Lauren Howard | Scholars@Duke

Lauren Howard
Biostatistician III

Master of Biostatistics, Duke University School of Medicine. 2014
Bachelor of Arts in Mathematics, Vassar College. 2012

Overview: Lauren collaborates with the Durham VA on prostate cancer research. She has experience with data management, data analysis, and preparation and editing of manuscripts. Most of her projects use observational data to study how racial disparities, lifestyle factors, and risk stratification affect prostate cancer incidence and outcomes. Some of her projects have involved time-varying covariates, competing risks, and repeated measures. She is interested in methods for handling bias and confounding in observational research.

Current Appointments & Affiliations

Biostatistician III, Biostatistics & Bioinformatics, Basic Science Departments

Contact Information

2424 Erwin Road, Duke Cancer Institute Box 2717, Durham, NC 27710
lauren.howard@duke.edu +1 919 668 5893
LinkedIN

Research
Selected Grants
- PSA - Lauren Howard - A Retrospective Description of Patient Characteristics, Management, and Outcomes awarded by Institute for Medical Research, Inc. 2017 - 2020
- PSA for Lauren Howard awarded by Institute for Medical Research, Inc. 2014 - 2019
- Randomized Controlled Clinical Trial of Carbohydrate Restriction Among Men Initiating Androgen Deprivation Therapy for Prostate Cancer awarded by University of California - Los Angeles 2017 - 2019
- Duke CTSA (UL1) awarded by National Institutes of Health 2013 - 2018
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Scott-Emuakpor, J, Allot, E, Johnson, SA, Howard, LE, Macias, E, Freedland, SJ, and Gurley, SB. "Angiotensin receptor signaling and prostate tumor growth in mice." Journal of Experimental Therapeutics & Oncology 11, no. 2 (September 2017): 107-115.
  - Freedland, SJ, Choeurng, V, Howard, L, De Hoedt, A, du Plessis, M, Yousefi, K, Lam, LL, Buerki, C, Ra, S, Robbins, B, Trabulsi, EJ, Shah, NL, Abdollah, F, Feng, FY, Davicioni, E, Dicker, AP, Karnes, RJ, and Den, RB. "Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy." European urology 70, no. 4 (October 2016): 588-596. Full Text
  - Freedland, SJ, Howard, LE, Hanyok, BT, Kadiyala, VK, Kuang, JY, Whitney, CA, Wilks, FR, Kane, CJ, Terris, MK, Amling, CL, Cooperberg, MR, Aronson, WJ, and Moreira, DM. "Validation of a bone scan positivity risk table in non-metastatic castration-resistant prostate cancer." BJU international 118, no. 4 (October 2016): 570-577. Full Text
  - Fischer, S, Lin, D, Simon, RM, Howard, LE, Aronson, WJ, Terris, MK, Kane, CJ, Amling, CL, Cooperberg, MR, Freedland, SJ, and Vidal, AC. "Do all men with pathological Gleason score 8-10 prostate cancer have poor outcomes? Results from the SEARCH database." BJU international 118, no. 2 (August 2016): 250-257. Full Text
  - Simon, RM, Howard, LE, Freedland, SJ, Aronson, WJ, Terris, MK, Kane, CJ, Amling, CL, Cooperberg, MR, and Vidal, AC. "Adverse pathology and undetectable ultrasensitive prostate-specific antigen after radical prostatectomy: is adjuvant radiation warranted?." Bju International 117, no. 6 (June 2016): 897-903. Full Text
  - Simon, RM, Howard, LE, Moreira, DM, Roehrborn, C, Vidal, AC, Castro-Santamaria, R, and Freedland, SJ. "Does Prostate Size Predict the Development of Incident Lower Urinary Tract Symptoms in Men with Mild to No Current Symptoms? Results from the REDUCE Trial." European urology 69, no. 5 (May 2016): 885-891. Full Text
  - Allott, EH, Howard, LE, Aronson, WJ, Terris, MK, Kane, CJ, Amling, CL, Cooperberg, MR, and Freedland, SJ. "Racial Differences in the Association Between Preoperative Serum Cholesterol and Prostate Cancer Recurrence: Results from the SEARCH Database." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 25, no. 3 (March 2016): 547-554. Full Text
  - McGinley, KF, Sun, X, Howard, LE, Aronson, WJ, Terris, MK, Kane, CJ, Amling, CL, Cooperberg, MR, and Freedland, SJ. "Utilization and impact of surgical technique on the performance of pelvic lymph node dissection at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database." International Journal of Urology : Official Journal of the Japanese Urological Association 23, no. 3 (March 2016): 241-246. Full Text
  - Mithal, P, Howard, LE, Aronson, WJ, Terris, MK, Cooperberg, MR, Kane, CJ, Amling, C, and Freedland, SJ. "Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort." Bju International 117, no. 2 (February 2016): 244-248. Full Text
  - Hanyok, BT, Howard, LE, Amling, CL, Aronson, WJ, Cooperberg, MR, Kane, CJ, Terris, MK, Posadas, EM, and Freedland, SJ. "Is computed tomography a necessary part of a metastatic evaluation for castration-resistant prostate cancer? Results from the Shared Equal Access Regional Cancer Hospital Database." Cancer 122, no. 2 (January 2016): 222-229. Full Text
  - Klaassen, Z, Howard, L, Terris, MK, Aronson, WJ, Cooperberg, MR, Amling, CL, Kane, CJ, and Freedland, SJ. "Does larger tumor volume explain the higher prostate specific antigen levels in black men with prostate cancer--Results from the SEARCH database." Cancer Epidemiology 39, no. 6 (December 2015): 1066-1070. Full Text
  - Moreira, DM, Howard, LE, Sourbeer, KN, Amarasekara, HS, Chow, LC, Cockrell, DC, Hanyok, BT, Pratson, CL, Aronson, WJ, Kane, CJ, Terris, MK, Amling, CL, Cooperberg, MR, Liede, A, and Freedland, SJ. "Predicting bone scan positivity in non-metastatic castration-resistant prostate cancer." Prostate Cancer and Prostatic Diseases 18, no. 4 (December 2015): 333-337. Full Text
  - Zapata, D, Howard, LE, Allott, EH, Hamilton, RJ, Goldberg, K, and Freedland, SJ. "Is PSA related to serum cholesterol and does the relationship differ between black and white men?." The Prostate 75, no. 16 (December 2015): 1877-1885. Full Text
  - Feng, T, Sun, X, Howard, LE, Vidal, AC, Gaines, AR, Moreira, DM, Castro-Santamaria, R, Andriole, GL, and Freedland, SJ. "Metformin use and risk of prostate cancer: results from the REDUCE study." Cancer Prevention Research (Philadelphia, Pa.) 8, no. 11 (November 2015): 1055-1060. Full Text
  - Vidal, AC, Howard, LE, Moreira, DM, Castro-Santamaria, R, Andriole, GL, and Freedland, SJ. "Does Obesity Modify the Ability of Prebiopsy Prostate Specific Antigen to Detect Prostate Cancer on Repeat Biopsy? Results from the REDUCE Study." The Journal of urology 194, no. 1 (July 2015): 52-57. Full Text
  - Zapata, DF, Howard, LE, Aronson, WJ, Kane, CJ, Terris, MK, Amling, CL, Cooperberg, MR, and Freedland, SJ. "Smoking is a predictor of adverse pathological features at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database." International Journal of Urology : Official Journal of the Japanese Urological Association 22, no. 7 (July 2015): 658-662. Full Text
  - Klaassen, Z, Singh, AA, Howard, LE, Feng, Z, Trock, B, Terris, MK, Aronson, WJ, Cooperberg, MR, Amling, CL, Kane, CJ, Partin, A, Han, M, and Freedland, SJ. "Is Clinical Stage T2c Prostate Cancer an Intermediate- or High-Risk Disease?." CANCER 121, no. 9 (May 1, 2015): 1414-1421. Full Text Link to Item
  - Simon, RM, Howard, L, Zapata, D, Frank, J, Freedland, SJ, and Vidal, AC. "The association of exercise with both erectile and sexual function in black and white men." The journal of sexual medicine 12, no. 5 (May 2015): 1202-1210. Full Text
  - Sourbeer, KN, Howard, LE, Andriole, GL, Moreira, DM, Castro-Santamaria, R, Freedland, SJ, and Vidal, AC. "Metabolic syndrome-like components and prostate cancer risk: results from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study." Bju International 115, no. 5 (May 2015): 736-743. Full Text
  - Mithal, P, Howard, LE, Aronson, WJ, Kane, CJ, Cooperberg, MR, Terris, MK, Amling, CL, and Freedland, SJ. "Prostate-specific antigen level, stage or Gleason score: which is best for predicting outcomes after radical prostatectomy, and does it vary by the outcome being measured? Results from Shared Equal Access Regional Cancer Hospital database." International Journal of Urology : Official Journal of the Japanese Urological Association 22, no. 4 (April 2015): 362-366. Full Text
  - Sourbeer, KN, Howard, LE, Moreira, DM, Amarasekara, HS, Chow, LD, Cockrell, DC, Hanyok, BT, Pratson, CL, Kane, CJ, Terris, MK, Aronson, WJ, Cooperberg, MR, Amling, CL, Hernandez, RK, and Freedland, SJ. "Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: results from the SEARCH database." The Journal of Urology 193, no. 4 (April 2015): 1232-1238. Full Text
  - Vidal, AC, Williams, CD, Allott, EH, Howard, LE, Grant, DJ, McPhail, M, Sourbeer, KN, Hwa, LP, Boffetta, P, Hoyo, C, and Freedland, SJ. "Carbohydrate intake, glycemic index and prostate cancer risk." The Prostate 75, no. 4 (March 2015): 430-439. Full Text
  - Vidal, AC, Howard, LE, Moreira, DM, Castro-Santamaria, R, Andriole, GL, and Freedland, SJ. "Aspirin, NSAIDs, and risk of prostate cancer: results from the REDUCE study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 21, no. 4 (February 2015): 756-762. Full Text
  - Fowke, JH, Howard, L, Andriole, GL, and Freedland, SJ. "Alcohol intake increases high-grade prostate cancer risk among men taking dutasteride in the REDUCE trial." European urology 66, no. 6 (December 2014): 1133-1138. Full Text
  - Vidal, AC, Howard, LE, Moreira, DM, Castro-Santamaria, R, Andriole, GL, and Freedland, SJ. "Obesity increases the risk for high-grade prostate cancer: results from the REDUCE study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23, no. 12 (December 2014): 2936-2942. Full Text
  - Allott, EH, Howard, LE, Cooperberg, MR, Kane, CJ, Aronson, WJ, Terris, MK, Amling, CL, and Freedland, SJ. "Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database." Bju International 114, no. 5 (November 2014): 661-666. Full Text Open Access Copy
  - Allott, EH, Howard, LE, Cooperberg, MR, Kane, CJ, Aronson, WJ, Terris, MK, Amling, CL, and Freedland, SJ. "Serum lipid profile and risk of prostate cancer recurrence: Results from the SEARCH database." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23, no. 11 (November 2014): 2349-2356. Full Text
  - Allott, EH, Howard, LE, Song, H-J, Sourbeer, KN, Koontz, BF, Salama, JK, and Freedland, SJ. "Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology 23, no. 11 (November 2014): 2404-2412. Full Text
  - Ho, T, Howard, LE, Vidal, AC, Gerber, L, Moreira, D, McKeever, M, Andriole, G, Castro-Santamaria, R, and Freedland, SJ. "Smoking and risk of low- and high-grade prostate cancer: results from the REDUCE study." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 20, no. 20 (October 2014): 5331-5338. Full Text
  - Kuchibhatla, M, and Freedland, SJ. "Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: Results from the SEARCH database." Prostate Cancer and Prostatic Diseases 17, no. 1 (March 1, 2014): 91-96. Full Text
  - Moreira, DM, Cooperberg, MR, Howard, LE, Aronson, WJ, Kane, CJ, Terris, MK, Amling, CL, Kuchibhatla, M, and Freedland, SJ. "Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database." Prostate Cancer and Prostatic Diseases 17, no. 1 (March 2014): 91-96. Full Text
  - "Alcohol intake increases high-grade prostate cancer risk among men taking dutasteride in the REDUCE trial." European Urology 66, no. 6 (January 1, 2014): 1133-1138. Full Text
- Conference Papers
  - Klaassen, Z, Singh, AA, Howard, LE, Feng, Z, Trock, B, Terris, MK, Aronson, WJ, Cooperberg, MR, Amling, CL, Kane, CJ, Partin, A, Han, M, and Freedland, SJ. "Is clinical stage T2c prostate cancer an intermediate- or high-risk disease?." May 2015. Full Text
  - McGinley, KF, Sun, X, Howard, LE, Aronson, WJ, Terris, MK, Kane, CJ, Amling, CL, Cooperberg, MR, and Freedland, SJ. "Can Gleason 7 prostate cancer ever be low-risk? Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database." March 2015. Full Text
  - Vidal, AC, Williams, CC, Allott, EH, Howard, LE, Grant, DJ, McPhail, M, Sourbeer, KN, Boffetta, P, Hoyo, C, and Freedland, SJ. "Abstract 1265: Carbohydrate intake, glycemic index and prostate cancer risk." : American Association for Cancer Research (AACR), October 1, 2014. Full Text

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Selected Grants

Selected Publications

Academic Articles

Conference Papers