Maternal vitamin A restriction alters biochemical development of the brain in rats.
Publication
, Journal Article
Sharma, HS; Misra, UK
Published in: Experientia
February 15, 1990
The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 micrograms retinol/day/kg body weight, respectively) of vitamin A during pregnancy and suckling. The maternal vitamin A restriction caused an altered brain development in terms of tissue weight, DNA, RNA and protein levels, and biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine, respectively. A dose-dependent effect of maternal vitamin A restriction on the metabolism of DNA, RNA and protein was noticed in the developing fetal brain of rats.
Duke Scholars
Published In
Experientia
DOI
ISSN
0014-4754
Publication Date
February 15, 1990
Volume
46
Issue
2
Start / End Page
208 / 211
Location
Switzerland
Related Subject Headings
- Vitamin A Deficiency
- Rats, Inbred Strains
- Rats
- RNA
- Proteins
- Pregnancy
- Organ Size
- Maternal-Fetal Exchange
- Female
- Embryonic and Fetal Development
Citation
APA
Chicago
ICMJE
MLA
NLM
Sharma, H. S., & Misra, U. K. (1990). Maternal vitamin A restriction alters biochemical development of the brain in rats. Experientia, 46(2), 208–211. https://doi.org/10.1007/BF02027317
Sharma, H. S., and U. K. Misra. “Maternal vitamin A restriction alters biochemical development of the brain in rats.” Experientia 46, no. 2 (February 15, 1990): 208–11. https://doi.org/10.1007/BF02027317.
Sharma HS, Misra UK. Maternal vitamin A restriction alters biochemical development of the brain in rats. Experientia. 1990 Feb 15;46(2):208–11.
Sharma, H. S., and U. K. Misra. “Maternal vitamin A restriction alters biochemical development of the brain in rats.” Experientia, vol. 46, no. 2, Feb. 1990, pp. 208–11. Pubmed, doi:10.1007/BF02027317.
Sharma HS, Misra UK. Maternal vitamin A restriction alters biochemical development of the brain in rats. Experientia. 1990 Feb 15;46(2):208–211.
Published In
Experientia
DOI
ISSN
0014-4754
Publication Date
February 15, 1990
Volume
46
Issue
2
Start / End Page
208 / 211
Location
Switzerland
Related Subject Headings
- Vitamin A Deficiency
- Rats, Inbred Strains
- Rats
- RNA
- Proteins
- Pregnancy
- Organ Size
- Maternal-Fetal Exchange
- Female
- Embryonic and Fetal Development