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Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents.

Publication ,  Journal Article
Judd, RM; Reeder, SB; May-Newman, K
Published in: Magn Reson Med
February 1999

To investigate the effects of water exchange on quantification of perfusion, data were acquired in isolated hearts (n = 11) and used to develop a model of exchange. Myocardial T1 was measured 3 times/sec during step changes in concentration of intravascular (polylysine-gadolinium-diethylene-triamine-pentaacetic acid) and extracellular (gadoteridol) agents. For the intravascular agent, the change in 1/T1 (deltaR1) was lower than predicted by fast exchange (2.7+/-0.5 vs. 7.8 sec(-1), respectively), and suggested an intra-extravascular exchange rate of 3 Hz. For the extracellular agent, contrast kinetics were similar to those of similarly sized molecules (wash-in time constant 38+/-5 sec), and the data suggested fast interstitial-cellular exchange. Modeling showed that perfusion is underestimated for both agents if exchange is ignored, although the relationships of measured to actual perfusion were monotonic. We conclude that myocardial water exchange strongly affects first-pass enhancement but that ignoring the effects of exchange may still provide reasonable estimates of regional perfusion differences.

Duke Scholars

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

February 1999

Volume

41

Issue

2

Start / End Page

334 / 342

Location

United States

Related Subject Headings

  • Rabbits
  • Polylysine
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Magnetic Resonance Imaging
  • In Vitro Techniques
  • Heterocyclic Compounds
  • Gadolinium DTPA
  • Gadolinium
 

Citation

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MLA
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Judd, R. M., Reeder, S. B., & May-Newman, K. (1999). Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents. Magn Reson Med, 41(2), 334–342. https://doi.org/10.1002/(sici)1522-2594(199902)41:2<334::aid-mrm18>3.0.co;2-y
Judd, R. M., S. B. Reeder, and K. May-Newman. “Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents.Magn Reson Med 41, no. 2 (February 1999): 334–42. https://doi.org/10.1002/(sici)1522-2594(199902)41:2<334::aid-mrm18>3.0.co;2-y.
Judd RM, Reeder SB, May-Newman K. Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents. Magn Reson Med. 1999 Feb;41(2):334–42.
Judd, R. M., et al. “Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents.Magn Reson Med, vol. 41, no. 2, Feb. 1999, pp. 334–42. Pubmed, doi:10.1002/(sici)1522-2594(199902)41:2<334::aid-mrm18>3.0.co;2-y.
Judd RM, Reeder SB, May-Newman K. Effects of water exchange on the measurement of myocardial perfusion using paramagnetic contrast agents. Magn Reson Med. 1999 Feb;41(2):334–342.
Journal cover image

Published In

Magn Reson Med

DOI

ISSN

0740-3194

Publication Date

February 1999

Volume

41

Issue

2

Start / End Page

334 / 342

Location

United States

Related Subject Headings

  • Rabbits
  • Polylysine
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Myocardium
  • Magnetic Resonance Imaging
  • In Vitro Techniques
  • Heterocyclic Compounds
  • Gadolinium DTPA
  • Gadolinium