Scholars@Duke
Lauren Howard

Lauren Howard

Biostatistician, Senior
Biostatistics & Bioinformatics
lauren.howard@duke.edu
DUMC 2717, Durham, NC 27710
2424 Erwin Road, Hock 1 8030, Durham, NC 27705

Selected Publications

Association between beta-blocker atenolol use and prostate cancer upgrading in active surveillance.

Journal Article BJUI compass · November 2024 ObjectivesThe objective of this study is to investigate the association between the use of beta-adrenergic antagonist atenolol and risk of pathologic upgrade in patients on active surveillance, considering growing literature implicating adrenergic ... Full text Cite

Characterization of the Biological Variability of the Angiome Biomarkers over Time in Healthy Subjects.

Journal Article Cancer Epidemiol Biomarkers Prev · October 14, 2024 BACKGROUND: Biomarker analyses are an integral part of cancer research. Despite the intense efforts to identify and characterize biomarkers in cancer patients, little is known regarding the natural variation of biomarkers in healthy populations. Here we co ... Full text Link to item Cite

Primary Care Use and 90-Day Mortality Among Older Adults Undergoing Cancer Surgery.

Journal Article JAMA Surg · October 1, 2024 IMPORTANCE: Multimorbidity and postoperative clinical decompensation are common among older surgical patients with cancer, highlighting the importance of primary care to optimize survival. Little is known about the association between primary care use and ... Full text Link to item Cite

Select black men are potential candidates for prostate hemi-ablation based on radical prostatectomy histopathology for intermediate-risk prostate cancer-a multicenter SEARCH cohort study.

Journal Article Prostate Cancer Prostatic Dis · August 12, 2024 IMPORTANCE AND OBJECTIVE: Partial gland ablation (PGA) is increasingly popular as a treatment for men with intermediate-risk prostate cancer (IR-PCa) to preserve functional outcomes while controlling their cancer. We aimed to determine the impact of race a ... Full text Link to item Cite

Updated 5-year results for short course abiraterone acetate and LHRH agonist for unfavorable intermediate and favorable high-risk prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · February 22, 2024 Combined androgen deprivation therapy (ADT) and radiotherapy (RT) improves outcomes for intermediate and high-risk prostate cancer. Treatment intensification with abiraterone acetate/prednisone (AAP) provides additional benefit for high-risk disease. We pr ... Full text Link to item Cite

Pain and Its Association with Survival for Black and White Individuals with Advanced Prostate Cancer in the United States.

Journal Article Cancer Res Commun · January 8, 2024 UNLABELLED: Bone pain is a well-known quality-of-life detriment for individuals with prostate cancer and is associated with survival. This study expands previous work into racial differences in multiple patient-reported dimensions of pain and the associati ... Full text Link to item Cite

Supplementary Methods S1 from Pain and Its Association with Survival for Black and White Individuals with Advanced Prostate Cancer in the United States

Other · January 8, 2024 <p>Further information guiding the choice of methods and a glossary of technical terms</p> ... Full text Cite

Supplementary Methods S1 from Pain and Its Association with Survival for Black and White Individuals with Advanced Prostate Cancer in the United States

Other · January 8, 2024 <p>Further information guiding the choice of methods and a glossary of technical terms</p> ... Full text Cite

Validation of the prostate cancer comorbidity index in predicting cause-specific mortality in men undergoing radical prostatectomy.

Journal Article Prostate cancer and prostatic diseases · December 2023 PurposeAccurate prediction of competing risks of mortality remains a key component of prostate cancer treatment decision-making. We sought to validate the Prostate Cancer Comorbidity Index (PCCI) score for predicting other-cause mortality (OCM) an ... Full text Cite

Are higher follicle-stimulating hormone levels before androgen deprivation therapy for prostate cancer associated with oncological and cardiac outcomes and overall survival?-a population-level analysis.

Journal Article Transl Androl Urol · October 31, 2023 BACKGROUND: Androgen deprivation therapy (ADT), commonly delivered via a luteinizing hormone-releasing hormone (LHRH) agonist, is the standard treatment for advanced prostate cancer (PC). While quite effective, it has been associated with an increased risk ... Full text Link to item Cite

Exposure to Agent Orange and Risk of Bladder Cancer Among US Veterans.

Journal Article JAMA network open · June 2023 ImportanceTo date, limited data exist regarding the association between Agent Orange and bladder cancer, and the Institute of Medicine concluded that the association between exposure to Agent Orange and bladder cancer outcomes is an area of needed ... Full text Cite

Is time to castration resistant prostate cancer a potential intermediate end-point for time to metastasis among men initiating androgen deprivation therapy for non-metastatic prostate cancer with rapid PSA doubling time (<9 months)?

Journal Article Prostate Cancer Prostatic Dis · March 2023 PURPOSE: Metastasis-free survival (MFS) is a surrogate for overall survival (OS) in men with non-metastatic castration-resistant prostate cancer (CRPC), but this endpoint may take years to develop in men with non-metastatic castrate-sensitive disease. The ... Full text Link to item Cite

Metabolic syndrome is associated with aggressive prostate cancer regardless of race.

Journal Article Cancer causes & control : CCC · March 2023 PurposeRecent meta-analyses suggest the Metabolic Syndrome (MS) increases high-grade prostate cancer (PC), although studies are inconsistent and few black men were included. We investigated MS and PC diagnosis in black and white men undergoing pro ... Full text Cite

Weight loss via a low-carbohydrate diet improved the intestinal permeability marker, zonulin, in prostate cancer patients.

Journal Article Ann Med · December 2022 BACKGROUND: Accumulating evidence suggest that gut microbiota may impact urologic health including prostate cancer (PC), potentially via affecting intestinal permeability (IP). Studies have indicated that disrupted IP may be improved by healthy diets and w ... Full text Link to item Cite

Are higher pre-diagnosis follicle stimulating hormone levels associated with long-term prostate cancer risk?

Journal Article Prostate · December 2022 BACKGROUND: Follicle stimulating hormone (FSH) is a pituitary hormone that helps regulate testosterone homeostasis. Although it is generally accepted that FSH levels increase with LHRH-agonist therapy for prostate cancer (PC), the specific impact of FSH le ... Full text Link to item Cite

Identification of Patients With Metastatic Prostate Cancer With Natural Language Processing and Machine Learning.

Journal Article JCO clinical cancer informatics · October 2022 PurposeUnderstanding treatment patterns and effectiveness for patients with metastatic prostate cancer (mPCa) is dependent on accurate assessment of metastatic status. The objective was to develop a natural language processing (NLP) model for iden ... Full text Cite

Racial differences in circulating mitochondria-derived peptides may contribute to prostate cancer health disparities.

Journal Article The Prostate · September 2022 IntroductionThe mitochondrial genome has small open reading frames (sORF) which produce measurable mitochondrial-derived peptides (MDPs), including humanin, SHLP2, and MOTS-c. Previously, among men undergoing prostate biopsy, we found higher serum ... Full text Cite

Reply by Authors.

Journal Article Urol Pract · September 2022 Full text Link to item Cite

Radium-223 Utilization Patterns and Outcomes in Clinical Practice.

Journal Article Urol Pract · September 2022 INTRODUCTION: Radium-223 was approved for metastatic castration-resistant prostate cancer based on the ALSYMPCA trial. We characterize radium-223 treatment patterns and overall survival (OS) in a large equal access health system. METHODS: We identified all ... Full text Link to item Cite

Phase I Study of Lenvatinib and Capecitabine with External Radiation Therapy in Locally Advanced Rectal Adenocarcinoma.

Journal Article Oncologist · August 5, 2022 BACKGROUND: Neoadjuvant chemoradiation with fluoropyrimidine followed by surgery and adjuvant chemotherapy has been the standard treatment of locally advanced stages II and III rectal cancer for many years. There is a high risk for disease recurrence; ther ... Full text Link to item Cite

Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer.

Journal Article Prostate · May 2022 BACKGROUND: In preclinical models of prostate cancer (PC), disulfiram (DSF) reduced tumor growth only when co-administered with copper (Cu), and Cu uptake in tumors is partially regulated by androgen-receptor signaling. However, prior trials of DSF in PC u ... Full text Link to item Cite

A phase 2 trial of avelumab in men with aggressive-variant or neuroendocrine prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · April 2022 BACKGROUND: Men with progressive neuroendocrine or aggressive-variant metastatic prostate cancer (NEPC/AVPC) have a poor prognosis and limited treatment options, and immunotherapy has not been tested in such patients. METHODS: We conducted an open label si ... Full text Link to item Cite

Serum metabolomic analysis of men on a low-carbohydrate diet for biochemically recurrent prostate cancer reveals the potential role of ketogenesis to slow tumor growth: a secondary analysis of the CAPS2 diet trial.

Journal Article Prostate Cancer Prostatic Dis · April 2022 BACKGROUND: Systemic treatments for prostate cancer (PC) have significant side effects. Thus, newer alternatives with fewer side effects are urgently needed. Animal and human studies suggest the therapeutic potential of low carbohydrate diet (LCD) for PC. ... Full text Open Access Link to item Cite

Association between Delay to Radical Prostatectomy and Clinically Meaningful Outcomes among Patients with Intermediate and High-Risk Localized Prostate Cancer.

Journal Article The Journal of urology · March 2022 PurposeThere are limited data regarding the effect of treatment delays on important long-term outcomes among men with intermediate/high-risk prostate cancer (PC).Materials and methodsWe identified 3,962 men with intermediate/high-risk dis ... Full text Cite

Cabozantinib with or without Panitumumab for RAS wild-type metastatic colorectal cancer: impact of MET amplification on clinical outcomes and circulating biomarkers.

Journal Article Cancer Chemother Pharmacol · March 2022 PURPOSE: Acquired resistance to EGFR inhibitors in metastatic colorectal cancer (mCRC) remains a hurdle for effective treatment. MET amplification has been indicated as a driver of acquired resistance. Clinical activity has been demonstrated for the combin ... Full text Link to item Cite

Red Blood Cell Distribution Width Is Associated with All-cause Mortality but Not Adverse Cancer-specific Outcomes in Men with Clinically Localized Prostate Cancer Treated with Radical Prostatectomy: Findings Based on a Multicenter Shared Equal Access Regional Cancer Hospital Registry.

Journal Article Eur Urol Open Sci · March 2022 BACKGROUND: Recent reports with a small number of patients showed an association of red blood cell distribution width (RDW) with prostate cancer (PCa) progression. OBJECTIVE: To investigate whether preoperative RDW can serve as a prognostic marker in patie ... Full text Link to item Cite

Non-canonical role of Hippo tumor suppressor serine/threonine kinase 3 STK3 in prostate cancer.

Journal Article Mol Ther · January 5, 2022 Serine/threonine kinase 3 (STK3) is an essential member of the highly conserved Hippo tumor suppressor pathway that regulates Yes-associated protein 1 (YAP1) and TAZ. STK3 and its paralog STK4 initiate a phosphorylation cascade that regulates YAP1/TAZ inhi ... Full text Link to item Cite

Context-Based Identification of Muscle Invasion Status in Patients With Bladder Cancer Using Natural Language Processing.

Journal Article JCO clinical cancer informatics · January 2022 PurposeMortality from bladder cancer (BC) increases exponentially once it invades the muscle, with inherent challenges delineating at the population level. We sought to develop and validate a natural language processing (NLP) model for automatical ... Full text Cite

Low Carbohydrate Diets and Estimated Cardiovascular and Metabolic Syndrome Risk in Prostate Cancer.

Journal Article J Urol · December 2021 PURPOSE: A low carbohydrate diet (LCD) was shown to suggestively slow prostate cancer (PC) growth. In noncancer patients, LCDs improve metabolic syndrome (MetS) without weight loss. However, concerns about negative impact on cardiovascular disease (CVD) ri ... Full text Link to item Cite

The impact of the social construct of race on outcomes among bacille Calmette-Guérin-treated patients with high-risk non-muscle-invasive bladder cancer in an equal-access setting.

Journal Article Cancer · November 1, 2021 BACKGROUND: The objective of this study was to describe bladder cancer outcomes as a function of race among patients with high-risk non-muscle-invasive bladder cancer (NMIBC) in an equal-access setting. METHODS: A total of 412 patients with high-risk NMIBC ... Full text Link to item Cite

Urological Oncology: Prostate Cancer.

Journal Article The Journal of urology · November 2021 Full text Cite

Dutasteride Improves Nocturia but Does Not Lead to Better Sleep: Results from the REDUCE Clinical Trial.

Journal Article The Journal of urology · June 2021 PurposeIn men, complaints of nocturia causing poor sleep are often attributed to benign prostatic hyperplasia and treated with benign prostatic hyperplasia medications. We assessed whether treating lower urinary tract symptoms with dutasteride alt ... Full text Cite

Time Trends in Use of Radical Prostatectomy by Tumor Risk and Life Expectancy in a National Veterans Affairs Cohort.

Journal Article JAMA network open · June 2021 ImportanceGuidelines endorse using tumor risk and life expectancy (LE) to select appropriate candidates for radical prostatectomy (RP), recommending against treatment of most low-risk tumors and men with limited LE.ObjectiveTo investigate ... Full text Cite

Diabetes and Prostate Cancer Outcomes in Obese and Nonobese Men After Radical Prostatectomy.

Journal Article JNCI cancer spectrum · June 2021 BackgroundThe link between diabetes and prostate cancer progression is poorly understood and complicated by obesity. We investigated associations between diabetes and prostate cancer-specific mortality (PCSM), castrate-resistant prostate cancer (C ... Full text Cite

Safety of concomitant therapy with radium-223 and abiraterone or enzalutamide in a real-world population.

Journal Article Prostate · May 2021 BACKGROUND: Real-world utilization and outcomes of combination therapy for men with metastatic castrate-resistant prostate cancer (mCRPC) are largely unknown. We evaluated the overall survival (OS) and skeletal-related events (SREs) among men who received ... Full text Link to item Cite

Family history of prostate cancer and prostate tumor aggressiveness in black and non-black men;results from an equal access biopsy study.

Journal Article Cancer causes & control : CCC · April 2021 PurposeTo test for racial differences in associations between family history (FH) of prostate cancer (PC) and prostate cancer aggressiveness in a racially diverse equal access population undergoing prostate biopsy.Subjects/patients and methods ... Full text Cite

Partial Validation of the Sleep Health Construct in the Medical Outcomes Study Sleep Questionnaire.

Journal Article Journal of clinical psychology in medical settings · March 2021 Sleep health is postulated as a multi-dimensional construct comprised of sleepiness/alertness, timing, duration, efficiency, and satisfaction. New questionnaires for its measurement have been proposed. We performed secondary data analyses and analyzed resp ... Full text Cite

Do Hispanic Men Have Worse Outcomes After Radical Prostatectomy? Results From SEARCH.

Journal Article Urology · March 2021 ObjectiveTo examine the associations between ethnicity and outcomes after radical prostatectomy (RP) among Hispanics. While non-Hispanic Black men have worse prostate cancer (PC) outcomes, there are limited data on outcomes of Hispanic men, especi ... Full text Cite

Estimated Costs and Long-term Outcomes of Patients With High-Risk Non-Muscle-Invasive Bladder Cancer Treated With Bacillus Calmette-Guérin in the Veterans Affairs Health System.

Journal Article JAMA network open · March 2021 ImportanceManagement of high-risk non-muscle-invasive bladder cancer (NMIBC) represents a clinical challenge due to high failure rates despite prior bacillus Calmette-Guérin (BCG) therapy.ObjectiveTo describe real-world patient characteri ... Full text Cite

The Impact of Comorbidity and Age on Timing of Androgen Deprivation Therapy in Men with Biochemical Recurrence after Radical Prostatectomy.

Journal Article Urology practice · March 2021 IntroductionOlder men with major comorbidities have higher risks of morbidity and mortality from androgen deprivation therapy, and the benefits of immediate androgen deprivation therapy after biochemical recurrence in these men are unclear. We ass ... Full text Cite

Monocyte counts and prostate cancer outcomes in white and black men: results from the SEARCH database.

Journal Article Cancer causes & control : CCC · February 2021 PurposeCirculating inflammatory markers may predict prostate cancer (PC) outcomes. For example, a recent study showed that higher peripheral blood monocyte counts were associated with aggressive PC in Asian men undergoing radical prostatectomy (RP ... Full text Cite

Sleep quality and prostate cancer aggressiveness: Results from the REDUCE trial.

Journal Article The Prostate · November 2020 BackgroundDisrupted sleep has been associated with increased risk of certain cancers. Little data exist in prostate cancer. We tested the association between sleep quality and prostate cancer diagnosis overall and by tumor grade in the Reduction b ... Full text Cite

Obese men undergoing radical prostatectomy: Is robotic or retropubic better to limit positive surgical margins? Results from SEARCH.

Journal Article International journal of urology : official journal of the Japanese Urological Association · October 2020 ObjectivesTo evaluate the association between obesity and positive surgical margins in patients undergoing retropubic radical prostatectomy versus robotic-assisted laparoscopic prostatectomy.MethodsWe retrospectively reviewed the data of ... Full text Cite

Abdominal and pelvic adipose tissue distribution and risk of prostate cancer recurrence after radiation therapy.

Journal Article Prostate · October 2020 BACKGROUND: Fat distribution varies between individuals of similar body mass index (BMI). We hypothesized that visceral obesity is more strongly associated with poor prostate cancer outcomes than overall obesity defined by BMI. MATERIALS AND METHODS: We qu ... Full text Link to item Cite

Validation of a genomic classifier for prediction of metastasis and prostate cancer-specific mortality in African-American men following radical prostatectomy in an equal access healthcare setting.

Journal Article Prostate cancer and prostatic diseases · September 2020 BackgroundThe Decipher 22-gene genomic classifier (GC) may help in post-radical prostatectomy (RP) decision making given its superior prognostic performance over clinicopathologic variables alone. However, most studies evaluating the GC have had a ... Full text Cite

Competing Risks of Mortality among Men with Biochemical Recurrence after Radical Prostatectomy.

Journal Article The Journal of urology · September 2020 PurposeMen with biochemical recurrence after radical prostatectomy need information on competing risks of mortality to inform prognosis and guide treatment. We quantified the risk of prostate cancer metastasis and mortality, and other cause mortal ... Full text Cite

Obesity, race, and long-term prostate cancer outcomes.

Journal Article Cancer · August 2020 BackgroundThe authors previously found that obesity was linked with prostate cancer (PC)-specific mortality (PCSM) among men who underwent radical prostatectomy (RP). Herein, in a larger RP cohort, the authors investigated whether the association ... Full text Cite

Race does not predict skeletal-related events and all-cause mortality in men with castration-resistant prostate cancer.

Journal Article Cancer · July 2020 BackgroundThe impact of race on prostate cancer skeletal-related events (SREs) remains understudied. In the current study, the authors tested the impact of race on time to SREs and overall survival in men with newly diagnosed, bone metastatic cast ... Full text Cite

A Randomized Controlled Trial of a 6-Month Low-Carbohydrate Intervention on Disease Progression in Men with Recurrent Prostate Cancer: Carbohydrate and Prostate Study 2 (CAPS2).

Journal Article Clin Cancer Res · June 15, 2020 PURPOSE: Both weight loss and low-carbohydrate diets (LCD) without weight loss prolong survival in prostate cancer models. Few human trials have tested weight loss or LCD on prostate cancer. EXPERIMENTAL DESIGN: We conducted a multi-site randomized 6-month ... Full text Link to item Cite

Soluble Endoglin (sCD105) as a Novel Biomarker for Detecting Aggressive Prostate Cancer.

Journal Article Anticancer research · March 2020 Background/aimWe have previously found elevated levels of endoglin (CD105) in the prostate cancer (PC) tissue of men with poor prognosis, compared to men with indolent disease. Herein, we examined whether plasma levels of the soluble form of CD105 ... Full text Cite

Statin use and longitudinal changes in prostate volume; results from the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial.

Journal Article BJU international · February 2020 ObjectiveTo test the association between statin use and prostate volume (PV) change over time using data from the REduction by DUtasteride of prostate Cancer Events (REDUCE) trial, a 4-year randomised controlled trial testing dutasteride for prost ... Full text Cite

Racial Discrepancies in Overall Survival among Men Treated with 223Radium.

Journal Article J Urol · February 2020 PURPOSE: Several recent studies on metastatic castration resistant prostate cancer demonstrated improved overall survival in black vs white men. 223Radium is Food and Drug Administration approved for metastatic castration resistant prostate cancer based on ... Full text Link to item Cite

Serum Lipids prior to Starting Androgen Deprivation Therapy and Risk of Castration Resistant Prostate Cancer and Metastasis: Results from the SEARCH Database.

Journal Article The Journal of urology · January 2020 PurposeWe tested the association of serum lipid levels prior to androgen deprivation therapy with the risk of castration resistant prostate cancer and metastasis.Materials and methodsWe identified 302 men in the SEARCH (Shared Equal Acces ... Full text Cite

Reply by Authors.

Journal Article The Journal of urology · January 2020 Full text Cite

MEK-ERK signaling is a therapeutic target in metastatic castration resistant prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · December 2019 BACKGROUND: Metastatic castration resistant prostate cancer (mCRPC) is incurable and progression after drugs that target the androgen receptor-signaling axis is inevitable. Thus, there is an urgent need to develop more effective treatments beyond hormonal ... Full text Link to item Cite

Dietary inflammatory index (DII) and risk of prostate cancer in a case-control study among Black and White US Veteran men.

Journal Article Prostate Cancer Prostatic Dis · December 2019 BACKGROUND: We hypothesized a pro-inflammatory diet would be associated with higher prostate cancer (PC) risk. METHODS: We prospectively recruited incident PC cases (n = 254) and controls (n = 328) at the Durham Veteran Affairs, from 2007 to 2018. From a s ... Full text Link to item Cite

Validity of the National Death Index to ascertain the date and cause of death in men having undergone prostatectomy for prostate cancer.

Journal Article Prostate cancer and prostatic diseases · December 2019 BackgroundThe National Death Index (NDI) is a centralized database containing information from death certificates that are frequently referenced by health and medical investigators to ascertain vital statistics. Yet, it commonly includes misclassi ... Full text Cite

Predictors of skeletal-related events and mortality in men with metastatic, castration-resistant prostate cancer: Results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.

Journal Article Cancer · November 2019 BackgroundAlthough skeletal-related events (SREs) are linked with a reduced quality of life and worse outcomes, to the authors' knowledge the factors that predict SREs are minimally understood. The objective of the current study was to identify pr ... Full text Cite

Salvage Radiotherapy for Recurrent Prostate Cancer: Can the Prognostic Grade Group System Inform Treatment Timing?

Journal Article Clin Genitourin Cancer · October 2019 PURPOSE: In order to better time salvage radiotherapy (SRT) for post-radical prostatectomy biochemical failure, we examined the association between pre-SRT prostate-specific antigen (PSA) and PSA control as a function of the new prognostic grade group (PGG ... Full text Link to item Cite

Natural killer cell activity and prostate cancer risk in veteran men undergoing prostate biopsy.

Journal Article Cancer epidemiology · October 2019 BackgroundA previous pilot study found that men with a positive prostate biopsy had low numbers of circulating natural killer (NK) cells, compared to biopsy negative men.MethodsTo confirm these data, we analyzed differences in NK cells fr ... Full text Cite

A lifestyle intervention of weight loss via a low-carbohydrate diet plus walking to reduce metabolic disturbances caused by androgen deprivation therapy among prostate cancer patients: carbohydrate and prostate study 1 (CAPS1) randomized controlled trial.

Journal Article Prostate Cancer Prostatic Dis · September 2019 PURPOSE: The objective of this study was to test a low-carbohydrate diet (LCD) plus walking to reduce androgen deprivation therapy (ADT)-induced metabolic disturbances. MATERIALS AND METHODS: This randomized multi-center trial of prostate cancer (PCa) pati ... Full text Open Access Link to item Cite

Influence of African American race on the association between preoperative biopsy grade group and adverse histopathologic features of radical prostatectomy.

Journal Article Cancer · September 1, 2019 BACKGROUND: The current study was performed to evaluate the influence of race on the association between biopsy grade group (GrGp) and the risk of detectable prostate-specific antigen (PSA) and adverse histopathological outcomes after radical prostatectomy ... Full text Link to item Cite

The misdiagnosis of interstitial cystitis/bladder pain syndrome in a VA population.

Journal Article Neurourology and urodynamics · September 2019 AimsThe complexity of Interstitial Cystitis/bladder Pain Syndrome (IC/BPS) has led to a great deal of uncertainty around the diagnosis and prevalence of the condition. Under the hypothesis that IC/BPS is frequently misdiagnosed, we sought to asses ... Full text Cite

Poorly controlled diabetes increases the risk of metastases and castration-resistant prostate cancer in men undergoing radical prostatectomy: Results from the SEARCH database.

Journal Article Cancer · August 2019 BackgroundAlthough diabetes is inversely related to prostate cancer (PC) risk, to the authors' knowledge the impact of glycemic control on PC progression is unknown. In the current study, the authors tested the association between hemoglobin A1c ( ... Full text Cite

Obesity, risk of biochemical recurrence, and prostate-specific antigen doubling time after radical prostatectomy: results from the SEARCH database.

Journal Article BJU international · July 2019 ObjectivesTo examine the association between body mass index (BMI) and aggressive biochemical recurrence (BCR) using the Shared Equal Access Regional Cancer Hospital (SEARCH) database.Material and methodsWe identified 4123 men with comple ... Full text Cite

Practice patterns and outcomes of equivocal bone scans for patients with castration-resistant prostate cancer: Results from SEARCH.

Journal Article Asian journal of urology · July 2019 ObjectiveTo review follow-up imaging after equivocal bone scans in men with castration resistant prostate cancer (CRPC) and examine the characteristics of equivocal bone scans that are associated with positive follow-up imaging.MethodsWe ... Full text Cite

Impact of age, comorbidity, and PSA doubling time on long-term competing risks for mortality among men with non-metastatic castration-resistant prostate cancer.

Journal Article Prostate cancer and prostatic diseases · May 2019 BackgroundUnderstanding competing risks for mortality is critical in determining prognosis among men with non-metastatic castration-resistant prostate cancer (nmCRPC), a disease state that often affects older men and has substantial heterogeneity ... Full text Cite

Blood and dietary magnesium levels are not linked with lower prostate cancer risk in black or white men.

Journal Article Cancer letters · May 2019 Recent studies suggest a diet low in dietary magnesium intake or lower blood magnesium levels is linked with increased prostate cancer risk. This study investigates the race-specific link between blood magnesium and calcium levels, or dietary magnesium int ... Full text Cite

Socioeconomic status, race, and long-term outcomes after radical prostatectomy in an equal access health system: Results from the SEARCH database.

Journal Article Urologic oncology · April 2019 IntroductionWe previously found racial differences in biochemical recurrence (BCR) after radical prostatectomy (RP) persisted after adjusting for socioeconomic status (SES) while SES did not predict BCR. The impact on long-term prostate cancer (PC ... Full text Cite

Nocturia and associated mortality: observational data from the REDUCE trial.

Journal Article Prostate cancer and prostatic diseases · March 2019 BackgroundNocturia (voids arising from sleep) is a ubiquitous phenomenon reflecting many diverse conditions but whether it has significance in its own right remains uncertain. We examined whether nocturia was an independent risk factor for mortali ... Full text Cite

First-year weight loss with androgen-deprivation therapy increases risks of prostate cancer progression and prostate cancer-specific mortality: results from SEARCH.

Journal Article Cancer Causes Control · March 2019 PURPOSE: We aimed to study the associations between androgen-deprivation therapy (ADT)-induced weight changes and prostate cancer (PC) progression and mortality in men who had undergone radical prostatectomy (RP). METHODS: Data from the Shared Equal Access ... Full text Link to item Cite

Statins are Associated With Increased Biochemical Recurrence After Radical Prostatectomy in Diabetic Men but no Association was Seen in Men also Taking Metformin: Results From the SEARCH Database.

Journal Article Clin Genitourin Cancer · February 2019 PURPOSE: To investigate the preoperative use of combination metformin and statin versus monotherapy on biochemical recurrence (BCR) after radical prostatectomy (RP) in diabetic men. PATIENTS AND METHODS: Data of 843 diabetic men who underwent RP were strat ... Full text Link to item Cite

Does race predict the development of metastases in men who receive androgen-deprivation therapy for a biochemical recurrence after radical prostatectomy?

Journal Article Cancer · February 2019 BackgroundIn this study among men who underwent radical prostatectomy (RP), African American men (AAM) were 28% more likely to develop recurrent disease compared with Caucasian men (CM). However, among those who had nonmetastatic, castration-resis ... Full text Cite

Interplay between exercise and BMI; results from an equal access, racially diverse biopsy study.

Journal Article Cancer causes & control : CCC · January 2019 PurposeIt is unclear if exercise and BMI interact to influence prostate cancer (PC) risk. We hypothesized BMI is linked with increased aggressive PC risk but this link will be attenuated with increased exercise.MethodsMen undergoing prost ... Full text Cite

Both acute and chronic inflammation are associated with less perineural invasion in men with prostate cancer on repeat biopsy

Journal Article BJU International · January 2019 ObjectivesTo evaluate the association between acute and chronic inflammation with the presence of perineural invasion (PNI) in prostate biopsies positi ... Full text Cite

Impact of prior local therapy on overall survival in men with metastatic castration-resistant prostate cancer: Results from Shared Equal Access Regional Cancer Hospital.

Journal Article International journal of urology : official journal of the Japanese Urological Association · December 2018 ObjectivesTo evaluate the impact of previous local treatment on survival in men with newly diagnosed metastatic castration-resistant prostate cancer.MethodsWe carried out a retrospective study of patients newly diagnosed with metastatic c ... Full text Cite

Radical prostatectomy and the effect of close surgical margins: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.

Journal Article BJU international · October 2018 ObjectiveTo evaluate biochemical recurrence (BCR) patterns amongst men undergoing radical prostatectomy (RP) with specimens having negative (NSM), positive (PSM), and close surgical margins (CSM) from the Shared Equal Access Regional Cancer Hospit ... Full text Cite

Prostate Specific Antigen Density as a Predictor of Clinically Significant Prostate Cancer When the Prostate Specific Antigen is in the Diagnostic Gray Zone: Defining the Optimum Cutoff Point Stratified by Race and Body Mass Index.

Journal Article J Urol · October 2018 PURPOSE: We assessed the predictive value of prostate specific antigen density to detect clinically significant prostate cancer, defined as prostate cancer grade group 2 or greater, in a series of men undergoing prostate biopsy with prostate specific antig ... Full text Link to item Cite

Early-Life Alcohol Intake and High-Grade Prostate Cancer: Results from an Equal-Access, Racially Diverse Biopsy Cohort.

Journal Article Cancer prevention research (Philadelphia, Pa.) · October 2018 Epidemiologic evidence for an association between alcohol and prostate cancer is mixed. Moreover, there is a lack of research investigating early-life alcohol intake as a risk factor for either overall or high-grade prostate cancer. We examined lifetime al ... Full text Cite

Obese patients with castration-resistant prostate cancer may be at a lower risk of all-cause mortality: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.

Journal Article BJU international · July 2018 ObjectiveTo assess whether obesity is associated with progression to metastasis, prostate cancer-specific mortality (PCSM), and all-cause mortality (ACM), in patients with non-metastatic castration-resistant prostate cancer (non-mCRPC). At the pop ... Full text Cite

Geographic Differences in Baseline Prostate Inflammation and Relationship with Subsequent Prostate Cancer Risk: Results from the Multinational REDUCE Trial.

Journal Article Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · July 2018 Background: Prostate cancer incidence rates vary 25-fold worldwide. Differences in PSA screening are largely, but not entirely, responsible. We examined geographic differences in prevalence of histologic prostate inflammation and subsequent prostate ... Full text Cite

Is Ki67 prognostic for aggressive prostate cancer? A multicenter real-world study.

Journal Article Biomark Med · July 2018 AIM: To test if Ki67 expression is prognostic for biochemical recurrence (BCR) after radical prostatectomy (RP). METHODS: Ki67 immunohistochemistry was performed on tissue microarrays constructed from specimens obtained from 464 men undergoing RP at the Du ... Full text Link to item Cite

Serum cholesterol and risk of high-grade prostate cancer: results from the REDUCE study.

Journal Article Prostate cancer and prostatic diseases · June 2018 BackgroundEpidemiologic evidence for a serum cholesterol-prostate cancer link is mixed. Prostate-specific antigen (PSA) is positively correlated with cholesterol, potentially increasing PSA-driven biopsy recommendations in men with high cholestero ... Full text Cite

Neutrophil, lymphocyte and platelet counts, and risk of prostate cancer outcomes in white and black men: results from the SEARCH database.

Journal Article Cancer causes & control : CCC · June 2018 PurposeSystemic inflammation, as measured by C-reactive protein, has been linked with poor prostate cancer (PC) outcomes, predominantly in white men. Whether other immune measures like white blood cell counts are correlated with PC progression and ... Full text Cite

PSA predicts development of incident lower urinary tract symptoms: results from the REDUCE study.

Journal Article Prostate cancer and prostatic diseases · June 2018 BackgroundThe relationship between baseline prostate-specific antigen (PSA) and development of lower urinary tract symptoms (LUTS) in asymptomatic and mildly symptomatic men is unclear. We sought to determine if PSA predicts incident LUTS in these ... Full text Cite

First postoperative PSA is associated with outcomes in patients with node positive prostate cancer: Results from the SEARCH database.

Journal Article Urologic oncology · May 2018 ObjectiveTo analyze factors associated with metastases, prostate cancer-specific mortality, and all-cause mortality in pN1 patients.Materials and methodsWe analyzed 3,642 radical prostatectomy patients within the Shared Equal Access Regio ... Full text Cite

Does Early Prostate Specific Antigen Doubling Time after Radical Prostatectomy, Calculated Prior to Prostate Specific Antigen Recurrence, Correlate with Prostate Cancer Outcomes? A Report from the SEARCH Database Group.

Journal Article The Journal of urology · March 2018 PurposeShort prostate specific antigen doubling time following recurrence after radical prostatectomy portends a poor prognosis. Prostate specific antigen doubling time is traditionally calculated using prostate specific antigen values 0.2 ng/ml o ... Full text Cite

Sleep Problems are Associated with Development and Progression of Lower Urinary Tract Symptoms: Results from REDUCE.

Journal Article The Journal of urology · February 2018 PurposeAlthough lower urinary tract symptoms and sleep problems often develop together, to our knowledge it is unknown whether sleep disturbances are linked to lower urinary tract symptoms development and progression. As measured by the 6-item MOS ... Full text Cite

Biopsy Detected Gleason Pattern 5 is Associated with Recurrence, Metastasis and Mortality in a Cohort of Men with High Risk Prostate Cancer.

Journal Article The Journal of urology · December 2017 PurposeWe evaluated the relative risk of biochemical recurrence, metastasis and death from prostate cancer contributed by biopsy Gleason pattern 5 among men at high risk with Gleason 8-10 disease in the SEARCH (Shared Equal Access Regional Cancer ... Full text Cite

Modified risk stratification grouping using standard clinical and biopsy information for patients undergoing radical prostatectomy: Results from SEARCH.

Journal Article The Prostate · December 2017 IntroductionProstate cancer is a heterogeneous disease, and risk stratification systems have been proposed to guide treatment decisions. However, significant heterogeneity remains for those with unfavorable-risk disease.MethodsThis study ... Full text Cite

Thresholds for PSA doubling time in men with non-metastatic castration-resistant prostate cancer.

Journal Article BJU international · November 2017 ObjectivesTo examine whether prostate-specific antigen doubling time (PSADT) correlates with metastases, all-cause mortality (ACM), and prostate cancer-specific mortality (PCSM) and to identify PSADT thresholds that can be used clinically for risk ... Full text Cite

Race and risk of metastases and survival after radical prostatectomy: Results from the SEARCH database.

Journal Article Cancer · November 2017 BackgroundBlack race is associated with prostate cancer (PC) diagnosis and poor outcome. Previously, the authors reported that black men undergoing radical prostatectomy (RP) in equal-access hospitals had an increased risk of biochemical disease r ... Full text Cite

Validation of the 2015 prostate cancer grade groups for predicting long-term oncologic outcomes in a shared equal-access health system.

Journal Article Cancer · November 1, 2017 BACKGROUND: A 5-tier prognostic grade group (GG) system was enacted to simplify the risk stratification of patients with prostate cancer in which Gleason scores of ≤6, 3 + 4, 4 + 3, 8, and 9 or 10 are considered GG 1 through 5, respectively. The authors in ... Full text Link to item Cite

Low circulating levels of the mitochondrial-peptide hormone SHLP2: novel biomarker for prostate cancer risk.

Journal Article Oncotarget · November 2017 ContextMitochondrial DNA mutations and dysfunction are associated with prostate cancer (PCa). Small humanin-like peptide-2 (SHLP2) is a novel mitochondrial-encoded peptide and an important mitochondrial retrograde signaling molecule.Objective< ... Full text Cite

Timing of Prostate-specific Antigen Nadir After Radical Prostatectomy and Risk of Biochemical Recurrence.

Journal Article Urology · October 2017 ObjectiveTo evaluate the association between the prostate-specific antigen (PSA) nadir level and the time to nadir (TTN) with biochemical recurrence (BCR) risk after radical prostatectomy (RP) in the Shared Equal-Access Research Cancer Hospital (S ... Full text Cite

In Men with Castration-Resistant Prostate Cancer, Visceral Metastases Predict Shorter Overall Survival: What Predicts Visceral Metastases? Results from the SEARCH Database.

Journal Article European urology focus · October 2017 BackgroundAlthough visceral metastases (VMs) are widely recognized to portend worse prognoses compared with bone and lymph metastases in men with metastatic castration-resistant prostate cancer (mCRPC), little is known about what predicts VMs and ... Full text Cite

Angiotensin receptor signaling and prostate tumor growth in mice.

Journal Article J Exp Ther Oncol · September 2017 The renin-angiotensin system, through its type 1 and type 2 angiotensin receptors (AT1R and AT2R, respectively) may have a role in prostate cancer. The objective of this pilot study was to explore that potential role by determining whether the AT1R blocker ... Link to item Cite

Does Peak Urine Flow Rate Predict the Development of Incident Lower Urinary Tract Symptoms in Men with Mild to No Current Symptoms? Results from REDUCE.

Journal Article The Journal of urology · September 2017 PurposeWe determined whether decreased peak urine flow is associated with future incident lower urinary tract symptoms in men with mild to no lower urinary tract symptoms.Materials and methodsOur population consisted of 3,140 men from the ... Full text Cite

Racial differences in prostate inflammation: results from the REDUCE study.

Journal Article Oncotarget · September 2017 Prostate cancer (PC) risk differs between races, and we previously showed prostate inflammation in benign prostate tissue was linked with a lower future PC risk. However, whether prostate tissue inflammation varies by race is unknown. We analyzed baseline ... Full text Cite

Characterization of a "low-risk" cohort of grade group 2 prostate cancer patients: Results from the Shared Equal Access Regional Cancer Hospital database.

Journal Article International journal of urology : official journal of the Japanese Urological Association · August 2017 ObjectivesTo examine if there is a subset of men with grade group 2 prostate cancer who could be potential candidates for active surveillance.MethodsWe used the Shared Equal Access Regional Cancer Hospital database to identify 776 men und ... Full text Cite

Predictors of operative time during radical retropubic prostatectomy and robot-assisted laparoscopic prostatectomy.

Journal Article International journal of urology : official journal of the Japanese Urological Association · August 2017 ObjectivesTo better predict operative time using patient/surgical characteristics among men undergoing radical retropubic prostatectomy or robot-assisted laparoscopic prostatectomy in order to achieve more efficient operative scheduling and potent ... Full text Cite

Response to Editorial Comment to Predictors of operative time during radical retropubic prostatectomy and robot-assisted laparoscopic prostatectomy.

Journal Article International journal of urology : official journal of the Japanese Urological Association · August 2017 Full text Cite

UDP-glucuronosyltransferases and biochemical recurrence in prostate cancer progression.

Journal Article BMC Cancer · July 3, 2017 BACKGROUND: Uridine 5'-diphosphate-glucuronosyltransferase 2B (UGT2B) genes code for enzymes that catalyze the clearance of testosterone, dihydrotestosterone (DHT), and DHT metabolites in the prostate basal and luminal tissue. The expression of the UGT2B15 ... Full text Link to item Cite

Is Body Mass Index the Best Adiposity Measure for Prostate Cancer Risk? Results From a Veterans Affairs Biopsy Cohort.

Journal Article Urology · July 2017 ObjectiveTo test multiple adiposity measures and prostate cancer (PC) risk in men undergoing prostate biopsy. We hypothesized that body mass index (BMI), body fat, and waist circumference would be highly correlated, and all would be associated wit ... Full text Cite

Statin Use, Serum Lipids, and Prostate Inflammation in Men with a Negative Prostate Biopsy: Results from the REDUCE Trial.

Journal Article Cancer prevention research (Philadelphia, Pa.) · June 2017 Statin use is associated with lower advanced prostate cancer risk. In addition to cholesterol lowering, statins have systemic anti-inflammatory properties. However, their effect on histologic prostate inflammation is not well understood, particularly among ... Full text Cite

Factors predicting skeletal-related events in patients with bone metastatic castration-resistant prostate cancer.

Journal Article Cancer · May 2017 BackgroundSkeletal-related events (SREs) are common complications of bone metastatic castration-resistant prostate cancer (mCRPC). To the authors' knowledge, there are limited data regarding which factors predict SREs. The authors identified risk ... Full text Cite

Association of Obesity-Related Hemodilution of Prostate-Specific Antigen, Dihydrotestosterone, and Testosterone.

Journal Article The Prostate · April 2017 BackgroundProstate-specific antigen (PSA) hemodilution is the leading theory for lower PSA values in obese men. However, testosterone and dihydrotestosterone (DHT), which are necessary for PSA production, are reduced in obese men. We assessed the ... Full text Cite

The association between sexual function and prostate cancer risk in US veterans.

Journal Article Asian journal of andrology · March 2017 Sexual dysfunction and prostate cancer are common among older men. Few studies explored the association between these two illnesses. We examined whether sexual function is associated with prostate cancer risk among older men. Among 448 men undergoing prost ... Full text Cite

Obesity and prostate cancer-specific mortality after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) database.

Journal Article Prostate cancer and prostatic diseases · March 2017 BackgroundAt the population level, obesity is associated with prostate cancer (PC) mortality. However, few studies analyzed the associations between obesity and long-term PC-specific outcomes after initial treatment.MethodsWe conducted a ... Full text Cite

Number of Unfavorable Intermediate-Risk Factors Predicts Pathologic Upstaging and Prostate Cancer-Specific Mortality Following Radical Prostatectomy: Results From the SEARCH Database.

Journal Article The Prostate · February 2017 BackgroundTo validate and further improve the stratification of intermediate risk prostate cancer into favorable and unfavorable subgroups for patients undergoing radical prostatectomy.Materials and methodsThe SEARCH database was queried ... Full text Cite

Predicting Time From Metastasis to Overall Survival in Castration-Resistant Prostate Cancer: Results From SEARCH.

Journal Article Clin Genitourin Cancer · February 2017 OBJECTIVE: To identify the predictors of time from initial diagnosis of metastatic castration-resistance prostate cancer (mCRPC) to all-cause death within the Shared Equal Access Regional Cancer Hospital cohort. PATIENTS AND METHODS: We performed a retrosp ... Full text Link to item Cite

Serum cholesterol and risk of lower urinary tract symptoms progression: Results from the Reduction by Dutasteride of Prostate Cancer Events study.

Journal Article International journal of urology : official journal of the Japanese Urological Association · February 2017 ObjectiveTo determine if cholesterol is a risk factor for the development of lower urinary tract symptoms in asymptomatic men.MethodsA post-hoc analysis of the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study was carried ... Full text Cite

Do skeletal-related events predict overall survival in men with metastatic castration-resistant prostate cancer?

Journal Article Prostate cancer and prostatic diseases · December 2016 BackgroundSkeletal-related events (SREs) including pathologic fracture, spinal cord compression, radiation to bone and surgery to bone, are common in men with bone metastatic castration-resistant prostate cancer (mCRPC). Men with mCRPC are at high ... Full text Cite

Race does not predict the development of metastases in men with nonmetastatic castration-resistant prostate cancer.

Journal Article Cancer · December 2016 BackgroundAlthough race is associated with prostate cancer progression in early stage disease, once men have advanced disease, it is unclear whether race continues to predict a poor outcome. The authors hypothesized that, in an equal-access settin ... Full text Cite

Validation of a bone scan positivity risk table in non-metastatic castration-resistant prostate cancer.

Journal Article BJU international · October 2016 ObjectivesTo test the external validity of a previously developed risk table, designed to predict the probability of a positive bone scan among men with non-metastatic (M0) castration-resistant prostate cancer (CRPC), in a separate cohort.Pati ... Full text Cite

Utilization of a Genomic Classifier for Prediction of Metastasis Following Salvage Radiation Therapy after Radical Prostatectomy.

Journal Article European urology · October 2016 BackgroundDespite salvage radiation therapy (SRT) for recurrent prostate cancer (PCa) after radical prostatectomy (RP), some patients still progress to metastases. Identifying these men would allow them to undergo systemic therapy including testin ... Full text Cite

Predictors of Time to Metastasis in Castration-resistant Prostate Cancer.

Journal Article Urology · October 2016 OBJECTIVE: To investigate predictors of time to metastasis among men treated with androgen deprivation therapy for nonmetastatic prostate cancer who developed castration-resistant prostate cancer (CRPC) within the Shared Equal Access Regional Cancer Hospit ... Full text Link to item Cite

The Association between Phosphodiesterase Type 5 Inhibitors and Prostate Cancer: Results from the REDUCE Study.

Journal Article The Journal of urology · September 2016 PurposeDespite routine use of phosphodiesterase type 5 inhibitor to treat erectile dysfunction the role in prostate cancer chemoprevention remains unclear. Only a few studies have explored the link between phosphodiesterase type 5 inhibitor use an ... Full text Cite

Do all men with pathological Gleason score 8-10 prostate cancer have poor outcomes? Results from the SEARCH database.

Journal Article BJU international · August 2016 ObjectiveTo determine whether there are subsets of men with pathological high grade prostate cancer (Gleason score 8-10) with particularly high or low 2-year biochemical recurrence (BCR) risk after radical prostatectomy (RP) when stratified into g ... Full text Cite

Effect of positive end-expiratory pressure on blood loss during retropubic and robot-assisted laparoscopic radical prostatectomy.

Journal Article Int J Urol · August 2016 OBJECTIVES: To study the effect of end-expiratory pressure used during anesthesia on blood loss during radical prostatectomy. METHODS: We evaluated 247 patients who underwent either radical retropubic prostatectomy or robot-assisted laparoscopic prostatect ... Full text Link to item Cite

Racial differences in prostate inflammation: results from the REDUCE study.

Journal Article Oncotarget · July 18, 2016 Prostate cancer (PC) risk differs between races, and we previously showed prostate inflammation in benign prostate tissue was linked with a lower future PC risk. However, whether prostate tissue inflammation varies by race is unknown. We analyzed baseline ... Full text Cite

Adverse pathology and undetectable ultrasensitive prostate-specific antigen after radical prostatectomy: is adjuvant radiation warranted?

Journal Article BJU international · June 2016 ObjectivesTo determine if men with adverse pathology but undetectable ultrasensitive (<0.01 ng/mL) PSA are at high-risk for biochemical recurrence (BCR), or if there is a subset of patients at low-risk for whom the benefit of adjuvant radiation th ... Full text Cite

Baseline subject characteristics predictive of compliance with study-mandated prostate biopsy in men at risk of prostate cancer: results from REDUCE.

Journal Article Prostate cancer and prostatic diseases · June 2016 BackgroundStudy compliance is crucial when the study outcome is determined by an invasive procedure, such as prostate biopsy. To investigate predictors of compliance in study-mandated prostate biopsies, we analyzed demographic, clinical and report ... Full text Cite

Does Prostate Size Predict the Development of Incident Lower Urinary Tract Symptoms in Men with Mild to No Current Symptoms? Results from the REDUCE Trial.

Journal Article European urology · May 2016 BackgroundIt has been shown that increased prostate size is a risk factor for lower urinary tract symptom (LUTS) progression in men who currently have LUTS presumed due to benign prostatic hyperplasia (BPH).ObjectiveTo determine if prosta ... Full text Cite

Utilization and impact of surgical technique on the performance of pelvic lymph node dissection at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database.

Journal Article International journal of urology : official journal of the Japanese Urological Association · March 2016 ObjectiveTo evaluate performance of pelvic lymph node dissection during radical prostatectomy within an equal access care setting over a period of time, and stratified by prostate cancer risk group and surgical technique.MethodsWe identif ... Full text Cite

Racial Differences in the Association Between Preoperative Serum Cholesterol and Prostate Cancer Recurrence: Results from the SEARCH Database.

Journal Article Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · March 2016 BackgroundBlack men are disproportionately affected by both cardiovascular disease and prostate cancer. Epidemiologic evidence linking dyslipidemia, an established cardiovascular risk factor, and prostate cancer progression is mixed. As existing s ... Full text Cite

Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort.

Journal Article BJU international · February 2016 ObjectiveTo assess the impact of positive surgical margins (PSMs) on long-term outcomes after radical prostatectomy (RP), including metastasis, castrate-resistant prostate cancer (CRPC), and prostate cancer-specific mortality (PCSM).Patients a ... Full text Cite

Is computed tomography a necessary part of a metastatic evaluation for castration-resistant prostate cancer? Results from the Shared Equal Access Regional Cancer Hospital Database.

Journal Article Cancer · January 2016 BackgroundMetastatic lesions in prostate cancer beyond the bone have prognostic importance and affect clinical therapeutic decisions. Few data exist regarding the prevalence of soft-tissue metastases at the initial diagnosis of metastatic castrati ... Full text Cite

Does larger tumor volume explain the higher prostate specific antigen levels in black men with prostate cancer--Results from the SEARCH database.

Journal Article Cancer epidemiology · December 2015 ObjectivesTo assess whether larger tumor volume in black men explains higher presurgical PSA levels versus white men with prostate cancer.MethodsWe retrospectively analyzed 1904 men from the Shared Equal Access Regional Cancer Hospital da ... Full text Cite

Is PSA related to serum cholesterol and does the relationship differ between black and white men?

Journal Article Prostate · December 2015 BACKGROUND: Previously, in prostate cancer-free men, we found that statin initiation resulted in a 4.1% decline in PSA. This decline in PSA was proportional to the decline in cholesterol, suggesting a link between cholesterol and PSA levels. Whether these ... Full text Link to item Cite

Predicting bone scan positivity in non-metastatic castration-resistant prostate cancer.

Journal Article Prostate Cancer Prostatic Dis · December 2015 BACKGROUND: To evaluate PSA levels and kinetic cutoffs to predict positive bone scans for men with non-metastatic castration-resistant prostate cancer (CRPC) from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. METHODS: Retrospective anal ... Full text Link to item Cite

Metformin use and risk of prostate cancer: results from the REDUCE study.

Journal Article Cancer prevention research (Philadelphia, Pa.) · November 2015 The role of metformin in prostate cancer chemoprevention remains unclear. REDUCE, which followed biopsy-negative men with protocol-dictated PSA-independent biopsies at 2- and 4-years, provides an opportunity to evaluate the link between metformin use and p ... Full text Cite

Smoking is a predictor of adverse pathological features at radical prostatectomy: Results from the Shared Equal Access Regional Cancer Hospital database.

Journal Article International journal of urology : official journal of the Japanese Urological Association · July 2015 ObjectiveTo test the relationship of smoking and aggressive prostate cancer in men undergoing radical prostatectomy.MethodsA retrospective analysis of 2290 men who underwent radical prostatectomy from the Shared Equal Access Regional Canc ... Full text Cite

Does Obesity Modify the Ability of Prebiopsy Prostate Specific Antigen to Detect Prostate Cancer on Repeat Biopsy? Results from the REDUCE Study.

Journal Article The Journal of urology · July 2015 PurposeHigher body mass index is linked to lower prostate specific antigen. This has given rise to concerns that prostate specific antigen may be less reliable for predicting prostate cancer among obese men. We tested the accuracy of prebiopsy pro ... Full text Cite

Metabolic syndrome-like components and prostate cancer risk: results from the Reduction by Dutasteride of Prostate Cancer Events (REDUCE) study.

Journal Article BJU international · May 2015 ObjectiveTo evaluate the relationship between number of metabolic syndrome (MetS)-like components and prostate cancer diagnosis in a group of men where nearly all biopsies were taken independent of prostate-specific antigen (PSA) level, thus minim ... Full text Cite

The association of exercise with both erectile and sexual function in black and white men.

Journal Article The journal of sexual medicine · May 2015 IntroductionThere is growing interest in using exercise to treat. Although many studies have highlighted the relationship between better erectile function and exercise, black men have been underrepresented in the literature.AimsThis study ... Full text Cite

Practice patterns and predictors of followup imaging after a negative bone scan in men with castration resistant prostate cancer: results from the SEARCH database.

Journal Article J Urol · April 2015 PURPOSE: We investigated imaging practice patterns in men with nonmetastatic (M0) castration resistant prostate cancer. MATERIALS AND METHODS: We analyzed data on 247 patients with documented M0 CRPC from the SEARCH database. Patients were selected regardl ... Full text Link to item Cite

Prostate-specific antigen level, stage or Gleason score: which is best for predicting outcomes after radical prostatectomy, and does it vary by the outcome being measured? Results from Shared Equal Access Regional Cancer Hospital database.

Journal Article International journal of urology : official journal of the Japanese Urological Association · April 2015 ObjectivesTo assess the ability of preoperative prostate-specific antigen level, Gleason score and stage to predict prostate cancer outcomes beyond biochemical recurrence, specifically castration-resistant prostate cancer, metastases and prostate ... Full text Cite

Carbohydrate intake, glycemic index and prostate cancer risk.

Journal Article Prostate · March 1, 2015 BACKGROUND: Reported associations between dietary carbohydrate and prostate cancer (PC) risk are poorly characterized by race. METHODS: We analyzed the association between carbohydrate intake, glycemic index (GI), and PC risk in a study of white (N = 262) ... Full text Link to item Cite

Aspirin, NSAIDs, and risk of prostate cancer: results from the REDUCE study.

Journal Article Clinical cancer research : an official journal of the American Association for Cancer Research · February 2015 PurposeA recent meta-analysis showed that aspirin was associated with reduced prostate cancer risk. As anti-inflammatory medications lower PSA levels, whether these findings reflect reduced prostate cancer detection or lower prostate cancer risk i ... Full text Cite

Alcohol intake increases high-grade prostate cancer risk among men taking dutasteride in the REDUCE trial.

Journal Article European urology · December 2014 BackgroundAlthough most studies found no association between alcohol intake and prostate cancer (PCa) risk, an analysis of the Prostate Cancer Prevention Trial found that high alcohol intake significantly increased PCa risk among men randomized to ... Full text Cite

Obesity increases the risk for high-grade prostate cancer: results from the REDUCE study.

Journal Article Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · December 2014 BackgroundStudies suggest that obesity is associated with lower risk of prostate cancer but more aggressive cancers. As obesity lowers PSA levels, these observations may be influenced by detection bias. We examined the association between obesity ... Full text Cite

Racial differences in adipose tissue distribution and risk of aggressive prostate cancer among men undergoing radiotherapy.

Journal Article Cancer Epidemiol Biomarkers Prev · November 2014 BACKGROUND: Although elevated body mass index (BMI) has been associated with increased risk of aggressive prostate cancer, the importance of adipose tissue distribution is not well understood. We examined associations between overall and visceral obesity a ... Full text Link to item Cite

Serum lipid profile and risk of prostate cancer recurrence: Results from the SEARCH database.

Journal Article Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · November 2014 BackgroundEvidence for an association between total cholesterol, low- and high-density lipoproteins (LDL and HDL, respectively), triglycerides, and prostate cancer is conflicting. Given that prostate cancer and dyslipidemia affect large proportion ... Full text Cite

Smoking and risk of low- and high-grade prostate cancer: results from the REDUCE study.

Journal Article Clin Cancer Res · October 15, 2014 PURPOSE: Although the relationship between smoking and prostate cancer risk is inconsistent, some studies show that smoking is associated with prostate cancer mortality. Whether this reflects delayed diagnosis or direct smoking-related effects is unknown. ... Full text Link to item Cite

Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database.

Journal Article Prostate Cancer Prostatic Dis · March 2014 BACKGROUND: To evaluate the factors associated with positive bone scans after biochemical recurrence (BCR) following radical prostatectomy in both hormone-naive subjects and subjects after androgen-deprivation therapy (ADT). METHODS: Retrospective analysis ... Full text Link to item Cite

Postoperative statin use and risk of biochemical recurrence following radical prostatectomy: Results from the SEARCH database

Journal Article BJU Int · March 1, 2014 Objective To investigate the effect of postoperative statin use on biochemical recurrence (BCR) in PC patients treated with radical prostatectomy (RP) who never used statins before surgery. Patients and Methods We conducted a retrospective analysis of 1,14 ... Full text Open Access Link to item Cite