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Uma Kant Misra

Professor Emeritus of Pathology
Duke Box 3712, Durham, NC 27710
308 Davison Bldg, Durham, NC 27710


1. Biology of α2MSR: Ligands binding and their regulation, receptor upregulation, defining signaling cascades components, modulation of ser/thr/tyr kinase activities, cellular responses (mitogenesis, gene expression), physiological relevance.

2. Receptor activation, and membrane phospholipases - PLA2, PI-PLCb, PI-PLCg, PC-PLC, PLD, sphingomyelinase, and ceramide signaling, regulation, role in mitogenesis.

3. α2MSR and malignancy - Prostate cancer cell line e.g. 1LN, PC3, LnCap as model. Modulation of cellular responses by inhibitors of down stream signaling cascades, a2MSR and p53 (tumor suppressor gene) expression.

4. Cations, α2MSR and genotoxicity - bivalen and trivalen cations and binding of α2M* to α2MSR, signaling cascades components and their regulation, mitogenesis.

5. Isolation, purification and characterization of α - Autophosphorylation of the receptor on ligands binding, amino acid residues involved in receptor activation, mechanism of receptor desensitization, modulators/coactivators binding domains on the receptor, differences between LRP/α2MR and α2MSR, transfection studies.

6. α2MSR and neuronal development -

7. Internalization and proteosomies targeting of alpha-2-macroglobulin signaling receptor- A possible metabolic advantage for the isolation of α2MSR during its proteosome targeting.

8. Cadmium and development of prostate malignancy-use of human prostate cancer cell liens as model. Delineating the role of farnesyl transferase, p21-Ras activation, MAPK and PI 3-kinase signaling cascades, transcription factors and early response genes in malignancy development.

Current Appointments & Affiliations

Professor Emeritus of Pathology · 2014 - Present Pathology, Clinical Science Departments

Education, Training & Certifications

Kansas State University · 1959 Ph.D.