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Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease.

Publication ,  Journal Article
Bliden, KP; Chaudhary, R; Lopez, LR; Damrongwatanasuk, R; Guyer, K; Gesheff, MG; Franzese, CJ; Kaza, H; Tantry, US; Gurbel, PA
Published in: Am J Cardiol
September 1, 2016

Oxidized low-density lipoprotein (oxLDL) and β2-glycoprotein I (β2GPI) have been identified in human atherosclerotic lesions and when complexed have been implicated as a pro-atherothrombotic antigen. We examined the association of free oxLDL and oxLDL-β2GPI complex in patients with coronary artery disease who underwent elective cardiac catheterization. Serum was collected from patients with suspected coronary artery disease immediately before elective cardiac catheterization who were either treated (n = 385) or not treated (n = 150) with statins and from healthy volunteers (n = 134). OxLDL and oxLDL-β2GPI complex levels were determined by enzyme-linked immunosorbent assay. Disease severity was defined angiographically as none-minimal (<20%), moderate (20% to 75%), and severe (>75%) luminal diameter obstruction of any major coronary vessel. Both oxLDL and oxLDL-β2GPI complex were lower in patients on statins (p <0.001). In statin-naive patients, oxLDL-β2GPI complex, but not free oxLDL, was associated with severe coronary artery disease (p = 0.036). However, no association was observed in patients on statins. LDL4 and triglycerides increased with oxLDL-β2GPI complex quartiles (p = 0.001). OxLDL-β2GPI complex (>0.32 U/ml) was predictive of severe atherosclerosis by receiver-operating characteristic curve analysis in statin-naive patients (area under the curve 0.66, p = 0.002). In conclusion, oxLDL-β2GPI appears more predictive of coronary artery disease severity than oxLDL alone in statin-naive patients.

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Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

September 1, 2016

Volume

118

Issue

5

Start / End Page

673 / 678

Location

United States

Related Subject Headings

  • beta 2-Glycoprotein I
  • Sensitivity and Specificity
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Lipoproteins, LDL
  • Humans
  • Female
  • Coronary Artery Disease
  • Cardiovascular System & Hematology
 

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Bliden, K. P., Chaudhary, R., Lopez, L. R., Damrongwatanasuk, R., Guyer, K., Gesheff, M. G., … Gurbel, P. A. (2016). Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease. Am J Cardiol, 118(5), 673–678. https://doi.org/10.1016/j.amjcard.2016.06.023
Bliden, Kevin P., Rahul Chaudhary, Luis R. Lopez, Rongras Damrongwatanasuk, Kirk Guyer, Martin G. Gesheff, Christopher J. Franzese, Himabindu Kaza, Udaya S. Tantry, and Paul A. Gurbel. “Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease.Am J Cardiol 118, no. 5 (September 1, 2016): 673–78. https://doi.org/10.1016/j.amjcard.2016.06.023.
Bliden KP, Chaudhary R, Lopez LR, Damrongwatanasuk R, Guyer K, Gesheff MG, et al. Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease. Am J Cardiol. 2016 Sep 1;118(5):673–8.
Bliden, Kevin P., et al. “Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease.Am J Cardiol, vol. 118, no. 5, Sept. 2016, pp. 673–78. Pubmed, doi:10.1016/j.amjcard.2016.06.023.
Bliden KP, Chaudhary R, Lopez LR, Damrongwatanasuk R, Guyer K, Gesheff MG, Franzese CJ, Kaza H, Tantry US, Gurbel PA. Oxidized Low-Density Lipoprotein-β2-Glycoprotein I Complex But Not Free Oxidized LDL Is Associated With the Presence and Severity of Coronary Artery Disease. Am J Cardiol. 2016 Sep 1;118(5):673–678.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

September 1, 2016

Volume

118

Issue

5

Start / End Page

673 / 678

Location

United States

Related Subject Headings

  • beta 2-Glycoprotein I
  • Sensitivity and Specificity
  • Predictive Value of Tests
  • Middle Aged
  • Male
  • Lipoproteins, LDL
  • Humans
  • Female
  • Coronary Artery Disease
  • Cardiovascular System & Hematology