https://orcid.org/0000-0001-7647-485X
Current Duke Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Recent Scholarly Works
Mitochondrial cardiolipin sequestration of caspofungin underlies Cryptococcus neoformans inherent resistance and may contribute to cardiotoxicity.
Preprint · January 20, 2026 Cryptococcus exhibits inherent resistance to the echinocandin, caspofungin, which inhibits the synthesis of (1,3)-β-D-glucan, a key component of the polysaccharide cell wall. The essential FKS1 gene encodes the catalytic subunit of (1,3)-β-D-glucan synthas ... Full text Link to item CiteInhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways.
Journal article mBio · October 8, 2025 Infections caused by fungal pathogens such as Candida and Cryptococcus are associated with high mortality rates, partly due to limitations in the current antifungal arsenal. This highlights the need for antifungal drug targets with novel mechanisms of acti ... Full text Link to item CiteInhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways.
Preprint · June 18, 2025 UNLABELLED: Infections caused by fungal pathogens such as Candida and Cryptococcus are associated with high mortality rates, partly due to limitations in the current antifungal arsenal. This highlights the need for antifungal drug targets with novel mechan ... Full text Link to item CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2029Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchCo-Principal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2027The Molecular Mechanism and Pathophysiology of Robust STAT3 Signaling During Oral Salmonella Typhimurium Infection
FellowshipCo-Sponsor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027View All Grants
Education
University of Wisconsin, Madison ·
1984
Ph.D.