Current Appointments & Affiliations
James B. Duke Distinguished Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Professor of Biochemistry
·
2011 - Present
Biochemistry,
Basic Science Departments
Recent Publications
A single amino acid in the Salmonella effector SarA/SteE triggers supraphysiological activation of STAT3 for anti-inflammatory gene expression.
Journal Article Cell Rep · April 22, 2025 Salmonella causes ∼1 million cases of gastroenteritis annually in the United States. Critical to virulence are secreted effectors that reprogram host functions. We previously discovered the effector SarA facilitates phosphorylation of STAT3, inducing expre ... Full text Link to item CiteInhibitors of trehalose-6-phosphate synthase activity in fungal pathogens compromise thermal tolerance pathways.
Preprint · March 7, 2025 Full text Link to item CiteStructures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans: A target for antifungals.
Journal Article Proc Natl Acad Sci U S A · August 6, 2024 Invasive fungal diseases are a major threat to human health, resulting in more than 1.5 million annual deaths worldwide. The arsenal of antifungal therapeutics remains limited and is in dire need of drugs that target additional biosynthetic pathways that a ... Full text Link to item CiteRecent Grants
Tri-Institutional Molecular Mycology and Pathogenesis Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2024 - 2029The Molecular Mechanism and Pathophysiology of Robust STAT3 Signaling During Oral Salmonella Typhimurium Infection
FellowshipCo-Sponsor · Awarded by National Institute of Allergy and Infectious Diseases · 2024 - 2027Molecular elucidation of the Francisella tularensis virulence mechanism
ResearchCo-Principal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2021 - 2026View All Grants
Education, Training & Certifications
University of Wisconsin, Madison ·
1984
Ph.D.