Serum cholesterol and risk of lower urinary tract symptoms progression: Results from the Reduction by Dutasteride of Prostate Cancer Events study.

Journal Article (Multicenter Study;Journal Article)

Objective

To determine if cholesterol is a risk factor for the development of lower urinary tract symptoms in asymptomatic men.

Methods

A post-hoc analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study was carried out in 2323 men with baseline International Prostate Symptom Score <8 and not taking benign prostatic hyperplasia or cholesterol medications. Cox proportion models were used to test the association between cholesterol, high-density lipoprotein, low-density lipoprotein and the cholesterol : high-density lipoprotein ratio with incident lower urinary tract symptoms, defined as first report of medical treatment, surgery or two reports of an International Prostate Symptom Score >14.

Results

A total of 253 men (10.9%) developed incident lower urinary tract symptoms. On crude analysis, higher high-density lipoprotein was associated with a decreased lower urinary tract symptoms risk (hazard ratio 0.89, P = 0.024), whereas total cholesterol and low-density lipoprotein showed no association. After multivariable adjustment, the association between high-density lipoprotein and incident lower urinary tract symptoms remained significant (hazard ratio 0.89, P = 0.044), whereas no association was observed for low-density lipoprotein (P = 0.611). There was a trend for higher cholesterol to be linked with higher lower urinary tract symptoms risk, though this was not statistically significant (hazard ratio 1.04, P = 0.054). A higher cholesterol : high-density lipoprotein ratio was associated with increased lower urinary tract symptoms risk on crude (hazard ratio 1.11, P = 0.016) and adjusted models (hazard ratio 1.12, P = 0.012).

Conclusions

Among asymptomatic men participating in the REDUCE study, higher cholesterol was associated with increased incident lower urinary tract symptoms risk, though the association was not significant. A higher cholesterol : high-density lipoprotein ratio was associated with increased incident lower urinary tract symptoms, whereas higher high-density lipoprotein was protective. These findings suggest dyslipidemia might play a role in lower urinary tract symptoms progression.

Full Text

Duke Authors

Cited Authors

  • Feng, T; Howard, LE; Vidal, AC; Moreira, DM; Castro-Santamaria, R; Andriole, GL; Freedland, SJ

Published Date

  • February 2017

Published In

Volume / Issue

  • 24 / 2

Start / End Page

  • 151 - 156

PubMed ID

  • 28004415

Pubmed Central ID

  • 28004415

Electronic International Standard Serial Number (EISSN)

  • 1442-2042

International Standard Serial Number (ISSN)

  • 0919-8172

Digital Object Identifier (DOI)

  • 10.1111/iju.13265

Language

  • eng