, et al. “Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury.” Stem Cells 30, no. 9 (September 2012): 1948–60. https://doi.org/10.1002/stem.1150.
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    • Rackley, Craig R., and Barry R. Stripp. “Building and maintaining the epithelium of the lung.” J Clin Invest 122, no. 8 (August 2012): 2724–30. https://doi.org/10.1172/JCI60519.
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    • Rackley, Craig R., and Eric B. Meltzer. “Throw caution to the wind instruments.” Chest 139, no. 3 (March 2011): 729. https://doi.org/10.1378/chest.10-2713.
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    • Lee, Joyce S., Xiao Su, Craig Rackley, Michael A. Matthay, and Naveen Gupta. “Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury.” Anat Rec (Hoboken) 294, no. 1 (January 2011): 165–72. https://doi.org/10.1002/ar.21244.
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    • Bonadonna, Desiree, Yaron D. Barac, David N. Ranney, Craig R. Rackley, Kevin Mumma, Jacob N. Schroder, Carmelo A. Milano, and Mani A. Daneshmand. “Interhospital ECMO Transport: Regional Focus.” Semin Thorac Cardiovasc Surg 31, no. 3 (n.d.): 327–34. https://doi.org/10.1053/j.semtcvs.2019.01.003.
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  • Conference Papers

    • Cercone, Jessica, Shawn Kram, Morgan Trammel, Craig Rackley, Hui-Jie Lee, James Jr Merchant, and Bridgette Kram. “ANTICOAGULATION TARGETS IN PATIENTS WITH ARDS RECEIVING EXTRACORPOREAL MEMBRANE OXYGENATION.” In Critical Care Medicine, 50:487–487, 2022.
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    • Lanham, Holly, Erica Konopka, Anne Mathews, Craig Rackley, Lexie Zidanyue Yang, Hui-Jie Lee, and Bridgette Kram. “EVALUATING ROCURONIUM AS AN ALTERNATIVE TO CISATRACURIUM IN ACUTE RESPIRATORY DISTRESS SYNDROME.” In Critical Care Medicine, 50:463–463, 2022.
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    • Moserowitz, S., E. H. Pratt, and C. Rackley. “Analysis of Bloodstream Infection in Patients with Femoral Venovenous ECMO cannulation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.
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    • Pratt, E. H., and C. Rackley. “Performance of RESP Score to Predict Survival in Patients with COVID-19 ARDS managed with VV-ECMO.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.
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    • Zheng, C., and C. Rackley. “Tracheostomy in Patients on VV-ECMO for Acute Respiratory Failure with High Body Mass Index and High Positive End-Expiratory Pressure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 205, 2022.
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    • Pratt, E. H., S. Mausert, M. D. Wilson, A. M. Pulsipher, A. Brucker, C. L. Green, D. Bonadonna, and C. Rackley. “Impact of a Daily, Respiratory Therapist ECMO Specialist Driven Protocol to Assess Readiness to Wean from VV-ECMO in Patients with ARDS.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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    • Pulsipher, A. M., E. H. Pratt, A. Brucker, C. Green, D. Bonadonna, and C. Rackley. “Hemoglobin Transfusion Thresholds in Patients on VV-ECMO for ARDS.” In American Journal of Respiratory and Critical Care Medicine, Vol. 203, 2021.
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    • Foote, H., D. Bonadonna, and C. Rackley. “When Is Prolonged Too Long? Outcomes for Extended Duration VV-ECMO in ARDS.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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    • Mummy, D., L. Rankine, Z. Wang, E. Bier, C. Rackley, L. D. Morrison, J. Mammarappallil, B. Driehuys, and R. M. Tighe. “Hyperpolarized 129Xe Magnetic Resonance Imaging Is Sensitive to Therapy Response in Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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    • Rankine, L., Z. Wang, J. Wang, M. He, H. McAdams, J. Mammarappallil, C. Rackley, B. Driehuys, and R. Tighe. “Disease Progression in Idiopathic Pulmonary Fibrosis: The Potential for Stratifying Patients Using Hyperpolarized Xenon-129 Magnetic Resonance Imaging.” In Medical Physics, 46:E300–E300. WILEY, 2019.
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    • Moulton, N., L. J. Emerson, C. Thurman, B. A. Blough, D. Bonadonna, and C. Rackley. “Blood Transfusion Thresholds and Outcomes in Patients Requiring Veno-Venous Extracorporeal Membrane Oxygenation for Acute Respiratory Failure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Thaniyavarn, T., E. N. Pavlisko, C. R. Rackley, and H. A. Ali. “Post Lung Transplant Status Asthmaticus Complicating Severe Primary Graft Dysfunction Necessitating Urgent Redo-Bilateral Lung Transplantation.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Tighe, R. M., L. Rankine, Z. Wang, J. Wang, M. He, C. Rackley, H. McAdams, J. Mammarappallil, and B. Driehuys. “Longitudinal Follow Up After Xe-129 MRI Scan; Potential to Stratify Idiopathic Pulmonary Fibrosis Disease Progression.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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    • Blough, B., D. Bonadonna, M. A. Daneshmand, and C. R. Rackley. “Fluid Administration And Survival In Patients Receiving Veno-Venous Ecmo For Ards.” In American Journal of Respiratory and Critical Care Medicine, Vol. 195. AMER THORACIC SOC, 2017.
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    • He, M., S. H. Robertson, J. M. Wang, C. R. Rackley, H. P. McAdams, and B. Driehuys. “Differentiating Early Stage And Later Stage Ipf Using Hyperpolarized 129xe Ventilation Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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    • Wang, J. M., S. H. Robertson, M. He, R. S. Virgincar, G. M. Schrank, R. Smigla, T. O’Riordan, et al. “Using Hyperpolarized 129xe Imaging To Quantify Apical Vs. Basal And Central Vs. Peripheral Gas Exchange Impairment In Idiopathic Pulmonary Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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