Protect this house: cytosolic sensing of viruses.
Publication
, Journal Article
McFadden, MJ; Gokhale, NS; Horner, SM
Published in: Curr Opin Virol
February 2017
The ability to recognize invading viral pathogens and to distinguish their components from those of the host cell is critical to initiate the innate immune response. The efficiency of this detection is an important factor in determining the susceptibility of the cell to viral infection. Innate sensing of viruses is, therefore, an indispensable step in the line of defense for cells and organisms. Recent discoveries have uncovered novel sensors of viral components and hallmarks of infection, as well as mechanisms by which cells discriminate between self and non-self. This review highlights the mechanisms used by cells to detect viral pathogens in the cytosol, and recent advances in the field of cytosolic sensing of viruses.
Duke Scholars
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Published In
Curr Opin Virol
DOI
EISSN
1879-6265
Publication Date
February 2017
Volume
22
Start / End Page
36 / 43
Location
Netherlands
Related Subject Headings
- Viruses
- Receptors, Immunologic
- Immunity, Innate
- Humans
- Cytosol
- Animals
- 3107 Microbiology
- 1108 Medical Microbiology
- 0605 Microbiology
Citation
APA
Chicago
ICMJE
MLA
NLM
McFadden, M. J., Gokhale, N. S., & Horner, S. M. (2017). Protect this house: cytosolic sensing of viruses. Curr Opin Virol, 22, 36–43. https://doi.org/10.1016/j.coviro.2016.11.012
McFadden, Michael J., Nandan S. Gokhale, and Stacy M. Horner. “Protect this house: cytosolic sensing of viruses.” Curr Opin Virol 22 (February 2017): 36–43. https://doi.org/10.1016/j.coviro.2016.11.012.
McFadden MJ, Gokhale NS, Horner SM. Protect this house: cytosolic sensing of viruses. Curr Opin Virol. 2017 Feb;22:36–43.
McFadden, Michael J., et al. “Protect this house: cytosolic sensing of viruses.” Curr Opin Virol, vol. 22, Feb. 2017, pp. 36–43. Pubmed, doi:10.1016/j.coviro.2016.11.012.
McFadden MJ, Gokhale NS, Horner SM. Protect this house: cytosolic sensing of viruses. Curr Opin Virol. 2017 Feb;22:36–43.
Published In
Curr Opin Virol
DOI
EISSN
1879-6265
Publication Date
February 2017
Volume
22
Start / End Page
36 / 43
Location
Netherlands
Related Subject Headings
- Viruses
- Receptors, Immunologic
- Immunity, Innate
- Humans
- Cytosol
- Animals
- 3107 Microbiology
- 1108 Medical Microbiology
- 0605 Microbiology