Scholars@Duke

• Research
• 

  Selected Grants

  • PSA - Lauren Howard - A Retrospective Description of Patient Characteristics, Management, and Outcomes 2017 - 2020
  • PSA for Lauren Howard 2014 - 2019
  • Randomized Controlled Clinical Trial of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy for Prostate Cancer awarded by University of California, Los Angeles 2017 - 2019
  • Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Fowke, Jay H., Tatsuki Koyama, Qi Dai, S Lilly Zheng, Jianfeng Xu, Lauren E. Howard, and Stephen J. Freedland. “Blood and dietary magnesium levels are not linked with lower prostate cancer risk in black or white men..” Cancer Letters 449 (May 2019): 99–105. https://doi.org/10.1016/j.canlet.2019.02.023.
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    • Scott-Emuakpor, Jem, Emma Allot, Stacy A. Johnson, Lauren E. Howard, Everardo Macias, Stephen J. Freedland, and Susan B. Gurley. “Angiotensin receptor signaling and prostate tumor growth in mice..” J Exp Ther Oncol 11, no. 2 (September 2017): 107–15.
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    • Freedland, Stephen J., Lauren E. Howard, Brian T. Hanyok, Vishnu K. Kadiyala, Jameson Y. Kuang, Colette A. Whitney, Floyd R. Wilks, et al. “Validation of a bone scan positivity risk table in non-metastatic castration-resistant prostate cancer..” Bju International 118, no. 4 (October 2016): 570–77. https://doi.org/10.1111/bju.13405.
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    • Freedland, Stephen J., Voleak Choeurng, Lauren Howard, Amanda De Hoedt, Marguerite du Plessis, Kasra Yousefi, Lucia L. Lam, et al. “Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy..” European Urology 70, no. 4 (October 2016): 588–96. https://doi.org/10.1016/j.eururo.2016.01.008.
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    • Fischer, Sean, Daniel Lin, Ross M. Simon, Lauren E. Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, et al. “Do all men with pathological Gleason score 8-10 prostate cancer have poor outcomes? Results from the SEARCH database..” Bju International 118, no. 2 (August 2016): 250–57. https://doi.org/10.1111/bju.13319.
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    • Simon, Ross M., Lauren E. Howard, Stephen J. Freedland, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matthew R. Cooperberg, and Adriana C. Vidal. “Adverse pathology and undetectable ultrasensitive prostate-specific antigen after radical prostatectomy: is adjuvant radiation warranted?.” Bju International 117, no. 6 (June 2016): 897–903. https://doi.org/10.1111/bju.13182.
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    • Simon, Ross M., Lauren E. Howard, Daniel M. Moreira, Claus Roehrborn, Adriana C. Vidal, Ramiro Castro-Santamaria, and Stephen J. Freedland. “Does Prostate Size Predict the Development of Incident Lower Urinary Tract Symptoms in Men with Mild to No Current Symptoms? Results from the REDUCE Trial..” European Urology 69, no. 5 (May 2016): 885–91. https://doi.org/10.1016/j.eururo.2015.12.002.
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    • Allott, Emma H., Lauren E. Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matthew R. Cooperberg, and Stephen J. Freedland. “Racial Differences in the Association Between Preoperative Serum Cholesterol and Prostate Cancer Recurrence: Results from the SEARCH Database..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 25, no. 3 (March 2016): 547–54. https://doi.org/10.1158/1055-9965.EPI-15-0876.
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    • McGinley, Kathleen F., Xizi Sun, Lauren E. Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matthew R. Cooperberg, and Stephen J. Freedland. “Utilization and impact of surgical technique on the performance of pelvic lymph node dissection at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database..” International Journal of Urology : Official Journal of the Japanese Urological Association 23, no. 3 (March 2016): 241–46. https://doi.org/10.1111/iju.13027.
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    • Mithal, Prabhakar, Lauren E. Howard, William J. Aronson, Martha K. Terris, Matthew R. Cooperberg, Christopher J. Kane, Christopher Amling, and Stephen J. Freedland. “Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort..” Bju International 117, no. 2 (February 2016): 244–48. https://doi.org/10.1111/bju.13181.
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    • Hanyok, Brian T., Lauren E. Howard, Christopher L. Amling, William J. Aronson, Matthew R. Cooperberg, Christopher J. Kane, Martha K. Terris, Edwin M. Posadas, and Stephen J. Freedland. “Is computed tomography a necessary part of a metastatic evaluation for castration-resistant prostate cancer? Results from the Shared Equal Access Regional Cancer Hospital Database..” Cancer 122, no. 2 (January 2016): 222–29. https://doi.org/10.1002/cncr.29748.
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    • Klaassen, Zachary, Lauren Howard, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, and Stephen J. Freedland. “Does larger tumor volume explain the higher prostate specific antigen levels in black men with prostate cancer--Results from the SEARCH database..” Cancer Epidemiology 39, no. 6 (December 2015): 1066–70. https://doi.org/10.1016/j.canep.2015.09.007.
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    • Moreira, D. M., L. E. Howard, K. N. Sourbeer, H. S. Amarasekara, L. C. Chow, D. C. Cockrell, B. T. Hanyok, et al. “Predicting bone scan positivity in non-metastatic castration-resistant prostate cancer..” Prostate Cancer and Prostatic Diseases 18, no. 4 (December 2015): 333–37. https://doi.org/10.1038/pcan.2015.25.
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    • Zapata, Daniel, Lauren E. Howard, Emma H. Allott, Robert J. Hamilton, Kenneth Goldberg, and Stephen J. Freedland. “Is PSA related to serum cholesterol and does the relationship differ between black and white men?.” Prostate 75, no. 16 (December 2015): 1877–85. https://doi.org/10.1002/pros.23069.
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    • Feng, Tom, Xizi Sun, Lauren E. Howard, Adriana C. Vidal, Alexis R. Gaines, Daniel M. Moreira, Ramiro Castro-Santamaria, Gerald L. Andriole, and Stephen J. Freedland. “Metformin use and risk of prostate cancer: results from the REDUCE study..” Cancer Prevention Research (Philadelphia, Pa.) 8, no. 11 (November 2015): 1055–60. https://doi.org/10.1158/1940-6207.CAPR-15-0141.
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    • Vidal, Adriana C., Lauren E. Howard, Daniel M. Moreira, Ramiro Castro-Santamaria, Gerald L. Andriole, and Stephen J. Freedland. “Does Obesity Modify the Ability of Prebiopsy Prostate Specific Antigen to Detect Prostate Cancer on Repeat Biopsy? Results from the REDUCE Study..” The Journal of Urology 194, no. 1 (July 2015): 52–57. https://doi.org/10.1016/j.juro.2015.01.111.
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    • Zapata, Daniel F., Lauren E. Howard, William J. Aronson, Christopher J. Kane, Martha K. Terris, Christopher L. Amling, Matthew R. Cooperberg, and Stephen J. Freedland. “Smoking is a predictor of adverse pathological features at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database..” International Journal of Urology : Official Journal of the Japanese Urological Association 22, no. 7 (July 2015): 658–62. https://doi.org/10.1111/iju.12773.
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    • Simon, Ross M., Lauren Howard, Daniel Zapata, Jennifer Frank, Stephen J. Freedland, and Adriana C. Vidal. “The association of exercise with both erectile and sexual function in black and white men..” The Journal of Sexual Medicine 12, no. 5 (May 2015): 1202–10. https://doi.org/10.1111/jsm.12869.
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    • Sourbeer, Katharine N., Lauren E. Howard, Gerald L. Andriole, Daniel M. Moreira, Ramiro Castro-Santamaria, Stephen J. Freedland, and Adriana C. Vidal. “Metabolic syndrome-like components and prostate cancer risk: results from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study..” Bju International 115, no. 5 (May 2015): 736–43. https://doi.org/10.1111/bju.12843.
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    • Mithal, Prabhakar, Lauren E. Howard, William J. Aronson, Christopher J. Kane, Matthew R. Cooperberg, Martha K. Terris, Christopher L. Amling, and Stephen J. Freedland. “Prostate-specific antigen level, stage or Gleason score: which is best for predicting outcomes after radical prostatectomy, and does it vary by the outcome being measured? Results from Shared Equal Access Regional Cancer Hospital database..” International Journal of Urology : Official Journal of the Japanese Urological Association 22, no. 4 (April 2015): 362–66. https://doi.org/10.1111/iju.12704.
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    • Sourbeer, Katharine N., Lauren E. Howard, Daniel M. Moreira, Hiruni S. Amarasekara, Lydia D. Chow, Dillon C. Cockrell, Brian T. Hanyok, et al. “Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: results from the SEARCH database..” The Journal of Urology 193, no. 4 (April 2015): 1232–38. https://doi.org/10.1016/j.juro.2014.11.014.
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    • Vidal, Adriana C., Christina D. Williams, Emma H. Allott, Lauren E. Howard, Delores J. Grant, Megan McPhail, Katharine N. Sourbeer, et al. “Carbohydrate intake, glycemic index and prostate cancer risk..” Prostate 75, no. 4 (March 1, 2015): 430–39. https://doi.org/10.1002/pros.22929.
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    • Vidal, Adriana C., Lauren E. Howard, Daniel M. Moreira, Ramiro Castro-Santamaria, Gerald L. Andriole, and Stephen J. Freedland. “Aspirin, NSAIDs, and risk of prostate cancer: results from the REDUCE study..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 21, no. 4 (February 2015): 756–62. https://doi.org/10.1158/1078-0432.CCR-14-2235.
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    • Fowke, Jay H., Lauren Howard, Gerald L. Andriole, and Stephen J. Freedland. “Alcohol intake increases high-grade prostate cancer risk among men taking dutasteride in the REDUCE trial..” European Urology 66, no. 6 (December 2014): 1133–38. https://doi.org/10.1016/j.eururo.2014.01.037.
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    • Vidal, Adriana C., Lauren E. Howard, Daniel M. Moreira, Ramiro Castro-Santamaria, Gerald L. Andriole, and Stephen J. Freedland. “Obesity increases the risk for high-grade prostate cancer: results from the REDUCE study..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23, no. 12 (December 2014): 2936–42. https://doi.org/10.1158/1055-9965.EPI-14-0795.
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    • Allott, Emma H., Lauren E. Howard, Hai-Jun Song, Katharine N. Sourbeer, Bridget F. Koontz, Joseph K. Salama, and Stephen J. Freedland. “Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy..” Cancer Epidemiol Biomarkers Prev 23, no. 11 (November 2014): 2404–12. https://doi.org/10.1158/1055-9965.EPI-14-0236.
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    • Allott, Emma H., Lauren E. Howard, Matthew R. Cooperberg, Christopher J. Kane, William J. Aronson, Martha K. Terris, Christopher L. Amling, and Stephen J. Freedland. “Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database..” Bju International 114, no. 5 (November 2014): 661–66. https://doi.org/10.1111/bju.12720.
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    • Allott, Emma H., Lauren E. Howard, Matthew R. Cooperberg, Christopher J. Kane, William J. Aronson, Martha K. Terris, Christopher L. Amling, and Stephen J. Freedland. “Serum lipid profile and risk of prostate cancer recurrence: Results from the SEARCH database..” Cancer Epidemiology, Biomarkers & Prevention : A Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23, no. 11 (November 2014): 2349–56. https://doi.org/10.1158/1055-9965.EPI-14-0458.
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    • Ho, Tammy, Lauren E. Howard, Adriana C. Vidal, Leah Gerber, Daniel Moreira, Madeleine McKeever, Gerald Andriole, Ramiro Castro-Santamaria, and Stephen J. Freedland. “Smoking and risk of low- and high-grade prostate cancer: results from the REDUCE study..” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 20, no. 20 (October 2014): 5331–38. https://doi.org/10.1158/1078-0432.CCR-13-2394.
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    • Moreira, D. M., M. R. Cooperberg, L. E. Howard, W. J. Aronson, C. J. Kane, M. K. Terris, C. L. Amling, M. Kuchibhatla, and S. J. Freedland. “Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database..” Prostate Cancer Prostatic Dis 17, no. 1 (March 2014): 91–96. https://doi.org/10.1038/pcan.2013.59.
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  • Conference Papers

    • Klaassen, Zachary, Abhay A. Singh, Lauren E. Howard, Zhaoyong Feng, Bruce Trock, Martha K. Terris, William J. Aronson, et al. “Is clinical stage T2c prostate cancer an intermediate- or high-risk disease?.” In Cancer, 121:1414–21, 2015. https://doi.org/10.1002/cncr.29147.
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    • McGinley, Kathleen F., Xizi Sun, Lauren E. Howard, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher L. Amling, Matthew R. Cooperberg, and Stephen J. Freedland. “Can Gleason 7 prostate cancer ever be low-risk? Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database..” In Journal of Clinical Oncology, 33:57–57. American Society of Clinical Oncology (ASCO), 2015. https://doi.org/10.1200/jco.2015.33.7_suppl.57.
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    • Vidal, Adriana C., Christina C. Williams, Emma H. Allott, Lauren E. Howard, Delores J. Grant, Megan McPhail, Katharine N. Sourbeer, Paolo Boffetta, Cathrine Hoyo, and Stephen J. Freedland. “Abstract 1265: Carbohydrate intake, glycemic index and prostate cancer risk.” In Epidemiology. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-1265.
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