Elements of biological oscillations in time and space.

Journal Article (Journal Article)

Oscillations in time and space are ubiquitous in nature and play critical roles in dynamic cellular processes. Although the molecular mechanisms underlying the generation of the dynamics are diverse, several distinct regulatory elements have been recognized as being critical in producing and modulating oscillatory dynamics. These include negative and positive feedback, time delay, nonlinearity in regulation, and random fluctuations ('noise'). Here we discuss the specific roles of these five elements in promoting or attenuating oscillatory dynamics, by drawing on insights from quantitative analyses of natural or synthetic biological networks.

Full Text

Duke Authors

Cited Authors

  • Cao, Y; Lopatkin, A; You, L

Published Date

  • December 2016

Published In

Volume / Issue

  • 23 / 12

Start / End Page

  • 1030 - 1034

PubMed ID

  • 27922613

Electronic International Standard Serial Number (EISSN)

  • 1545-9985

International Standard Serial Number (ISSN)

  • 1545-9993

Digital Object Identifier (DOI)

  • 10.1038/nsmb.3320


  • eng