Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways.
Journal Article mBio · October 8, 2025 Infections caused by fungal pathogens such as Candida and Cryptococcus are associated with high mortality rates, partly due to limitations in the current antifungal arsenal. This highlights the need for antifungal drug targets with novel mechanisms of acti ... Full text Link to item CiteInhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways.
Preprint · June 18, 2025 Full text Link to item CiteA single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression.
Journal Article Cell Rep · April 22, 2025 Salmonella causes ∼1 million cases of gastroenteritis annually in the United States. Critical to virulence are secreted effectors that reprogram host functions. We previously discovered the effector SarA facilitates phosphorylation of STAT3, inducing expre ... Full text Link to item CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029The Molecular Mechanism and Pathophysiology of Robust STAT3 Signaling During Oral Salmonella Typhimurium Infection
FellowshipCo-Sponsor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchCo-Principal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026View All Grants
Education, Training & Certifications
University of Wisconsin, Madison ·
1984
Ph.D.