Acute administration of acyl, but not desacyl ghrelin, decreases blood pressure in healthy humans.

Published

Journal Article

OBJECTIVE: To compare the effects of acyl ghrelin (AG) and desacyl ghrelin (DAG) on blood pressure (BP), heart rate (HR) and other autonomic parameters in healthy humans and to elucidate the hormonal mechanisms through which AG could exert its cardiovascular effects. DESIGN: Seventeen healthy participants underwent frequent monitoring of systolic (sBP) and diastolic blood pressure (dBP), HR, respiratory rate (RR) and body surface temperature (Temp) during continuous infusion of AG, DAG, combined AG + DAG or saline control before and during an IV glucose tolerance test on 4 separate days. Plasma catecholamines, renin and aldosterone levels were also measured. Differences in outcome measures between treatment groups were assessed using mixed-model analysis. RESULTS: Compared to the saline control, AG and combined AG + DAG infusions decreased sBP, dBP, mean arterial blood pressure (MAP), HR and Temp. In contrast, DAG infusion did not alter BP, RR or Temp, but did decrease HR. The AG and AG + DAG infusions also raised plasma aldosterone levels compared to saline (P < 0.001) without affecting renin or catecholamine levels. CONCLUSIONS: The decrease in BP, HR, RR and Temp with AG infusion suggests mediation through the autonomic nervous system. The lack of response to DAG suggests that these autonomic effects require activation of the ghrelin receptor.

Full Text

Duke Authors

Cited Authors

  • Zhang, CJ; Bidlingmaier, M; Altaye, M; Page, LC; D'Alessio, D; Tschöp, MH; Tong, J

Published Date

  • February 2017

Published In

Volume / Issue

  • 176 / 2

Start / End Page

  • 123 - 132

PubMed ID

  • 27913606

Pubmed Central ID

  • 27913606

Electronic International Standard Serial Number (EISSN)

  • 1479-683X

Digital Object Identifier (DOI)

  • 10.1530/EJE-16-0789

Language

  • eng

Conference Location

  • England