Crystallization of the purine salvage enzyme adenine phosphoribosyltransferase.

Journal Article (Journal Article)

Adenine phosphoribosyltransferase from the protozoan parasite Leishmania donovani has been crystallized in the presence of the substrate Mg(2+)-alpha-D-5-phosphoribosyl-1-pyrophosphate (PRPP) or the product adenosine-5-monophosphate, as well as in the absence of ligand. These crystals belong to the space group P6(1)22 or its enantiomorph P6(5)22, with unit cell dimensions of a = b = 64.0 A, c = 240.5 A, alpha = beta = 90 degrees, and gamma = 120 degrees. The crystals diffract to 1.9 A.

Full Text

Duke Authors

Cited Authors

  • Phillíps, CL; Ullman, B; Brennan, RG

Published Date

  • August 1996

Published In

Volume / Issue

  • 25 / 4

Start / End Page

  • 510 - 513

PubMed ID

  • 8865346

International Standard Serial Number (ISSN)

  • 0887-3585

Digital Object Identifier (DOI)

  • 10.1002/prot.11

Language

  • eng

Conference Location

  • United States