Uma Kant Misra
Professor Emeritus of Pathology

1. Biology of α2 MSR: Ligands binding and their regulation, receptor upregulation, defining signaling cascades components, modulation of ser/thr/tyr kinase activities, cellular responses (mitogenesis, gene expression), physiological relevance.

2. Receptor activation, and membrane phospholipases - PLA2, PI-PLCb, PI-PLCg, PC-PLC, PLD, sphingomyelinase, and ceramide signaling, regulation, role in mitogenesis.

3. α2 MSR and malignancy - Prostate cancer cell line e.g. 1LN, PC3, LnCap as model. Modulation of cellular responses by inhibitors of down stream signaling cascades, a2MSR and p53 (tumor suppressor gene) expression.

4. Cations, α2 MSR and genotoxicity - bivalen and trivalen cations and binding of α2 M* to α2 MSR, signaling cascades compnents and their regulation, mitogenesis.

5. Isolation, purification and characterization of α - Autophosphorylation of the receptor on ligands binding, amino acid residues involved in receptor activation, mechanism of receptor desensitization, modulators/coactivators binding domains on the receptor, differences between LRP/α2 MR and α2 MSR, transfection studies.

6. α2 MSR and neuronal development -

7. Internalization and proteosomies targeting of alpha-2-macroglobulin signaling receptor- A possible metabolic advantage for the isolation of α2 MSR during its proteosome targeting.

8. Cadmium and development of prostate malignancy-use of human prostate cancer cell liens as model. Delineating the role of farnesyl transferase, p21-Ras activation, MAPK and PI 3-kinase signaling cascades, transcription fractors and early response genes in malignancy development.

Current Appointments & Affiliations

Contact Information

  • 308 Davison Bldg, Durham, NC 27710
  • Duke Box 3712, Durham, NC 27710

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