Maternal vitamin A restriction alters biochemical development of the brain in rats.

Journal Article (Journal Article)

The biochemical development of the fetal brain in relation to maternal vitamin A restriction was studied in rats. The vitamin A status of pregnant rats was varied by supplying low, medium and adequate amounts (6, 40, and 100 micrograms retinol/day/kg body weight, respectively) of vitamin A during pregnancy and suckling. The maternal vitamin A restriction caused an altered brain development in terms of tissue weight, DNA, RNA and protein levels, and biosynthesis of DNA and protein from [3H]-thymidine and [3H]-leucine, respectively. A dose-dependent effect of maternal vitamin A restriction on the metabolism of DNA, RNA and protein was noticed in the developing fetal brain of rats.

Full Text

Duke Authors

Cited Authors

  • Sharma, HS; Misra, UK

Published Date

  • February 15, 1990

Published In

Volume / Issue

  • 46 / 2

Start / End Page

  • 208 - 211

PubMed ID

  • 1689258

International Standard Serial Number (ISSN)

  • 0014-4754

Digital Object Identifier (DOI)

  • 10.1007/BF02027317


  • eng

Conference Location

  • Switzerland