Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Recent Publications
Inhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways
Preprint · March 10, 2025 Full text CiteStructures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: A target for antifungals.
Journal Article Proc Natl Acad Sci U S A · August 6, 2024 Invasive fungal diseases are a major threat to human health, resulting in more than 1.5 million annual deaths worldwide. The arsenal of antifungal therapeutics remains limited and is in dire need of drugs that target additional biosynthetic pathways that a ... Full text Link to item CiteHow c-di-GMP controls progression through the Streptomyces life cycle.
Journal Article Curr Opin Microbiol · August 2024 Members of the antibiotic-producing bacterial genus Streptomyces undergo a complex developmental life cycle that culminates in the production of spores. Central to control of this cell differentiation process is signaling through the second messenger 3', 5 ... Full text Link to item CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029The Molecular Mechanism and Pathophysiology of Robust STAT3 Signaling During Oral Salmonella Typhimurium Infection
FellowshipCo-Sponsor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2026View All Grants
Education, Training & Certifications
University of Wisconsin, Madison ·
1984
Ph.D.